J. Peter Rubin
University of Pittsburgh
Regenerative medicineInternal medicineBiomedical engineeringSoft tissuePlastic surgerySurgeryPathologyAdipose tissueMesenchymal stem cellBody contouringStromal vascular fractionStem cellPopulationFat graftingTransplantationTissue engineeringWeight lossMedicineBiologyCell biology
Publications 273
#1Amy L. Strong (NYU: New York University)H-Index: 19
#2Paul S. CedernaH-Index: 35
Last. Benjamin LeviH-Index: 31
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Abstract Interest in and acceptance of autologous fat grafting for use in contour abnormalities, breast reconstruction, and cosmetic procedures have increased. However, there are many procedural variations that alter the effectiveness of the procedure and may account for the unpredictable resorption rates observed. The authors highlighted studies investigating the effects of harvesting procedures, processing techniques, and reinjection methods on the survival of fat grafts. This review focused o...
133 CitationsSource
#1Latha Satish (University of Pittsburgh)H-Index: 19
#2J. Michael Krill-Burger (University of Pittsburgh)H-Index: 2
Last. J. Peter Rubin (University of Pittsburgh)H-Index: 60
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Background Adipose tissue-derived stromal stem cells (ASCs) represent a promising regenerative resource for soft tissue reconstruction. Although autologous grafting of whole fat has long been practiced, a major clinical limitation of this technique is inconsistent long-term graft retention. To understand the changes in cell function during the transition of ASCs into fully mature fat cells, we compared the transcriptome profiles of cultured undifferentiated human primary ASCs under conditions le...
26 CitationsSource
#1Albert D. Donnenberg (University of Pittsburgh)H-Index: 27
#2E. Michael Meyer (University of Pittsburgh)H-Index: 8
Last. Vera S. Donnenberg (University of Pittsburgh)H-Index: 28
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In this technical note we describe a method to evaluate the cell surface proteome of human primary cell cultures and cell lines. The method utilizes the BD Biosciences lyoplate, a system covering 242 surface proteins, glycoproteins, and glycosphingolipids plus relevant isotype controls, automated plate-based flow cytometry, conventional file-level analysis and unsupervised K-means clustering of markers on the basis of percent of positive events and mean fluorescence intensity of positive and tot...
19 CitationsSource
#1Joseph P. Hunstad (UNC: University of North Carolina at Chapel Hill)H-Index: 14
#2Joseph MichaelsH-Index: 11
Last. J. Peter Rubin (University of Pittsburgh)H-Index: 60
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Objective To evaluate the safety and effectiveness of a lysine-derived urethane adhesive as a noninvasive alternative to closed suction drains in a commonly performed large flap surgical procedure.
8 CitationsSource
#1Joseph Michaels (University of Pittsburgh)H-Index: 7
#2Devin CoonH-Index: 22
Last. J. Peter Rubin (University of Pittsburgh)H-Index: 60
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BACKGROUND: Measures that can reduce the incidence of venous thromboembolism (VTE) are of great clinical importance. In addition to the use of sequential compression devices (SCDs), chemoprophylaxis with low-molecular-weight heparin (LMWH) has been recommended by the American College of Chest Physicians for major general surgery procedures. There remains inconclusive evidence to support guidelines for the plastic surgery population, and some surgeons hesitate to use anticoagulation due to concer...
7 CitationsSource
#1Riccardo Schweizer (University of Pittsburgh)H-Index: 14
#2Wakako TsujiH-Index: 12
Last. Jan A. Plock (UZH: University of Zurich)H-Index: 23
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Conventional breast cancer extirpation involves resection of parts of or the whole gland, resulting in asymmetry and disfiguration. Given the unsatisfactory aesthetic outcomes, patients often desire postmastectomy reconstructive procedures. Autologous fat grafting has been proposed for reconstructive purposes for decades to restore form and anatomy after mastectomy. Fat has the inherent advantage of being autologous tissue and the most natural-appearing filler, but given its inconsistent engraft...
51 CitationsSource
#1Wakako Tsuji (University of Pittsburgh)H-Index: 12
#2Jonas T. Schnider (University of Pittsburgh)H-Index: 11
Last. Vijay S. Gorantla (University of Pittsburgh)H-Index: 27
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The immunomodulatory potential of cell therapies using adipose-derived stem cells (ASCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs) has been studied in vascularized composite allotransplantation (VCA). Most cell therapy-based experimental and clinical protocols integrate some degree of recipient conditioning/induction with antibodies or other immunosuppressive agents. We investigated the susceptibility of ASCs and BM-MSCs to anti-lymphocyte serum (ALS) and tacrolimus. Rat ASCs and ...
17 CitationsSource
#1Danielle M. Minteer (University of Pittsburgh)H-Index: 9
#2Kacey G. Marra (University of Pittsburgh)H-Index: 64
Last. J. Peter Rubin (University of Pittsburgh)H-Index: 60
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Abstract This article discusses adipose-derived stem cell (ASC) biology, describes the current knowledge in the literature for the safety and regulation of ASCs, and provides a brief overview of the regenerative potential of ASCs. It is not an exhaustive listing of all available clinical studies or every study applying ASCs in tissue engineering and regenerative medicine, but is an objective commentary of these topics.
57 CitationsSource
#1Sanjay NaranH-Index: 17
#2Sameer ShakirH-Index: 8
Last. Vu T. NguyenH-Index: 13
view all 10 authors...
#1Kyle E. Freese (University of Pittsburgh)H-Index: 6
#2Lauren E. Kokai (University of Pittsburgh)H-Index: 14
Last. Faina Linkov (University of Pittsburgh)H-Index: 20
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Obesity is a well recognized risk factor for several types of cancers, many of which occur solely or disproportionately in women. Adipose tissue is a rich source of adipose-derived stem cells (ASC), which have received attention for their role in cancer behavior. The purpose of this systematic review is to present the existing literature on the role of ASCs in the growth, development, progression, and metastasis of cancer, with an emphasis on malignancies that primarily affect women. To accompli...
71 CitationsSource