Sateesh Alavala
Indian Institute of Chemical Technology
CytotoxicityInternal medicineCellulaseProinflammatory cytokineTumor necrosis factor alphaChemistryApoptosisGlycosideInflammationGalanginHeLaInflammatory bowel diseaseSteviosideCytokineAnti-inflammatoryUlcerative colitisStevia rebaudianaBiochemistryMedicinePharmacology
10Publications
6H-index
79Citations
Publications 10
Newest
#1Rajendra SangarajuH-Index: 3
#2Sateesh AlavalaH-Index: 6
Last. Ramakrishna Sistla (AcSIR: Academy of Scientific and Innovative Research)H-Index: 1
view all 5 authors...
1 CitationsSource
#1Sateesh Alavala (Indian Institute of Chemical Technology)H-Index: 6
#2Nasiruddin Nalban (Indian Institute of Chemical Technology)H-Index: 3
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 7 authors...
Adjuvant arthritis is a chronic, autoimmune and inflammatory disorder of the joints. The occurrence of disorder causes a severe damage to the connective tissue eventually leading to progressive physical disability and eventual death. The recent years of evidence suggests the anti-inflammatory properties of stevioside, a diterpene glycoside. However, the effect of stevioside against adjuvant arthritis, a chronic inflammatory disorder is not known. Hence, the present study was designed to study th...
5 CitationsSource
#1Nasiruddin Nalban (Indian Institute of Chemical Technology)H-Index: 3
#2Rajendra Sangaraju (Indian Institute of Chemical Technology)H-Index: 3
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 6 authors...
Arbutin is a glycoside reported for its anti-oxidant, anti-inflammatory and anti-tumor properties. However, the cardioprotective effect of Arbutin is not well established. The study aims to understand the effect of arbutin on isoproterenol (ISO)-induced cardiac hypertrophy in mice. The animals were pretreated with Arbutin for a week and ISO was administered for 10 days and then sacrificed. Cardiac injury markers such as creatinine kinase and lactate dehydrogenase concentrations were measured in ...
8 CitationsSource
#1Sateesh Alavala (Indian Institute of Chemical Technology)H-Index: 6
#2Rajendra Sangaraju (Indian Institute of Chemical Technology)H-Index: 3
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 7 authors...
Abstract: Inflammatory bowel disease is an umbrella-term used to describe a set of chronic inflammatory conditions that affect the gastro-intestinal tract. Since most of the inflammatory medications in current use have several undesirable side-effects, stevioside, a naturally occurring, high-intensity sweetener was assessed in our study for its anti-inflammatory properties by in-vitro and in-vivo experiments. Stevioside was observed to significantly inhibit the levels of LPS induced elevation of...
15 CitationsSource
#1Rajendra Sangaraju (Indian Institute of Chemical Technology)H-Index: 3
#2Nasiruddin Nalban (Indian Institute of Chemical Technology)H-Index: 3
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 6 authors...
Objective and design Inflammatory bowel disease (IBD) is known to cause chronic inflammation in the digestive tract by the immune malfunction. Herein, we demonstrate the protective effect of galangin (GAL), a phytochemical, on LPS-induced inflammation in cultured mouse macrophages (RAW 264.7) and the treatment of DSS-induced ulcerative colitis in Balb/c mice. However, the anti-inflammatory effect of GAL in DSS-exposed experimental colitis has not been investigated.
14 CitationsSource
#1Burri Nagaraju (Indian Institute of Chemical Technology)H-Index: 8
#2Jeshma Kovvuri (Indian Institute of Chemical Technology)H-Index: 8
Last. Ahmed Kamal (Jamia Hamdard)H-Index: 11
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Abstract A series of new pyrazole linked benzothiazole-β-naphthol derivatives were designed and synthesized using a simple, efficient and ecofriendly route under catalyst-free conditions in good to excellent yields. These derivatives were evaluated for their cytotoxicity on selected human cancer cell lines. Among those, the derivatives 4j, 4k and 4l exhibited considerable cytotoxicity with IC50 values ranging between 4.63 and 5.54 µM against human cervical cancer cells (HeLa). Structure activity...
13 CitationsSource
#1Nasiruddin Nalban (Indian Institute of Chemical Technology)H-Index: 3
#2Sateesh Alavala (Indian Institute of Chemical Technology)H-Index: 6
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 5 authors...
Asthma and chronic obstructive pulmonary disease (COPD) are the common respiratory diseases posing immense burden on human health. Incidence of asthma and COPD are increasing significantly in recent decade around the world. There is abundant evidence that these disorders are mediated by oxidative stress which plays a key role in the initiation and augmentation of inflammation. Currently available western drugs are associated with severe side effects and resistance, and hence, there is a need of ...
1 CitationsSource
#1M. P. Narasimha Rao (Indian Institute of Chemical Technology)H-Index: 10
#2Burri Nagaraju (Indian Institute of Chemical Technology)H-Index: 8
Last. Nishant Jain (Indian Institute of Chemical Technology)H-Index: 22
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Abstract A series of imidazo[2,1-b][1,3,4]thiadiazole linked indolinone conjugates were synthesized and investigated for antiproliferative activity in different human cancer cell lines by changing various substitutions at indolinone and phenyl ring systems. Among them conjugates 7, 14 and 15 were exhibited potent antiproliferative activity with GI50 values from 0.13 to 3.8 μΜ and evaluated for cell cycle analysis, tubulin polymerization assay and apoptosis. Treatment with 7, 14 and 15 were resul...
11 CitationsSource
#1Bhaskar Rao Adari (Indian Institute of Chemical Technology)H-Index: 2
#2Sateesh Alavala (Indian Institute of Chemical Technology)H-Index: 6
Last. Akella V. S. Sarma (Indian Institute of Chemical Technology)H-Index: 16
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Abstract Rebaudioside-A is the second most abundant sweet diterpene glycoside (1–3%) present in the leaves of Stevia rebaudiana Bertoni, and is now being considered as a possible sucrose substitute due to its pleasant organoleptic properties and associated health benefits. In the present study, a novel in situ enzymatic transglycosylation of stevioside has been developed by pre-treating the stevia leaves with cellulase and adding soluble starch as the glucosyl donor. The results confirm that the...
25 CitationsSource
Stevioside, extracted from the leaves of Stevia rebaudiana Bertoni, is a natural, high intensity, lowcaloric sweetener with wide therapeutic activities. Conventional stevioside extraction methodologies involve the use of non-green solvents, supercritical fluids, microwaves, etc., however, all these processes are expensive, time-consuming and eco-unfriendly. Therefore an alternative process is desired for the isolation of stevioside. In this study, a novel enzyme-mediated extraction (EME) method ...
6 CitationsSource