Hartmut Jaeschke
University of Kansas
Internal medicineEndocrinologyPathologyMolecular biologyChemistryApoptosisImmunologyOxidative stressLiver injuryInflammationAcetaminophenMitochondrionToxicityProgrammed cell deathNecrosisGlutathioneBiochemistryMedicineBiologyCell biologyPharmacology
440Publications
122H-index
30.9kCitations
Publications 447
Newest
#1Hui Qian (KU: University of Kansas)H-Index: 4
#2Qingyun Bai (Yichun University)H-Index: 1
Last. Wen-Xing Ding (KU: University of Kansas)H-Index: 64
view all 11 authors...
Abstract null null Acetaminophen (APAP) overdose can induce liver injury and is the most frequent cause of acute liver failure in the United States. We investigated the role of P62/SQSTM1 (referred to as P62) in APAP-induced liver injury (AILI) in mice. We found that the hepatic protein levels of P62 dramatically increased at 24 h after APAP treatment, which was inversely correlated with the hepatic levels of APAP-adducts. APAP also activated mTOR at 24 h, which is associated with increased cell...
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#1Nga T. Nguyen (KU: University of Kansas)H-Index: 4
#2David S Umbaugh (KU: University of Kansas)H-Index: 3
Last. Hartmut Jaeschke (KU: University of Kansas)H-Index: 122
view all 5 authors...
Acetaminophen (APAP) is a widely used analgesic, but also a main cause of acute liver injury in the United States and many western countries. APAP hepatotoxicity is associated with a sterile inflammatory response as shown by the infiltration of neutrophils and monocytes. While the contribution of the immune cells to promote liver repair have been demonstrated, the direct interactions between macrophages or neutrophils with hepatocytes to help facilitate hepatocyte proliferation and tissue repair...
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#1D. R. Robarts (University of Kansas Hospital)
Last. Udayan ApteH-Index: 37
view all 14 authors...
The liver has a unique capacity to regenerate after injury in a highly orchestrated and regulated manner. Here we report that O-GlcNAcylation, an intracellular post-translational modification (PTM) regulated by two enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), is a critical termination signal for liver regeneration (LR) following partial hepatectomy (PHX). We studied liver regeneration after PHX on hepatocyte specific OGT and OGA knockout mice (OGT-KO and OGA-KO), which caused a sig...
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#1Hartmut Jaeschke (KU: University of Kansas)H-Index: 122
#2Olamide B Adelusi (KU: University of Kansas)H-Index: 1
Last. Anup Ramachandran (KU: University of Kansas)H-Index: 57
view all 8 authors...
Abstract null null Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human pathophysiology. As a result, this clinically relevant model is frequently used to study mechanisms of drug-induced liver injury and even more so to test potential therapeutic interventions. However, the complexity of the model req...
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Overdose of acetaminophen (APAP) is the major cause of acute liver failure in the Western world with very limited treatment options. Previous studies from our groups and others have shown that timely activation of liver regeneration is a critical determinant of transplant free survival of APAP-induced acute liver failure (ALF) patients. Here we report that hepatocyte specific deletion of Yes associated protein (Yap), the downstream mediator of the Hippo Kinase signaling pathway results in faster...
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#1Hartmut JaeschkeH-Index: 122
#2Jephte Y. AkakpoH-Index: 10
Last. Anup RamachandranH-Index: 57
view all 3 authors...
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#1Jephte Y. Akakpo (KU: University of Kansas)H-Index: 10
#2Matthew W Jaeschke (KU: University of Kansas)H-Index: 1
Last. Hartmut Jaeschke (KU: University of Kansas)H-Index: 122
view all 6 authors...
N-acetylcysteine (NAC) is the only clinically approved antidote against acetaminophen (APAP) hepatotoxicity. Despite its efficacy in patients treated early after APAP overdose, NAC has been implicated in impairing liver recovery in mice. More recently, 4-methylpyrazole (4MP, Fomepizole) emerged as a potential antidote in the mouse APAP hepatotoxicity model. The objective of this manuscript was to verify the detrimental effect of NAC and its potential mechanism and assess whether 4MP has the same...
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#1David S Umbaugh (KU: University of Kansas)H-Index: 3
#2Anup Ramachandran (KU: University of Kansas)H-Index: 57
Last. Hartmut Jaeschke (KU: University of Kansas)H-Index: 122
view all 3 authors...
An acetaminophen (APAP) overdose is the most common cause of acute liver failure in the United States. A hallmark characteristic of APAP hepatotoxicity is centrilobular necrosis. General, innate mechanisms such as lower amounts of GSH and higher Cyp2e1 expression in pericentral (PC) hepatocytes are known to contribute to the differences in susceptibility to cell injury between periportal (PP) hepatocytes and PC hepatocytes. While a sequence of molecular events involving formation of the reactive...
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#1Anup Ramachandran (KU: University of Kansas)H-Index: 57
#2Hartmut Jaeschke (KU: University of Kansas)H-Index: 122
Significance: Acetaminophen (APAP) is one of the quantitively most consumed drugs worldwide. Although safe at therapeutic doses, intentional or unintentional overdosing occurs frequently causing se...
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