Hak Sun Yu
Pusan National University
GeneImmunoglobulin EMolecular biologyRestriction fragment length polymorphismChemistryInterleukin 10ImmunologyInflammationCytokineAcanthamoebaFOXP3Trichinella spiralisAnisakis simplexGeneticsBiochemistryMedicineIL-2 receptorBiologyImmune systemMicrobiologyCell biology
170Publications
27H-index
2,190Citations
Publications 172
Newest
#1Mi Jin Jeong (PNU: Pusan National University)
#2Shin Ae Kang (PNU: Pusan National University)H-Index: 12
Last. Hak Sun Yu (PNU: Pusan National University)H-Index: 27
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BACKGROUND Previous studies have shown that Echinococcus granulosus cystic fluid can alleviate Th2 allergic airway inflammatory responses by increasing the number of CD4+ CD25+ Foxp3+ T (regulatory T; Treg) cells. Parasite-derived extracellular vesicles (EV) are known to not only promote parasite infection by communicating between parasites but also regulate the inflammatory response by acting as an immunomodulatory agent in the host. METHODS To evaluate the effect of EV extracted from the cysti...
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Protease-activated receptor 2 (PAR2) is a member of G-protein-coupled receptors and affects ligand-modulated calcium signaling. Although PAR2 signaling promotes obesity and adipose tissue inflammation in high fat- (HF-) fed conditions, its role in adipocyte differentiation under nonobesogenic conditions needs to be elucidated. Here, we used several tissues and primary-cultured adipocytes of mice lacking PAR2 to study its role in the development of adipose tissues. C57BL/6J mice with PAR2 deficie...
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#1Min Seung Kang (PNU: Pusan National University)H-Index: 1
#2Lee JongSoo (PNU: Pusan National University)
Last. Ji Eun Lee (PNU: Pusan National University)H-Index: 19
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PURPOSE To evaluate whether allergic conjunctivitis (AC) could be induced by Acanthamoeba excretory-secretory protein (ESP) and analyze the therapeutic effect of resolvin (Rv) D1 and antiallergic agents. METHODS Human conjunctival epithelial cells (HCVCs) were treated with 10 µg/well of ESP, and Th2 cytokines were measured using real-time PCR. C57BL/6 mice were treated with 10 µg/5 µL of ESP after sensitization, and conjunctivas isolated from the mice were stained with hematoxylin and eosin (H&E...
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#1Byeong Moo Kim (PNU: Pusan National University)H-Index: 1
#2Dae Hyun Kim (PNU: Pusan National University)H-Index: 25
Last. Hae Young Chung (PNU: Pusan National University)H-Index: 86
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Protease-activated receptor 2 (PAR2) is a member of G protein-coupled receptors. There are two types of PAR2 signaling pathways: canonical G-protein signaling and β-arrestin signaling. Although PAR2 signaling has been reported to aggravate hepatic steatosis, the exact mechanism is still unclear, and the role of PAR2 in autophagy remains unknown. In this study, we investigated the regulatory role of PAR2 in autophagy during high-fat diet (HFD)-induced hepatic steatosis in mice. Increased protein ...
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#1Shin Ae Kang (PNU: Pusan National University)H-Index: 12
#2Hak Sun Yu (PNU: Pusan National University)H-Index: 27
AIMS Helminth infection typically induces a Th2 inflammatory response that is characterized by eosinophilia, high levels of IgE, and mast cells. LTB4 is generated from innate immune cells, such as neutrophils, macrophages, and mast cells, in response to a range of stimuli. It mainly acts on myeloid leukocytes, inducing the activation of integrins, adhesion to endothelium walls, and chemotaxis. METHODS AND RESULTS The objective of the present study was to determine the role of the LTB4 receptor i...
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#1Kalahe Hewage Iresha Nadeeka Madushani Herath (Jeju National University)H-Index: 7
#2Hyo Jin Kim (Jeju National University)H-Index: 2
Last. Youngheun Jee (Jeju National University)H-Index: 27
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ETHNOPHARMACOLOGICAL RELEVANCE Sargassum horneri (Turner) C. Agardh (S. horneri), an edible brown marine algae, is known to have immunomodulatory effects and has been used in oriental medicine to treat inflammatory diseases. It is well known that ambient particulate matter (PM) is closely related to increased respiratory diseases inducing lung inflammation. AIM Considering the use of Sargassum horneri in traditional medicine to treat inflammatory diseases, we hypothesized and investigated the us...
2 CitationsSource
#1Ji Yun Her (PNU: Pusan National University)H-Index: 2
#2Yunna Lee (PNU: Pusan National University)H-Index: 5
Last. Eunok Im (PNU: Pusan National University)H-Index: 26
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Protease-activated receptor 2 (PAR2) regulates inflammatory responses and lipid metabolism. However, its precise role in colitis remains unclear. Here, we aimed to investigate the function of PAR2 in high-fat diet fed mice with colitis and its potential role in autophagy. PAR2+/+ and PAR2-/- mice were fed a high-fat diet (HFD) for 7 days before colitis induction with dextran sodium sulfate. Deletion of PAR2 and a HFD significantly exacerbated colitis as shown by increased mortality, body weight ...
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#1Shin Ae Kang (PNU: Pusan National University)H-Index: 12
#2Jun Ho Choi (PNU: Pusan National University)H-Index: 3
Last. Hak Sun Yu (PNU: Pusan National University)H-Index: 27
view all 6 authors...
Abstract Obesity is an increasingly prevalent disease worldwide, and genetic and environmental factors are known to regulate the development of obesity and associated metabolic diseases. Emerging studies indicate that innate and adaptive immune cell responses in adipose tissue play critical roles in the regulation of metabolic homeostasis. Parasitic helminths are the strongest natural inducers of type 2 inflammatory responses, and several studies have revealed that helminth infections inversely ...
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#1Jae-Ho Bae (PNU: Pusan National University)
Last. Hak Sun YuH-Index: 27
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Strongyloidiasis is caused by Strongyloides stercoralis and is one of the most neglected tropical diseases in tropical and subtropical regions. Although several strongyloidiasis cases have been reported in Korea, genetic analysis of Korean isolates is still incomplete. In this study, a parasite was isolated from a 61-year-old man diagnosed with strongyloidiasis during the treatment of lymphoma on his retroperitoneal lymph node. Diffuse symmetric wall thickening from the ascending to descending c...
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#1Kyung-Wan Baek (PNU: Pusan National University)H-Index: 6
#2Da-In Lee (PNU: Pusan National University)H-Index: 5
Last. Ji-Seok Kim (Gyeongsang National University)H-Index: 4
view all 8 authors...
Abstract In the adipose tissue (AT), an increase in the M1 macrophage (M1O)/M2 macrophage (M2O) polarization ratio can be a risk factor enhancing the inflammatory response during aging, as well as increasing the risk of chronic disease, thereby reducing lifespan, or at least reducing “healthy” lifespan. The purpose of this study was to analyze and compare the AT M1O/M2O polarization ratio at the final lifespan stage in aged and control animals performing lifelong spontaneous wheel running. Based...
1 CitationsSource