Sadayoshi Ito
Tohoku University
Internal medicineUrologyEndocrinologySurgeryPathologyRenal functionCardiologyChemistryRenin–angiotensin systemOxidative stressAldosteroneKidney diseaseDiabetic nephropathyKidneyPrimary aldosteronismAngiotensin IIDiabetes mellitusMedicineBlood pressureBiologyPharmacology
822Publications
94H-index
23.9kCitations
Publications 830
Newest
#1Hiroyasu Iso (Osaka University)H-Index: 104
#2Renzhe Cui (Osaka University)H-Index: 22
Last. Takashi Kadowaki (UTokyo: University of Tokyo)H-Index: 158
view all 26 authors...
Background It is uncertain whether risk classification under the nationwide program on screening and lifestyle modification for metabolic syndrome captures well high-risk individuals who could benefit from lifestyle interventions. We examined the validity of risk classification by linking the incidence of cardiovascular disease (CVD). Methods and Results Individual-level data of 29 288 Japanese individuals aged 40 to 74 years without a history of CVD from 10 prospective cohort studies were used....
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#1Kazuomi Kario (Jichi Medical University)H-Index: 76
#2Sadayoshi Ito (Tohoku University)H-Index: 94
Last. Satoru Yamakawa (Daiichi Sankyo)H-Index: 4
view all 6 authors...
There are limited data on the nighttime blood pressure (BP)-lowering effect of esaxerenone and its effect on N-terminal pro b-type natriuretic peptide (NT-proBNP), a predictor of cardiovascular risk, according to different dipping patterns of nocturnal BP. This was a post hoc analysis of a multicenter, open-label, long-term phase 3 study of esaxerenone, a new highly selective mineralocorticoid receptor blocker, in patients with essential hypertension. Patients were classified by dipping pattern ...
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#1Kei AsayamaH-Index: 59
#2Takayoshi OhkuboH-Index: 101
Last. Satoshi UmemuraH-Index: 68
view all 14 authors...
OBJECTIVE The aim was to compare short-term and long-term reproducibilities of in-office unattended blood pressure (BP), namely automated office blood pressure (AOBP), conventionally measured attended office BP, and self-measured home BP. METHODS A multicentre, clinical study was conducted in Japan, and 287 Japanese outpatients on antihypertensive drug medication were followed-up for 1 year. RESULTS The intensity of drug treatment was sustained consistently throughout the study period (defined d...
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#1Junichiro Hashimoto (Miyagi University of Education)H-Index: 59
#2Kaname TagawaH-Index: 4
Last. Sadayoshi ItoH-Index: 94
view all 4 authors...
OBJECTIVE Blood pressure fluctuates during diastole to create a dicrotic wave but the mechanistic origin remains poorly understood. We sought to investigate the characteristics and determinants of diastolic pressure and flow fluctuations with a focus on stiffness gradients between the central aorta and peripheral arteries. METHODS Using applanation tonometry and duplex ultrasound, pulse waveforms were recorded on the femoral artery in 592 patients (age: 55 ± 14 years) to estimate the diastolic p...
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#1Nobuyuki TakahashiH-Index: 17
#2Akiyo SekimotoH-Index: 7
Last. Hiroshi SatoH-Index: 63
view all 6 authors...
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Electrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes mellitus (T2DM) remains unclear. This study aimed to investigate the effect of EHW on T2DM. This was a multicenter, prospective, double-blind, randomized controlled trial of 50 patients with T2DM who were assigned to the EHW or filtered water (FW) groups. The primary endpoint was changes in insulin resistance (IR) evaluated using the homeostasis model asse...
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#1Hiroko Ogata (Tohoku University)H-Index: 3
#2Yuto Yamazaki (Tohoku University)H-Index: 14
Last. Norio WadaH-Index: 16
view all 29 authors...
The rapid progression of chronic kidney disease and higher incidence of cardiovascular complications are well known in patients with hyperaldosteronism. However, detailed renal histopathologic characteristics of this disease have remained unknown. Therefore, renal biopsy specimens of 19 cases with unilateral hyperaldosteronism were compared with 22 autopsy renal cases of estimated glomerular filtration rate-matched essential hypertension without nephropathy or endocrine disorders to explore the ...
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#1Sadayoshi Ito (Tohoku University)H-Index: 94
#2Naoki Kashihara (Kawasaki Medical School)H-Index: 43
Last. Tomoko Sawanobori (Daiichi Sankyo)H-Index: 2
view all 7 authors...
BACKGROUND Esaxerenone has potential renoprotective effects and reduces the urinary albumin-to-creatinine ratio (UACR) in patients with diabetic kidney disease and overt nephropathy. We investigated the efficacy and safety of esaxerenone in Japanese patients with type 2 diabetes (T2D) and macroalbuminuria (UACR ≥ 300 mg/g creatinine). METHODS We conducted a multicenter, single-arm, open-label phase III study in 56 patients with T2D and UACR ≥ 300 mg/g creatinine with estimated glomerular filtrat...
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Patients with chronic kidney disease (CKD) commonly exhibit hypercoagulability. Increased levels of uremic toxins cause thrombogenicity by increasing tissue factor (TF) expression and activating the extrinsic coagulation cascade. TF is induced in monocytes and macrophages under pathological conditions, such as inflammatory diseases. However, the role of monocyte myeloid cell TF in CKD progression remains unclear. We aimed to clarify this issue, and the present study found that patients with CKD ...
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#1Kazuomi Kario (Jichi Medical University)H-Index: 76
#2Sadayoshi Ito (Tohoku University)H-Index: 94
Last. Satoru Yamakawa (Daiichi Sankyo)H-Index: 4
view all 7 authors...
Background Nocturnal hypertension is an important phenotype of abnormal diurnal blood pressure (BP) variability and a known risk marker for target organ damage and cardiovascular events. This study aimed to assess the differential BP-lowering effects of esaxerenone vs. eplerenone on nocturnal BP in hypertensive patients with different nocturnal dipping patterns. Methods This was a post hoc analysis of the "Esaxerenone (CS-3150) Compared to Eplerenone in Patients with Essential Hypertension" stud...
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