Anna R. Docherty
University of Utah
GeneGenome-wide association studyPsychiatryPsychopathologyDevelopmental psychologyPsychologyHeritabilityCognitionCognitive psychologyGenetic associationGenomicsBipolar disorderDepression (differential diagnoses)Major depressive disorderPopulationGeneticsClinical psychologyMedicineSchizophreniaBiologyNeuroticism
Publications 117
#1Anna Alkelai (CUMC: Columbia University Medical Center)H-Index: 14
#2Lior Greenbaum (Sheba Medical Center)H-Index: 20
Last. David Goldstein (CUMC: Columbia University Medical Center)H-Index: 156
view all 22 authors...
Schizophrenia has a multifactorial etiology, involving a polygenic architecture. The potential benefit of whole genome sequencing (WGS) in schizophrenia and other psychotic disorders is not well studied. We investigated the yield of clinical WGS analysis in 251 families with a proband diagnosed with schizophrenia (N = 190), schizoaffective disorder (N = 49), or other conditions involving psychosis (N = 48). Participants were recruited in Israel and USA, mainly of Jewish, Arab, and other European...
#1Hilary CoonH-Index: 78
#2Elliott FerrisH-Index: 8
Last. Amanda V. BakianH-Index: 17
view all 15 authors...
#1Anna R. Docherty (UofU: University of Utah)H-Index: 23
#2Amanda V. Bakian (UofU: University of Utah)H-Index: 17
Last. Douglas GrayH-Index: 8
view all 11 authors...
Approximately 5% of individuals with schizophrenia die from suicide. However, suicide in psychosis is still poorly characterized, partly due to a lack of adequate population-based clinical or genetic data on suicide death. The Utah Suicide Genetics Research Study (USGRS) provides a large population-based cohort of suicide deaths with medical record and genome-wide data (N = 4380). Examination of this cohort identified medical and genetic risks associated with type of suicide death and investigat...
#1Monika A. WaszczukH-Index: 19
#2Jiaju MiaoH-Index: 2
Last. Roman KotovH-Index: 61
view all 7 authors...
#1Niamh Mullins (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 18
#2Jooeun Kang (VUMC: Vanderbilt University Medical Center)H-Index: 8
Last. Anna StarnawskaH-Index: 13
view all 266 authors...
Abstract null null Background null Suicide is a leading cause of death worldwide, and non-fatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. null null null Methods null We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the Internatio...
#1Anna R. Docherty (VCU: Virginia Commonwealth University)H-Index: 23
#2Brent M. KiousH-Index: 8
Last. Hilary Coon (UofU: University of Utah)H-Index: 78
view all 10 authors...
Genome-wide association studies (GWAS) provide valuable information in research contexts regarding genomic changes that contribute to risks for complex psychiatric conditions like major depressive disorder. GWAS results can be used to calculate polygenic risk scores (PRS) for psychiatric conditions, such as bipolar disorder or schizophrenia, as well as for other traits, such as obesity or hypertension. Private companies that provide direct-to-consumer (DTC) genetic testing sometimes report PRS f...
#1Amanda V. BakianH-Index: 17
#2Danli ChenH-Index: 4
view all 12 authors...
#1Eric T. Monson (UofU: University of Utah)H-Index: 9
#2Andrey A. Shabalin (UofU: University of Utah)H-Index: 26
Last. Niamh Mullins (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 18
view all 12 authors...
Bipolar disorder (BP) suicide death rates are 10-30 times greater than the general population, likely arising from environmental and genetic risk factors. Though suicidal behavior in BP has been investigated, studies have not addressed combined clinical and genetic factors specific to suicide death. To address this gap, a large, harmonized BP cohort was assessed to identify clinical risk factors for suicide death and attempt which then directed testing of underlying polygenic risks. 5901 individ...
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