Heng-Ye Man
Boston University
Synaptic scalingPhosphorylationSynaptic fatigueHippocampal formationAMPA receptorNeuroscienceReceptorChemistryMaterials scienceMetaplasticityPostsynaptic potentialNeurotransmissionLong-term potentiationNonsynaptic plasticityNeuronHippocampusLong-term depressionBiologyCell biologySynaptic plasticity
99Publications
32H-index
5,759Citations
Publications 98
Newest
#1Sheng Xiao (BU: Boston University)H-Index: 5
#2Eric Lowet (BU: Boston University)H-Index: 10
Last. Christoph Straub (College of Osteopathic Medicine of the Pacific)
view all 14 authors...
Abstract null null Recent improvements in genetically encoded voltage indicators enabled optical imaging of action potentials and subthreshold transmembrane voltage in vivo. To perform high speed voltage imaging of many neurons simultaneously over a large anatomical area, widefield microscopy remains an essential tool. However, the lack of optical sectioning makes widefield microscopy prone to background cross-contamination. We implemented a digital micromirror device based targeted illumination...
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#1Linli Shi (BU: Boston University)H-Index: 1
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 74
view all 9 authors...
Neuromodulation at high spatial resolution poses great significance in advancing fundamental knowledge in the field of neuroscience and offering novel clinical treatments. Here, we developed a tapered fiber optoacoustic emitter (TFOE) generating an ultrasound field with a high spatial precision of 39.6 µm, enabling optoacoustic activation of single neurons or subcellular structures, such as axons and dendrites. Temporally, a single acoustic pulse of sub-microsecond converted by the TFOE from a s...
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#1Leticia Pérez-Sisqués (University of Barcelona)H-Index: 2
#2Núria Martín-Flores (University of Barcelona)H-Index: 6
Last. Cristina Malagelada (University of Barcelona)H-Index: 18
view all 20 authors...
Abstract Background RTP801/REDD1 is a stress-regulated protein whose upregulation is necessary and sufficient to trigger neuronal death in in vitro and in vivo models of Parkinson's and Huntington's diseases and is up regulated in compromised neurons in human postmortem brains of both neurodegenerative disorders. Indeed, in both Parkinson's and Huntington's disease mouse models, RTP801 knockdown alleviates motor-learning deficits. Results We investigated the physiological role of RTP801 in neuro...
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#1Mei Ma (HUST: Huazhong University of Science and Technology)H-Index: 2
#2Wan Xiong (HUST: Huazhong University of Science and Technology)H-Index: 5
Last. Ling-Qiang Zhu (HUST: Huazhong University of Science and Technology)H-Index: 34
view all 9 authors...
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#1Sheng Xiao (BU: Boston University)H-Index: 5
#2Eric Lowet (BU: Boston University)H-Index: 10
Last. Xue HanH-Index: 28
view all 11 authors...
Recent improvements in genetically encoded voltage indicators enabled high precision imaging of single neurons action potentials and subthreshold membrane voltage dynamics in the mammalian brain. To perform high speed voltage imaging, widefield microscopy remains an essential tool to record activity from many neurons simultaneously over a large anatomical area. However, the lack of optical sectioning makes widefield microscopy prone to background signal contamination. We implemented a simple, lo...
Source
#1Kai Zheng (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Fan Hu (HUST: Huazhong University of Science and Technology)H-Index: 6
Last. Ling-Qiang Zhu (HUST: Huazhong University of Science and Technology)H-Index: 34
view all 16 authors...
Aberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis of Alzheimer's disease (AD), but most abnormally expressed miRNAs found in AD are not regulated by synaptic activity. Here we report that dysfunction of miR-135a-5p/Rock2/Add1 results in memory/synaptic disorder in a mouse model of AD. miR-135a-5p levels are significantly reduced in excitatory hippocampal neurons of AD model mice. This decrease is tau dependent and mediated by Foxd3. Inhibition of miR-135a-5p leads...
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#1Ying Jiang (BU: Boston University)H-Index: 4
#2Yimin Huang (BU: Boston University)H-Index: 10
Last. Lu Lan (BU: Boston University)H-Index: 14
view all 15 authors...
Summary Neuromodulation is an invaluable approach for the study of neural circuits and clinical treatment of neurological diseases. Here, we report semiconducting polymer nanoparticles based photoacoustic nanotransducers (PANs) for neural stimulation in vitro and in vivo. Our PANs strongly absorb the nanosecond pulsed laser in the near-infrared second window (NIR-II) and generate localized acoustic waves. PANs are shown to be surface modified and selectively bind onto neurons. PAN-mediated activ...
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#7Jing Wang (HUST: Huazhong University of Science and Technology)H-Index: 246
Iron homeostasis disturbance has been implicated in Alzheimer's disease (AD), and excess iron exacerbates oxidative damage and cognitive defects. Ferroptosis is a nonapoptotic form of cell death dependent upon intracellular iron. However, the involvement of ferroptosis in the pathogenesis of AD remains elusive. Here, we report that ferroportin1 (Fpn), the only identified mammalian nonheme iron exporter, was downregulated in the brains of APPswe/PS1dE9 mice as an Alzheimer's mouse model and Alzhe...
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#1Linli Shi (BU: Boston University)H-Index: 1
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 74
view all 9 authors...
As an emerging technology, transcranial focused ultrasound has been demonstrated to successfully evoke motor responses in mice, rabbits, and sensory/motor responses in humans. Yet, the spatial resolution of ultrasound does not allow for high-precision stimulation. Here, we developed a tapered fiber optoacoustic emitter (TFOE) for optoacoustic stimulation of neurons with an unprecedented spatial resolution of 20 microns, enabling selective activation of single neurons or subcellular structures, s...
#1Margaret O'Connor (BU: Boston University)H-Index: 28
#2Yang-Ping Shentu (HUST: Huazhong University of Science and Technology)H-Index: 4
Last. Heng-Ye Man (BU: Boston University)H-Index: 32
view all 8 authors...
In Alzheimer's disease (AD), decreases in the amount and synaptic localization of AMPA receptors (AMPARs) result in weakened synaptic activity and dysfunction in synaptic plasticity, leading to impairments in cognitive functions. We have previously found that AMPARs are subject to lysine acetylation, resulting in higher AMPAR stability and protein accumulation. Here we report that AMPAR acetylation was significantly reduced in AD and neurons with Aβ incubation. We identified p300 as the acetyltr...
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