Petros Perros
Royal Victoria Infirmary
Internal medicineEndocrinologySurgeryPathologyIntensive care medicinePediatricsImmunologyLevothyroxineEye diseaseGraves' diseaseEuthyroidDiseaseMEDLINEThyroid cancerPopulationIn patientThyroidDiabetes mellitusMedicineGastroenterology
Publications 216
#1Tomasz Bednarczuk (Medical University of Warsaw)H-Index: 23
#2Roberto AttanasioH-Index: 24
Last. Marek Ruchała (Poznan University of Medical Sciences)H-Index: 22
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Introduction: Over the past several years new evidence on management of hypothyroidism has emerged and has influenced recommendations from professional bodies. The presentation of hypothyroid patients has also changed and increasingly new cases are diagnosed by indiscriminate screening often identifying cases with minor biochemical disturbances. Little is known about the physician responses and attitudes to this changing landscape. THESIS (Treatment of Hypothyroidism in Europe by Specialists: an...
#1Alla ShepelkevichH-Index: 4
#2Yuliya DydyshkaH-Index: 1
Last. Petros PerrosH-Index: 59
view all 10 authors...
#1Yuliya DydyshkaH-Index: 1
#2Alla ShepelkevichH-Index: 4
Last. Petros PerrosH-Index: 59
view all 10 authors...
Last. Steen Joop BonnemaH-Index: 37
view all 9 authors...
#1Petros Perros (RVI: Royal Victoria Infirmary)H-Index: 59
#2Christina M. van der Feltz-Cornelis (Ebor: University of York)H-Index: 34
Last. Laszlo Hegedüs (OUH: Odense University Hospital)H-Index: 89
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A significant minority of patients with hypothyroidism report persistent symptoms despite achieving normal thyroid biochemistry after levothyroxine (L-T4) replacement. Four principal lines of thinking, which are not mutually exclusive, may explain this enigma. The "low tissue liothyronine hypothesis" emphasises the potential imperfections of L-T4 replacement therapy, that may lead to hypothyroidism in some tissues like the brain, while others (for example hypothalamus) are euthyroid. The "Somati...
2 CitationsSource
#1Kamilla Ryom Riis (OUH: Odense University Hospital)
#1K. R. Riis (OUH: Odense University Hospital)
Last. Steen Joop Bonnema (OUH: Odense University Hospital)H-Index: 37
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PURPOSE The standard treatment of hypothyroidism is levothyroxine (LT4), which is available as tablets or soft-gel capsules in Denmark. This study aimed to investigate Danish endocrinologists' use of thyroid hormones in hypothyroid and euthyroid patients. METHODS An e-mail with an invitation to participate in an online survey investigating practices about substitution with thyroid hormones was sent to all members of the Danish Endocrine Society (DES). RESULTS Out of 488 eligible DES members, a t...
#1Anna L. Mitchell (British Thyroid Foundation)H-Index: 18
#2Laszlo Hegedüs (OUH: Odense University Hospital)H-Index: 89
Last. Petros Perros (British Thyroid Foundation)H-Index: 59
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OBJECTIVE Dissatisfaction with treatment and impaired quality of life (QOL) are reported among people with treated hypothyroidism. We aimed to gain insight into this. DESIGN AND PATIENTS We conducted an online survey of individuals with self-reported hypothyroidism. RESULTS Nine hundred sixty-nine responses were analysed. Dissatisfaction with treatment was common (77.6%), and overall QOL scores were low. Patient satisfaction did not correlate with type of thyroid hormone treatment, but treatment...
4 CitationsSource
#1Endre Nagy (University of Debrecen)H-Index: 27
#1E. Nagy (University of Debrecen)H-Index: 119
Last. Laszlo Hegedüs (OUH: Odense University Hospital)H-Index: 89
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Background: Levothyroxine (LT4) as a medication is used by up to 5.3% of the adult population. For optimal efficacy, the traditional tablet formulation (LT4tab) requires that patients avoid concomi...
3 CitationsSource
#1Petros Perros (Freeman Hospital)H-Index: 59
#2Krishnarajah Nirantharakumar (University of Birmingham)H-Index: 23
Last. Laszlo Hegedüs (University of Southern Denmark)H-Index: 89
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Since the introduction of sensitive assays for serum thyroid stimulating hormone (TSH) clinicians have advised hypothyroid patients to adjust the dose of levothyroxine (L-T4) in order to achieve a normal serum TSH. A minority of patients are dissatisfied with this treatment strategy and experience symptoms. Some indirect evidence suggests that a normal serum TSH may not necessarily reflect euthyroidism at tissue level in patients treated with L-T4. Increasingly hypothyroid patients demand higher...
#1Miloš Žarković (University of Belgrade)H-Index: 8
#2W. M. Wiersinga (UvA: University of Amsterdam)H-Index: 34
Last. Thomas Heiberg Brix (University of Southern Denmark)H-Index: 39
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PURPOSE Whereas antithyroid drugs (ATD) are the preferred treatment modality for Graves' hyperthyroidism (GH), there is still controversy about the optimal regimen for delivering ATD. To evaluate whether 'Block and Replace' (B + R) and 'Titration' (T) regimes are equivalent in terms of frequency of euthyroidism and Graves' Orbitopathy (GO) during ATD therapy. METHODS A prospective multicentre observational cohort study of 344 patients with GH but no GO at baseline. Patients were treated with ATD...
3 CitationsSource