J. Peter Rubin
University of Pittsburgh
AnatomyRegenerative medicineInternal medicineEndocrinologyBiomedical engineeringSoft tissuePlastic surgerySurgeryPathologyRegeneration (biology)Adipose tissueMesenchymal stem cellBody contouringStromal vascular fractionAbdominoplastyStem cellPopulationFat graftingTransplantationTissue engineeringWeight lossMedicineBiologyCell biology
Publications 273
#1Wakako TsujiH-Index: 12
#2Jolene E. ValentinH-Index: 9
Last. J. Peter RubinH-Index: 60
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: Autologous fat grafting after breast cancer surgery is commonly performed, but concerns about oncologic risk remain. To model the interaction between fat grafting and breast cancer cells, two approaches were employed. In the first approach, graded numbers of viable MDA-MB-231 or BT-474 cells were admixed directly into human fat grafts and injected subcutaneously into immune-deficient mice to determine if the healing graft is a supportive environment for the tumor. In the second approach, grade...
9 CitationsSource
#1Lauren E. KokaiH-Index: 14
#2Taraneh JonesH-Index: 1
Last. J. Peter RubinH-Index: 60
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Background: Animal models are often used to assess interventions that might improve fat grafting outcomes; however, there is great variability in the models. The authors sought to determine the predictive value of the immunocompromised mouse model for fat grafting so that experiments could be standardized and optimized. Methods: Human lipoaspirate injections at different volumes and time points were assessed in a nude mouse model and compared with control injections of nonviable fat. Volume rete...
2 CitationsSource
#1Arta Kelmendi-Doko (University of Pittsburgh)H-Index: 4
#2J. Peter Rubin (University of Pittsburgh)H-Index: 60
Last. Kacey G. Marra (University of Pittsburgh)H-Index: 64
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Current materials used for adipose tissue reconstruction have critical shortcomings such as suboptimal volume retention, donor-site morbidity, and poor biocompatibility. The aim of this study was t...
5 CitationsSource
#1Jeffrey T. Krawiec (University of Pittsburgh)H-Index: 5
#2Han-Tsung Liao (University of Pittsburgh)H-Index: 2
Last. David A. VorpH-Index: 61
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Abstract Objective One of the rate-limiting barriers within the field of vascular tissue engineering is the lengthy fabrication time associated with expanding appropriate cell types in culture. One particularly attractive cell type for this purpose is the adipose-derived mesenchymal stem cell (AD-MSC), which is abundant and easily harvested from liposuction procedures. Even this cell type has its drawbacks, however, including the required culture period for expansion, which could pose risks of c...
18 CitationsSource
#1Christopher Mahoney (University of Pittsburgh)H-Index: 6
#2Arta Kelmindi-Doko (University of Pittsburgh)H-Index: 1
Last. Kacey G. Marra (University of Pittsburgh)H-Index: 64
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Abstract Hydrogels derived from adipose tissue extracellular matrix (AdECM) have shown potential in the ability to generate new adipose tissue in vivo . To further enhance adipogenesis, a composite adipose derived delivery system (CADDS) containing single- and double-walled dexamethasone encapsulated microspheres (SW and DW Dex MS) has been developed. Previously, our laboratory has published the use of Dex MS as an additive to enhance adipogenesis and angiogenesis in adipose tissue grafts. In th...
5 CitationsSource
#1Sharona Czerniak (University of Pittsburgh)H-Index: 1
#2Jeffrey A. Gusenoff (University of Pittsburgh)H-Index: 21
Last. J. Peter Rubin (University of Pittsburgh)H-Index: 60
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#1Sheri Wang (University of Pittsburgh)H-Index: 4
#2Daibang Nie (University of Pittsburgh)H-Index: 1
Last. Lauren E. Kokai (University of Pittsburgh)H-Index: 14
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Abstract Background: Secondary lymphedema, resulting from damage to lymphatic vessels, is a common sequela following surgical removal of lymph nodes for cancer. Current therapeutics for treating lymphedema are limited and further research on underlying causes is warranted. Published studies on molecular mechanisms of lymphedema primarily focus on lymphatic endothelial cells (LECs), which comprise the innermost lining of lymphatic capillaries and collecting vessels. However, traditional static cu...
4 CitationsSource
1 CitationsSource