Martin A. Ebert
University of Western Australia
Imaging phantomQuality assuranceOpticsPhysicsInternal medicineRadiologyOncologyLinear particle acceleratorMedical physicsRadiation treatment planningExternal beam radiotherapyProstateBrachytherapyProstate cancerNuclear medicineComputer scienceRadiation therapyClinical trialMedicineDosimetry
237Publications
26H-index
1,814Citations
Publications 239
Newest
#1Nathaniel Barry (UWA: University of Western Australia)
#2Pejman Rowshanfarzad (UWA: University of Western Australia)H-Index: 16
Last. Martin A. Ebert (UWA: University of Western Australia)H-Index: 26
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Positron emission tomography (PET) imaging using the amino acid tracer O-[2-(18F)fluoroethyl]-L-tyrosine (FET) has gained increased popularity within the past decade in the management of glioblastoma (GBM). Radiomics features extracted from FET PET images may be sensitive to variations when imaging at multiple time points. It is therefore necessary to assess feature robustness to test-retest imaging. Eight patients with histologically confirmed GBM that had undergone post-surgical test-retest FE...
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#1Yutong Zhao (UWA: University of Western Australia)
#2Martin A. Ebert (UWA: University of Western Australia)H-Index: 26
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Planning organ-at-risk volume (PRV) margins can be applied to the bladder and rectum in prostate external beam radiation therapy (EBRT), in order to incorporate the uncertainties resulting from their inter-fraction motion. For each of a total of 16 patients, the bladder and rectum were delineated on CBCT images for five treatment fractions in addition to the planning CT image set. The bladder and rectum boundary displacements across the images were measured and the frequency and size of organ bo...
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#1M. P. Barnes (University of Newcastle)H-Index: 10
#2D.J. O'Connor (University of Newcastle)H-Index: 26
Last. Martin A. EbertH-Index: 26
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A novel method of producing fluorine-18 for Positron emission tomography (PET) scan applications is evaluated theoretically. The method is based upon the 3He(d,p)4He nuclear reaction from which the protons produced are used to produce fluorine-18 via the 18O(p,n)18F reaction. The potential advantage of such a system over cyclotron-based production is of lower input beam energy, which may lower the cost of the system and potentially allow for onsite production. Two theoretical designs were invest...
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#1Simon Goodall (UWA: University of Western Australia)H-Index: 1
Last. Martin A. Ebert (UWA: University of Western Australia)H-Index: 26
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PURPOSE The use of 3D printing to develop custom phantoms for dosimetric studies in radiotherapy is increasing. The process allows production of phantoms designed to evaluated specific geometries, patients or patient groups with a defining feature. The ability to print bone equivalent phantoms has however proved challenging. The purpose of this work was to 3D print a series of three similar spine phantoms containing no surgical implants, implants made of titanium and implants made of carbon-fibr...
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#1Martin A. Ebert (SCGH: Sir Charles Gairdner Hospital)H-Index: 26
#2Sarah L. Gulliford (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 23
Last. Claudio Fiorino (UniSR: Vita-Salute San Raffaele University)H-Index: 54
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For decades, dose-volume information for segmented anatomy has provided the essential data for correlating radiotherapy dosimetry with treatment-induced complications. Dose-volume information has formed the basis for modelling those associations via normal tissue complication (NTCP) models and for driving treatment planning. Limitations to this approach have been identified. Many studies have emerged demonstrating that the incorporation of information describing the spatial nature of the dose di...
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#1Jessica Buck (Telethon Institute for Child Health Research)
#1Jessica Buck (UWA: University of Western Australia)
Last. Raelene Endersby (Telethon Institute for Child Health Research)H-Index: 11
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Medulloblastoma is the most common malignant childhood brain tumor, and five-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the induction of DNA damage, the sensitization of cancer cells through the inhibition of DNA damage repair pathways is a potential therapeutic strategy. The poly-(ADP-ribose) polymerase (PARP) inhibitor veliparib was assessed for its ability to augment the ce...
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#1P. Ferjancic (UW: University of Wisconsin-Madison)
#2Martin A. Ebert (SCGH: Sir Charles Gairdner Hospital)H-Index: 26
Last. Robert Jeraj (UW: University of Wisconsin-Madison)H-Index: 46
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PURPOSE O-(2-[18F]fluoroethyl)-L-tyrosine (FET), a PET radiotracer of amino acid uptake, has shown potential for diagnosis and treatment planning in patients with glioblastoma (GBM). To improve quantitative assessment of FET PET imaging, we evaluated the repeatability of uptake of this tracer in patients with GBM. METHODS Test-retest FET PET imaging was performed on 8 patients with histologically confirmed GBM, who previously underwent surgical resection of the tumour. Data were acquired accordi...
1 CitationsSource
#1Rebecca A. D’Alonzo (UWA: University of Western Australia)
#2Suki Gill (UWA: University of Western Australia)H-Index: 3
Last. Martin A. Ebert (UWA: University of Western Australia)H-Index: 26
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PURPOSE Tumors exhibit areas of decreased oxygenation due to malformed blood vessels. This low oxygen concentration decreases the effectiveness of radiation therapy, and the resulting poor perfusion can prevent drugs from reaching areas of the tumor. Tumor hypoxia is associated with poorer prognosis and disease progression and is therefore of interest to preclinical researchers. Although there are multiple different ways to measure tumor hypoxia and related factors, there is no standard for quan...
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#1Emily Jungmin Her (UWA: University of Western Australia)H-Index: 3
#2Martin A. Ebert (UWA: University of Western Australia)H-Index: 26
Last. Annette Haworth (USYD: University of Sydney)H-Index: 23
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Hypofractionation of prostate cancer radiotherapy achieves tumour control at lower total radiation doses, however, increased rectal and bladder toxicities have been observed. To realise the radiobiological advantage of hypofractionation whilst minimising harm, the potential reduction in dose to organs at risk was investigated for biofocused radiotherapy. Patient-specific tumour location and cell density information were derived from multiparametric imaging. Uniform-dose plans and biologically-op...
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#1Jessica Buck (UWA: University of Western Australia)
#1Jessica Buck (UWA: University of Western Australia)
Last. Raelene Endersby (UWA: University of Western Australia)H-Index: 11
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