Anurag K. Singh
Roswell Park Cancer Institute
CancerInternal medicineRadiologySurgeryOncologyStage (cooking)ChemistryLung cancerHead and neck cancerChemotherapyStereotactic body radiation therapyNuclear medicineRadiation therapyMedicineCohort
Publications 331
#1Johnny Kao (Good Samaritan Hospital Medical Center)H-Index: 29
#2Mark K. Farrugia (Roswell Park Cancer Institute)H-Index: 8
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BACKGROUND Patients with metastatic cancer referred to radiation oncology have diverse prognoses and there is significant interest in personalizing treatment. We hypothesized that patients selected for higher biologically equivalent doses have improved overall survival. METHODS The study population consists of 355 consecutive adult patients with distant metastases treated by a single radiation oncologist from 2014 to 2018. The validated NEAT model was used to prospectively stratify patients into...
#1Sung Jun Ma (Roswell Park Cancer Institute)H-Index: 7
#2Lucas M. Serra (SUNY: State University of New York System)H-Index: 4
Last. Anurag K. Singh (Roswell Park Cancer Institute)H-Index: 36
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To evaluate the association of various gene expression assays with pathologic complete response (pCR) in the setting of neoadjuvant chemotherapy among patients with breast cancer The National Cancer Database (NCDB) was queried for women diagnosed between 2010 and 2017 with stage I-III breast cancer who underwent neoadjuvant chemotherapy and either 21-gene recurrence score (RS) or 70-gene signature (GS). Logistic multivariable analysis (MVA) was performed to identify variables associated with pCR...
#1Han YuH-Index: 1
#2Sung Jun MaH-Index: 7
Last. Jon M. ChanH-Index: 1
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Prognostication for cancer patients is integral for patient counseling and treatment planning, yet providing accurate prediction can be challenging using existing patient-specific clinical indicators and host factors. In this work, we evaluated common machine learning models in predicting head and neck squamous cell carcinoma (HNSCC) patients’ overall survival based on demographic, clinical features and host factors. We found random survival forest had best performance among the models evaluated...
#1Mark K. FarrugiaH-Index: 8
#2Han YuH-Index: 1
Last. Anurag K. SinghH-Index: 36
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The association between HRQOL metrics and survival has not been studied in early stage non-small-cell lung cancer (NSCLC) patients undergoing SBRT. The cohort was derived via a post-hoc analysis of a prospective randomized clinical trial examining definitive SBRT for peripheral, early-stage NSCLC with a single or multi-fraction regimen. Patients completed HRQOL questionnaires prior to and 3 months after treatment. Using principal component analysis (PCA), changes in each HRQOL scale following tr...
#1Anurag K. Singh (Roswell Park Cancer Institute)H-Index: 36
#2Jacob M. Sands (Roswell Park Cancer Institute)
#1Amy L. ShaverH-Index: 6
#2Katia NoyesH-Index: 36
Last. Mary E. PlatekH-Index: 17
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Head and neck cancer (HNC) treatment-related morbidity can be detrimental to quality of life (QOL). Myosteatosis is associated with poor QOL in multiple cancers. If predictive of poor QOL trajectories, myosteatosis would be a tool for clinicians to determine which patients may require additional support during treatment. The purpose of this study was to determine if pretreatment myosteatosis is associated with a poor QOL trajectory following treatment completion. Methods: In a retrospective coho...
#1Anurag K. SinghH-Index: 36
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#1Mark K. FarrugiaH-Index: 8
#2Sung Jun MaH-Index: 7
Last. Simon Fung-Kee-FungH-Index: 9
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The preferred radiotherapeutic approach for central (CLT) and ultracentral (UCLT) lung tumors is unclear. We assessed the toxicity and outcomes of patients with CLT and UCLT who underwent definitive five-fraction stereotactic body radiation therapy (SBRT). We reviewed the charts of patients with either CLT or UCLT managed with SBRT from June 2010–April 2019. CLT were defined as gross tumor volume (GTV) within 2 cm of either the proximal bronchial tree, trachea, mediastinum, aorta, or spinal cord...
#1Fangyi Gu (Roswell Park Cancer Institute)H-Index: 5
#2Eduardo Cortes Gomez (Roswell Park Cancer Institute)H-Index: 10
Last. Christine B. Ambrosone (Roswell Park Cancer Institute)H-Index: 86
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Background To address a critical gap for application of cancer chronotherapy of when would be the best time(s) for treating an individual cancer patient, we conducted a pilot study to characterize diurnal variations of gene expression in oral mucosal tissue, which is vulnerable to damage from cancer therapies. Methods We conducted RNA-seq assay on individual oral mucosal samples collected from 11 healthy volunteers every 4 hours (6 time points). Using a cosine-based method, we estimated the indi...
#1Mark K. Farrugia (SUNY: State University of New York System)H-Index: 8
#2Han Yu (Roswell Park Cancer Institute)H-Index: 1
Last. Anurag K. Singh (Roswell Park Cancer Institute)H-Index: 36
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BACKGROUND Financial toxicity (FT) can be devastating to cancer patients, and solutions are urgently needed. We investigated the impact of financial counseling (FC) on FT in head and neck cancer (HNC) patients. METHODS Via a single-institution database, we reviewed the charts of HNC patients who underwent definitive or post-operative radiotherapy, from October 2013 to December 2020. Of these patients, 387 had provided baseline and post-treatment information regarding financial difficulty. In Jul...