Osamu Miura
Tokyo Medical and Dental University
PhosphorylationSurgeryPathologyMolecular biologyCytotoxic T cellChemistryImmunologyVirusHematopoietic stem cell transplantationTyrosine phosphorylationLeukemiaCRKLLymphomaErythropoietin receptorTyrosine kinaseCancer researchMedicineBiologyGastroenterologyCell biology
199Publications
31H-index
4,035Citations
Publications 187
Newest
#1Masayuki NagasawaH-Index: 20
#2Noriko Mitsuiki (Tokyo Medical and Dental University)H-Index: 10
Last. Tomohiro Morio (Tokyo Medical and Dental University)H-Index: 46
view all 10 authors...
We have recently reported a new method for detecting T-cell-derived extracellular vesicles (EVs), CD3+CD4+EVs,CD3+CD8+EVs, and CD3+HLA-DR+EVs. In our previous study, CD3+HLA-DR+EVs were released profusely by CD8+T cells, only moderately by T helper1 (Th1) CD4+T cells, and very little from Th2 CD4+T cells in vitro. EVs were measured sequentially in patients undergoing hematopoietic stem cell transplantation (HSCT), and their relationship to GVHD was investigated in comparison with other conventio...
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#1Satoru Aoyama (Tokyo Medical and Dental University)
#2Shunichiro Yasuda (Tokyo Medical and Dental University)H-Index: 4
Last. Norihiko Kawamata (Tokyo Medical and Dental University)H-Index: 37
view all 8 authors...
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#1Ichiro Yonese (Tokyo Medical and Dental University)H-Index: 1
#2Chizuko Sakashita (Tokyo Medical and Dental University)H-Index: 5
Last. Ayako Arai (Tokyo Medical and Dental University)H-Index: 22
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Systemic chronic active Epstein-Barr virus infection (sCAEBV) was defined as a T- or NK-cell neoplasm in the 2017 World Health Organization (WHO) classification. To clarify the clinical features of sCAEBV under this classification and review the effects of chemotherapy, we performed a nationwide survey in Japan from 2016 through 2018 of patients with sCAEBV newly diagnosed from January 2003 through March 2016. One hundred cases were evaluated. The patients were aged 1 to 78 years (median, 21) an...
3 CitationsSource
#1Kouhei Yamamoto (Tokyo Medical and Dental University)H-Index: 14
#2Shinya Abe (Tokyo Medical and Dental University)H-Index: 14
Last. Masanobu Kitagawa (Tokyo Medical and Dental University)H-Index: 32
view all 12 authors...
Cancer cells, including malignant lymphoma cells, alter their metabolism, termed “metabolic reprograming,” on initiation of malignant transformation as well as upon accumulation of genetic abnormalities. Here, to identify a novel therapeutic target involved in the metabolic changes during malignant lymphoma, we performed global analyses combined with shotgun proteomics, in silico database analysis, and clinic-pathologic analysis of nonneoplastic lymphoid tissue and malignant lymphoma tissue and ...
2 CitationsSource
#1Ayako Arai (Tokyo Medical and Dental University)H-Index: 22
#2Hiroshi Takase (Tokyo Medical and Dental University)H-Index: 25
Last. Osamu Miura (Tokyo Medical and Dental University)H-Index: 31
view all 6 authors...
The characteristics of tumor cells of primary vitreoretinal lymphoma (PVRL) have not been defined, although researches have shown that most cases are of diffuse large B-cell lymphoma (DLBCL). To determine the subtype and biological characteristics of tumor cells of PVRL, we performed a gene expression profiling analysis. RNA was extracted from the vitreous fluid of 7 PVRL patients and from nodal samples of 10 DLBCL patients: 6 of germinal center B-cell (GCB) type and 4 of activated B-cell (ABC) ...
1 CitationsSource
#1Ayako Nogami (Tokyo Medical and Dental University)H-Index: 7
#2Masahide Yamamoto (Tokyo Medical and Dental University)H-Index: 10
Last. Tetsuya Fukuda (Tokyo Medical and Dental University)H-Index: 21
view all 8 authors...
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#1Satoshi Koi (Tokyo Medical and Dental University)
#2Kosuke Arai (Tokyo Medical and Dental University)
Last. Toshikage Nagao (Tokyo Medical and Dental University)H-Index: 7
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#1Shunichiro Yasuda (Tokyo Medical and Dental University)H-Index: 4
#2Satoru Aoyama (Tokyo Medical and Dental University)
Last. Norihiko Kawamata (Tokyo Medical and Dental University)H-Index: 37
view all 16 authors...
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#1Satoru Aoyama (Tokyo Medical and Dental University)
#2Shunichiro Yasuda (Tokyo Medical and Dental University)H-Index: 4
Last. Norihiko Kawamata (Tokyo Medical and Dental University)H-Index: 37
view all 8 authors...
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#1Kota Yoshifuji (Tokyo Medical and Dental University)H-Index: 5
#2Yoshihiro Umezawa (Tokyo Medical and Dental University)H-Index: 6
Last. Masahide Yamamoto (Tokyo Medical and Dental University)H-Index: 10
view all 6 authors...
BACKGROUND/AIM: Methotrexate (MTX)-associated classical Hodgkin lymphoma (CHL) is a rare disease, and its prognosis remains unclear. MATERIALS AND METHODS: Our study retrospectively compared clinicopathological features and clinical outcomes of patients with MTX-CHL (n=6) and sporadic CHL (n=40). RESULTS: MTX-CHL was more frequently the mixed cellularity subtype and positive for Epstein-Barr virus, but less frequently positive for CD20 than sporadic CHL. Clinically, MTX-CHL was more frequent in ...
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