Delfina Costa
University of Genoa
Internal medicineDownregulation and upregulationEndocrinologyPathologyCellular differentiationCellCytotoxic T cellChemistryNon-coding RNAIn vitroImmunologyIn vivoNeuroblastomaImmunotherapyCancer researchEffectorColorectal cancerGeneticsCell growthMedicineBiologyImmune systemCell biology
28Publications
11H-index
333Citations
Publications 28
Newest
Lung fibrosis has specific computed tomography (CT) findings and represents a common finding in advanced COVID-19 pneumonia whose reversibility has been poorly investigated. The aim of this study was to quantify the extension of collagen deposition and aeration in postmortem cryobiopsies of critically ill COVID-19 patients and to describe the correlations with qualitative and quantitative analyses of lung CT. Postmortem transbronchial cryobiopsy samples were obtained, formalin fixed, paraffin em...
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#1Alessandro PoggiH-Index: 56
#2Federico VillaH-Index: 5
Last. Roberto BenelliH-Index: 55
view all 6 authors...
Several approaches have shown that the immune response against tumors strongly affects patients’ clinical outcome. Thus, the study of anti-tumor immunity is critical to understand and potentiate the mechanisms underlying the elimination of tumor cells. Natural killer (NK) cells are members of innate immunity and represent powerful anti-tumor effectors, able to eliminate tumor cells without a previous sensitization. Thus, the study of their involvement in anti-tumor responses is critical for clin...
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#1Roberta Pece (UniGe: University of Genoa)H-Index: 2
#2Sara Tavella (UniGe: University of Genoa)H-Index: 17
Last. Cristina D'ArrigoH-Index: 19
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Shedding of A Disintegrin And Metalloproteinases (ADAM10) substrates, like TNFα or CD30, can affect both anti-tumor immune response and antibody-drug-conjugate (ADC)-based immunotherapy. We have published two new ADAM10 inhibitors, LT4 and MN8 able to prevent such shedding in Hodgkin lymphoma (HL). Since tumor tissue architecture deeply influence the outcome of anti-cancer treatments, we set up new three-dimensional (3D) culture systemsto verify whether ADAM10 inhibitors can contribute to, or en...
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#1Azzurra SargentiH-Index: 2
#2Francesco MusmeciH-Index: 2
Last. Alessandro PoggiH-Index: 56
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To improve pathogenetic studies in cancer development and reliable preclinical testing of anti-cancer treatments, three-dimensional (3D) cultures, including spheroids, have been widely recognized as more physiologically relevant in vitro models of in vivo tumor behavior. Currently, the generation of uniformly sized spheroids is still challenging: different 3D cell culture methods produce heterogeneous populations in dimensions and morphology, that may strongly influence readouts reliability corr...
3 CitationsSource
#1Patrizia GarbatiH-Index: 7
#2R BarbieriH-Index: 10
Last. Aldo PaganoH-Index: 25
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To overcome the lack of effective pharmacological treatments for high-risk neuroblastoma (HR-NB), the development of novel in vitro and in vivo models that better recapitulate the disease is required. Here, we used an in vitro multiclonal cell model encompassing NB cell differentiation stages, to identify potential novel pharmacological targets. This model allowed us to identify, by low-density RT-PCR arrays, two gene sets, one over-expressed during NB cell differentiation, and the other up-regu...
2 CitationsSource
#1Paola BarboroH-Index: 19
#2Roberto BenelliH-Index: 55
Last. Nicoletta FerrariH-Index: 30
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Castration-resistant prostate cancer (CRPC) is an incurable stage of the disease. A multivariate principal component analysis on CRPC in vitro models identified aspartyl (asparaginyl) β hydrolase (ASPH) as the most relevant molecule associated with the CRPC phenotype. ASPH is overexpressed in various malignant neoplasms and catalyzes the hydroxylation of aspartyl and asparaginyl residues in the epidermal growth factor (EGF)-like domains of proteins like NOTCH receptors and ligands, enhancing cel...
4 CitationsSource
#1Roberto BenelliH-Index: 55
#2Delfina CostaH-Index: 11
Last. Nicoletta FerrariH-Index: 30
view all 8 authors...
2 CitationsSource
#1Roberto BenelliH-Index: 55
#2Delfina CostaH-Index: 11
Last. Nicoletta FerrariH-Index: 30
view all 8 authors...
Colorectal cancer’s (CRC) ability to invade local tissues and lymph nodes and generate distant metastases is the key for TNM classification. Aspartate-β-hydroxylase (ASPH), a transmembrane protein that catalyzes Notch receptors and ligand activation, is involved in tumor invasion. Because Notch is involved in gut homeostasis, it could be a target for CRC therapy. ASPH mRNA and protein expression, promoter methylation and gene copy numbers were evaluated using the TCGA and CPTAC human CRC dataset...
5 CitationsSource
#1Roberta VenèH-Index: 22
#2Delfina CostaH-Index: 11
Last. Roberto BenelliH-Index: 55
view all 18 authors...
Observational/retrospective studies indicate that prostaglandin-endoperoxide synthase-2 (PTGS2) inhibitors could positively affect colorectal cancer (CRC) patients’ survival after diagnosis. To obtain an acceptable cost/benefit balance, the inclusion of PTGS2 inhibitors in the adjuvant setting needs a selective criterion. We quantified the 72 kDa, CRC-associated, glycosylated form of PTGS2 in 100 frozen CRC specimens and evaluated PTGS2 localization by IHC in the same tumors, scoring tumor epith...
2 CitationsSource
Background: Prostate cancer (PCa) is a significant health concern throughout the world. Standard therapy for advanced disease consists of anti-androgens, however, almost all prostate tumors become castration resistant (CRPC). Progression from androgen-sensitive PCa to CRPC is promoted by inflammatory signaling through cyclooxygenase-2 (COX-2) expression and ErbB family receptors/AKT activation, compensating androgen receptor inactivity. Methods: Making use of CRPC cell lines, we investigated the...
4 CitationsSource