Hossein Ghanbarian
Shahid Beheshti University of Medical Sciences and Health Services
GenemicroRNAGene expressionMolecular biologyChemistryMesenchymal stem cellMicrovesiclesStem cellTranscription (biology)Tissue engineeringCancer researchGeneticsRNAMedicineCell cultureBiologyScaffoldCell biology
55Publications
16H-index
928Citations
Publications 48
Newest
#1Neda MokhberianH-Index: 3
#2Kazem SharifiH-Index: 9
Last. Hossein GhanbarianH-Index: 16
view all 8 authors...
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#1Yalda Khazaei-Poul (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 4
#2Samaneh Shojaei (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 1
Last. Samira Mohammadi-Yeganeh (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 14
view all 5 authors...
AIMS Deregulation of microRNA (miRNA) function has been linked to numerous human cancers, such as Triple Negative Breast Cancer (TNBC). Exosomes, a subgroup of extracellular vehicles (EVs), can efficiently deliver many different cargo types to the target cell and have an extensive role in delivering therapeutic cargo for treatment. The present study intended to interrogate the effects of exosomal delivery of miR-3182 on TNBC cellular processes. MAIN METHODS Human Umbilical Cord Mesenchymal Stem ...
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#1Shahin Aghamiri (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 5
#2Farshid Zandsalimi (Tehran University of Medical Sciences)H-Index: 3
Last. Hossein Ghanbarian (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 16
view all 11 authors...
Breast cancer is the most common and deadliest cancer in women worldwide. Although notable advances have been achieved in the treatment of breast cancer, the overall survival rate of metastatic breast cancer patients is still considerably low due to the development of resistance to breast cancer chemotherapeutic agents and the non-optimal specificity of the current generation of cancer medications. Hence, there is a growing interest in the search for alternative therapeutics with novel anticance...
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#1Shahin Aghamiri (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 5
#2Pourya Raee (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 4
Last. Shohreh Farhadi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 5
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The serious drawbacks of the conventional treatment of pancreatic ductal adenocarcinoma (PDAC) such as nonspecific toxicity and high resistance to chemo and radiation therapy, have prompted the development and application of countless small interfering RNA (siRNA)-based therapeutics. Recent advances in drug delivery systems hold great promise for improving siRNA-based therapeutics and developing a new class of drugs, known as nano-siRNA drugs. However, many fundamental questions, regarding toxic...
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#1Ramazan RezaeiH-Index: 7
#2Kaveh BaghaeiH-Index: 11
Last. Davar AmaniH-Index: 8
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Exosomes have been introduced as a new alternative delivery system for the transmission of small molecules. Tumor-derived exosomes (TEXs) not only contain tumor-associated antigens to stimulate antitumor immune responses but also act as natural carriers of microRNAs. The aim of the current study was to evaluate the efficacy of miR-124-3p-enriched TEX (TEXomiR) as cell-free vaccine in the induction of antitumor immune responses in a mouse model of colorectal cancer. Briefly, the exosomes were iso...
2 CitationsSource
#1Hossein GhanbarianH-Index: 16
#2Shahin AghamiriH-Index: 5
Last. Kay-Dietrich WagnerH-Index: 30
view all 5 authors...
Small double-strand RNA (dsRNA) molecules can activate endogenous genes via an RNA-based promoter targeting mechanism. RNA activation (RNAa) is an evolutionarily conserved mechanism present in diverse eukaryotic organisms ranging from nematodes to humans. Small activating RNAs (saRNAs) involved in RNAa have been successfully used to activate gene expression in cultured cells, and thereby this emergent technique might allow us to develop various biotechnological applications, without the need to ...
1 CitationsSource
#1Akram Jalali (Shahid Beheshti University of Medical Sciences and Health Services)
#2Mojgan Bandehpour (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 18
Last. Bahram Kazemi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 30
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Producing a functional anti-IL-2Rα antibody in Leishmania tarentolae, a trypanosomatid protozoan non-pathogenic to human, is a cost-effective and safe alternative for the production of therapeutic recombinant proteins. Expression cassettes encoding heavy and light chains of the anti-IL-2Rα antibody were cloned into two separate pLEXSY vectors. The plasmids were then used to transfect L. tarentolae laboratory strain p10 and stable expression of a recombinant humanized anti-IL-2Rα antibody was obt...
1 CitationsSource
#2Maryam HajizadehH-Index: 4
Last. Jafar KianiH-Index: 10
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#5Mohammad Saied Salehi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 9
Recent investigations have emphasized the role of aberrant expression of microRNAs (miRNAs) in progression of almost all types of cancers. Exosomes, membrane-enclosed natural nanovesicles, transport cellular contents, including proteins, mRNAs, and miRNAs, between cells. Unique features of exosomes make them an appropriate carrier for drug delivery. miRNA-381 is one of the downregulated miRNAs in several cancers including triple-negative breast cancer (TNBC) and restoration of its expression in ...
1 CitationsSource
#1Zohreh Lasjerdi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 12
#2Hossein Ghanbarian (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 16
Last. Ali Haghighi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 24
view all 10 authors...
Background Cutaneous Leishmaniasis (CL) is an emerging uncontrollable and neglected infectious disease worldwide including Iran. The aim of this study was to investigate the expression profile of apoptosis-related miRNA and its target gene in macrophages. Methods This study was carried out in the Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran from January 2016 to November 2018. Applying literature reviews, bioinfo...
4 CitationsSource