Nunggum Jung
Kyung Hee University
EndocrinologyStem cell transplantation for articular cartilage repairChemistryApoptosisMesenchymal stem cellSubstance PVascular endothelial growth factorDermal fibroblastNOD miceStreptozotocinInsulitisPancreatic isletsBone marrowWound healingAngiogenesisType 1 diabetesStem cellPopulationDiabetes mellitusCell biology
5Publications
4H-index
35Citations
Publications 5
Newest
#1Jihyun Um (Kyung Hee University)H-Index: 6
#2Nunggum Jung (Kyung Hee University)H-Index: 4
Last. Ki-Sook ParkH-Index: 18
view all 7 authors...
Abstract Preservation of pancreatic β-cells is required for the development of therapies for type 1 and type 2 diabetes (T1D and T2D, respectively). Our previous study demonstrated that substance P (SP) preserves β-cell populations in mice with streptozotocin-induced T1D. Here, we demonstrated that chronic systemic treatment with SP restored the mass of β-cells both in nonobese diabetic (NOD) mice with T1D or db/db mice with T2D. SP delayed the onset of T1D in NOD mice via immune modulation. SP ...
3 CitationsSource
#1Nunggum Jung (Kyung Hee University)H-Index: 4
#2Jihyun Um (Kyung Hee University)H-Index: 6
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 8 authors...
Abstract Preservation of the pancreatic β-cell population is required for the development of therapies for diabetes, which is caused by a decrease in β-cells. Here, we demonstrate the antidiabetic effects of substance P (SP) in type 1 diabetes (T1D) mice induced with streptozotocin. SP enhanced the compensatory proliferation of β-cells in order to restore β-cells in response to acute injury induced by a single high-dose of streptozotocin. However, SP affected neither the basal proliferation of β...
5 CitationsSource
#1Nunggum Jung (Kyung Hee University)H-Index: 4
#2Jinyeong Yu (Kyung Hee University)H-Index: 5
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 5 authors...
Dermal fibroblasts play essential roles in wound healing. However, they lose their normal regenerative functions under certain pathologic conditions such as in chronic diabetic wounds. Here, we show that substance P (SP) rescues the malfunctions of dermal fibroblasts in diabetes. SP increased the proliferation of diabetic dermal fibroblasts dose-dependently, although the effect was lower compared to the SP-stimulated proliferation of normal dermal fibroblasts. In contrast to normal dermal fibrob...
4 CitationsSource
#1Jihyun Um (Kyung Hee University)H-Index: 6
#2Nunggum Jung (Kyung Hee University)H-Index: 4
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 6 authors...
Wound healing is essential for the survival and tissue homeostasis of unicellular and multicellular organisms. The current study demonstrated that the neuropeptide substance P (SP) accelerated the wound healing process, particularly in the skin. Subcutaneous treatment of SP accelerated wound closing, increased the population of α-smooth muscle actin positive myofibroblasts, and increased extracellular matrix deposition at the wound site. Moreover, SP treatment enhances angiogenesis without a loc...
16 CitationsSource
#1Maria Jose Dubon (Kyung Hee University)H-Index: 6
#2Yeji Byeon (Kyung Hee University)H-Index: 3
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 5 authors...
Bone marrow derived mesenchymal stem cells (MSCs) have self-renewal characteristics and are able to differentiate into various cell types. These cells can mobilize to peripheral tissues in order to participate in important biological processes such as wound healing. They are also able to regulate hematopoietic stem cells (HSCs) trafficking between the bone marrow and the periphery through the regulation of intercellular interactions and the expression of cytokines, such as SDF-1. Previous studie...
4 CitationsSource