Luciana Cicco
University of Bari
Surface modificationMedicinal chemistryCatalysisOrganic chemistryEutectic systemChemistryAnhydrousMaterials scienceCombinatorial chemistryTetrahydropyranCholine chlorideProtonolysisDeep eutectic solventSolventReagentYield (chemistry)RegioselectivityPhotochemistryGreen chemistryGroup 2 organometallic chemistry
28Publications
7H-index
266Citations
Publications 26
Newest
#1Paola Vitale (University of Bari)H-Index: 22
#2Luciana Cicco (University of Bari)H-Index: 7
Last. Vito Capriati (University of Bari)H-Index: 32
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Alkoxide-mediated enolization of 1-arylpropan-2-ones and their fluorinated derivatives, followed by α-functionalization with nucleophilic addition and substitution reactions, has been accomplished in the environmentally friendly eutectic mixture choline chloride/urea, under aerobic conditions. The usefulness of this new protocol has also been exemplified through the synthesis of a small selection of building-block like molecules through Pd-catalyzed α-arylation reactions.
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#2Luciana CiccoH-Index: 7
Last. Vito CapriatiH-Index: 32
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#1Luciana CiccoH-Index: 7
#2Giuseppe DilauroH-Index: 7
Last. Vito CapriatiH-Index: 32
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Owing to a growing awareness towards environmental impact, the search for “greener”, safer, and cost-effective solvents able to replace petroleum-derived solvents has never been greater today. In this context, the use of environmentally responsible solvents like water and the so-called Deep Eutectic Solvents (DESs), constructed from bio-based compounds, has recently experienced important growth in several fields of sciences. This short review highlights the key features of the chemistry of water...
13 CitationsSource
#1Luciana Cicco (University of Bari)H-Index: 7
#2José A Hernández-Fernández (University of Oviedo)H-Index: 2
Last. Joaquín García-Álvarez (University of Oviedo)H-Index: 30
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An efficient and selective N-functionalization of amides is first reported via a CuI-catalyzed Goldberg-type C-N coupling reaction between aryl iodides and primary/secondary amides run either in Deep Eutectic Solvents (DESs) or water as sustainable reaction media, under mild and bench-type reaction conditions (absence of protecting atmosphere). Higher activities were observed in an aqueous medium, though the employment of DESs expanded and improved the scope of the reaction to include also aliph...
4 CitationsSource
#1Luciana CiccoH-Index: 7
Last. Joaquín García-ÁlvarezH-Index: 30
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#2Luciana Cicco (University of Bari)H-Index: 7
Last. Javier González-SabínH-Index: 22
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The Meyer-Schuster rearrangement of propargylic alcohols into α,β-unsaturated carbonyl compounds has been revisited by setting up an atom-economic process catalyzed by a deep eutectic solvent FeCl3·6H2O/glycerol. Isomerizations take place smoothly, at room temperature, under air and with short reaction times. The unique solubilizing properties of the eutectic mixture enabled the use of a substrate concentration up to 1.0 M with the medium being recycled up to ten runs without any loss of catalyt...
4 CitationsSource
#1Luciana Cicco (University of Bari)H-Index: 7
#2Alba Fombona‐Pascual (University of Oviedo)H-Index: 1
Last. Joaquín García-Álvarez (CSIC: Spanish National Research Council)H-Index: 30
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Highly polarized lithium phosphides (LiPR2 ) were synthesized, for the first time, in deep eutectic solvents as sustainable reaction media, at room temperature and in the absence of protecting atmosphere, through direct deprotonation of both aliphatic and aromatic secondary phosphines (HPR2 ) by n-BuLi. The subsequent addition of in-situ generated LiPR2 to aldehydes or epoxides proceeded quickly and chemoselectively, thereby allowing the straightforward access to the corresponding α- or β-hydrox...
9 CitationsSource
#1Paola Vitale (University of Bari)H-Index: 22
#2Luciana Cicco (University of Bari)H-Index: 7
Last. Vito Capriati (University of Bari)H-Index: 32
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We report that phenacyl azides are key compounds for a regiodivergent synthesis of valuable, functionalized imidazole (32–98% yield) and pyrimidine derivatives (45–88% yield), with a broad substrate scope, when using deep eutectic solvents [choline chloride (ChCl)/glycerol (1:2 mol/mol) and ChCl/urea (1:2 mol/mol)] as environmentally benign and non-innocent reaction media, by modulating the temperature (25 or 80 °C) in the presence or absence of bases (Et3N).
4 CitationsSource
#1Luciana CiccoH-Index: 7
#2Antonio SalomoneH-Index: 21
Last. Vito CapriatiH-Index: 32
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: We first report that highly polarized organometallic compounds of s-block elements add smoothly to chiral N - tert -butanesulfinyl imines in the biodegradable D-sorbitol/choline chloride eutectic mixture, thereby granting access to enantioenriched amines after quantitatively deblocking the sulfinyl group. The practicability of the methodology was further highlighted by (a) working at ambient temperature and under air, (b) very short reaction times (2 min), (c) the preparation of diastereomeric...
13 CitationsSource
#1Luciana Cicco (University of Bari)H-Index: 7
#2Antonio SalomoneH-Index: 21
Last. Vito Capriati (University of Bari)H-Index: 32
view all 8 authors...
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