Haruhito Sugiyama
Nagasaki University
Internal medicineRadiologySurgeryPathologyOncologyChemistryImmunologyAsthmaLung cancerBronchial thermoplastyEosinophilRheumatoid arthritisLungBronchoscopyPleural effusionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)AnesthesiaMedicineGastroenterology
171Publications
19H-index
1,266Citations
Publications 171
Newest
#1Akinari TsukadaH-Index: 1
#2Manabu SuzukiH-Index: 5
Last. Haruhito SugiyamaH-Index: 19
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We herein report a 67-year-old kidney transplant patient who died of COVID-19. He was treated with hydroxychloroquine and azithromycin and received mechanical ventilation that temporarily improved his respiratory status. Despite our efforts, however, he later developed respiratory failure and died 43 days after the disease onset. The autopsy revealed prominent organization of alveoli and alveolar ducts, with a massive accumulation of macrophages in the lungs. A few SARS-CoV-2 antigen-positive ce...
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#1Shohei Yamamoto (Kitasato University)H-Index: 3
#2Akihito TanakaH-Index: 1
Last. Norio OhmagariH-Index: 24
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#1Shohei YamamotoH-Index: 3
#2Akihito TanakaH-Index: 1
Last. Norio OhmagariH-Index: 7
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We assessed the consistency of seropositive results of three rapid immunoassays (Kits A, B, and C) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared to highly accurate serological tests (Abbott and Roche) among healthcare workers in a hospital in Tokyo. The seroprevalence of SARS-CoV-2 immunoglobulin G was 0.41%, 2.36%, and 0.08% using Kits A, B, and C, respectively. Of the 51 samples that were seropositive on any rapid test, all were seronegative on both the Abbott and t...
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#1Sho SaitoH-Index: 7
#2Kayoko HayakawaH-Index: 4
Last. Norio OhmagariH-Index: 7
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Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originating in Wuhan, China, has spread globally very rapidly. The number of COVID-19 patients increased in Japan from late March to early April 2020. Since COVID-19 treatment methods with antiviral drugs were not established in March 2020, clinical trials began at a rapid pace worldwide. We participated in a global investigator-initiated clinical trial of the antiviral drug remdesivir. It took...
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#1Masayuki HojoH-Index: 1
Last. Haruhito SugiyamaH-Index: 19
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Angiotensin converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2), two receptors on the cell membrane of bronchial epithelial cells, are indispensable for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. ACE2 receptor is increased among aged, males, and smokers. As smoking upsurges ACE2 expression, chronic obstructive pulmonary disease (COPD) patients are prone to SARS-CoV-2 infection, and are at a higher risk for severe forms of COVID-19 (coronavirus di...
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The rapid global spread of the COVID-19 pandemic has posed a significant challenge to various countries in terms of the capacity of hospitals to admit and care for patients during the crisis. To estimate hospital capacity during the COVID-19 pandemic, clinicians working in tertiary hospitals around the world were surveyed regarding available COVID-19 hospital statistics. Data were obtained from 8 tertiary centers in 8 countries including the United States, United Kingdom, Switzerland, Turkey, Si...
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#1Kazuma Yagi (Keio: Keio University)H-Index: 11
#2Akihiro ItoH-Index: 1
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RATIONALE The clinical features and prognosis of nontuberculous mycobacterial (NTM) pleuritis and pleural effusion combined with NTM lung disease (NTM-LD) remain unclear. OBJECTIVES To investigate the clinical features and prognosis of NTM pleuritis. METHODS This retrospective observational study included patients with NTM pleuritis from January 2001 to June 2018 across eight hospitals in Japan. NTM pleuritis was defined by a positive culture of NTM from pleural effusion. We matched patients wit...
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#1Takashi KatsunoH-Index: 2
#2Manabu SuzukiH-Index: 5
Last. Haruhito SugiyamaH-Index: 19
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#1Yoshie TsujimotoH-Index: 2
#2Junko TeradaH-Index: 1
Last. Haruhito SugiyamaH-Index: 19
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BACKGROUND: The current gold standard in coronavirus disease (COVID-19) diagnostics is the real-time reverse transcription-polymerase chain reaction (RT-PCR) assay for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in nasopharyngeal swab (NPS) samples. Alternatively, nasal swab (NS) or saliva swab (SS) specimens are used, although available data on test accuracy are limited. We examined the diagnostic accuracy of NPS/NS/SS samples for this purpose. METHODS: Ten patien...
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#2Manabu SuzukiH-Index: 5
Last. Haruhito SugiyamaH-Index: 19
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A 62-year-old woman with rheumatoid arthritis and a history of receiving immunosuppressant therapy had a recurrence of lung adenocarcinoma with EGFR L858R mutation. Following 14 months of treatment with erlotinib, computed tomography (CT) findings revealed the presence of small diffuse nodules. Bronchoscopy was performed as metastasis was suspected; however, this was not detected on lung biopsy with forceps. Transbronchial lung cryobiopsy (TBLC) succeeded in detecting metastatic adenocarcinoma, ...
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