Motohisa Yamamoto
Sapporo Medical University
PathologyAntibodyDermatologyRheumatologyImmunologyBiopsyRetroperitoneal fibrosisPrednisoloneRheumatoid arthritisInfiltration (medical)Autoimmune pancreatitisDacryoadenitisKidney diseaseSialadenitisDiseaseIgG4-related diseaseFibrosisPathogenesisMedicineGastroenterology
Publications 149
#1Noritada Yoshikawa (UTokyo: University of Tokyo)H-Index: 18
#2Aya Oda (UTokyo: University of Tokyo)H-Index: 3
Last. Hirotoshi Tanaka (UTokyo: University of Tokyo)H-Index: 45
view all 7 authors...
Skeletal muscle functions as a locomotory system and maintains whole-body metabolism. Sex differences in such skeletal muscle morphology and function have been documented; however, their underlying mechanisms remain elusive. Glucocorticoids are adrenocortical hormones maintaining homeostasis, including regulating whole-body energy metabolism in addition to stress response. In skeletal muscle, glucocorticoids can reduce the synthesis of muscle proteins and simultaneously accelerate the breakdown ...
#1Hiroki Yamazaki (UTokyo: University of Tokyo)H-Index: 6
#1Hiroki Yamazaki (UTokyo: University of Tokyo)H-Index: 4
Last. Hirotoshi Tanaka (UTokyo: University of Tokyo)H-Index: 45
view all 8 authors...
2 CitationsSource
#1Hayato Yabe (Sapporo Medical University)H-Index: 3
#2Ryuta Kamekura (Sapporo Medical University)H-Index: 19
Last. Shingo Ichimiya (Sapporo Medical University)H-Index: 28
view all 12 authors...
AbstractObjectives: The aim of this study was to determine pathological features of T peripheral helper (Tph)-like (PD-1+CXCR5−CD4+ T) cells in IgG4-related disease (IgG4-RD).Methods: Tph-like cell...
5 CitationsSource
#1Yuhei Fujisawa (Kanazawa University)H-Index: 2
#2Ichiro Mizushima (Kanazawa University)H-Index: 12
Last. Mitsuhiro Kawano (Kanazawa University)H-Index: 21
view all 14 authors...
AbstractObjectives: This study investigated the clinical features of IgG4-RKD patients with hypocomplementemia compared with those without it, so as to clarify the factors related to hypocomplement...
1 CitationsSource
#1Noritada Yoshikawa (UTokyo: University of Tokyo)H-Index: 18
#2Erika Matsubara (UTokyo: University of Tokyo)H-Index: 2
Last. Hirotoshi Tanaka (UTokyo: University of Tokyo)H-Index: 45
view all 7 authors...
A 65-year-old Japanese woman, who was diagnosed with rheumatoid arthritis and Sjogren's syndrome with various autoantibodies including anti-DNA antibody, developed bullous pemphigoid and hematological abnormalities like lupus erythematosus after adalimumab therapy. The discontinuation of adalimumab resolved those disorders but polyarthritis thereafter relapsed. The introduction of abatacept was not effective, but tocilizumab was found to be effective for polyarthritis, however, thereafter both b...
#1Takuji Nakamura (Kanazawa Medical University)H-Index: 9
#2Tomomi Satoh-Nakamura (Kanazawa Medical University)H-Index: 2
Last. Hisanori Umehara (Kanazawa Medical University)H-Index: 43
view all 28 authors...
AbstractBackground: IgG4-related disease (IgG4-RD) is characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. The pathogenesis of this disease is not clear. Tran...
#1Motohisa Yamamoto (UTokyo: University of Tokyo)H-Index: 35
#2Noritada Yoshikawa (UTokyo: University of Tokyo)H-Index: 18
Last. Hirotoshi Tanaka (UTokyo: University of Tokyo)H-Index: 45
view all 3 authors...
We read with great interest the article from Simpson et al on the clinical efficacy of dupilumab in a patient with IgG4-related disease (IgG4-RD).1 Glucocorticoid is currently the first-line induction therapy for IgG4-RD.2 Since it generally suppresses acquired immune cells, we could not know the therapeutic targets in IgG4-RD. So far, the efficacy of rituximab, targeting B cells, has been discussed,3 but we reconfirm that type 2 helper T (Th2) cells can be one of the therapeutic targets in IgG4...
#1Ima Kosukegawa (Sapporo Medical University)H-Index: 5
#2Shunichiro Okazaki (Memorial Hospital of South Bend)
Last. Toshihiko Yamashita (Sapporo Medical University)H-Index: 39
view all 8 authors...
Background An effective prevention strategy for osteonecrosis of the femoral head (ONFH) has yet to be established. We previously reported that the innate immune system via the toll-like receptor (TLR) response induced by corticosteroids leads to the development of ONFH and that repression of IRF7 activity by an inhibitor could interfere with the development of ONFH while maintaining the therapeutic effect of the corticosteroids.
#1Ichiro Mizushima (Kanazawa University)H-Index: 12
#2Satomi Kasashima (Kanazawa University)H-Index: 21
Last. Nobukazu Ishizaka (Osaka Medical College)H-Index: 34
view all 17 authors...
: IgG4-related disease is a systemic disease, characterized by elevation of serum IgG4 and, histopathologically, massive infiltration of IgG4+ lymphocyte and plasma cell infiltration, storiform fibrosis, causing enlargement, nodules or thickening. It may affect various organs simultaneously or metachronously. Here we analyzed the clinical and pathological characteristics of 99 patients diagnosed with IgG4-related periaortitis/periarteritis and retroperitoneal fibrosis. Of 99 patients (women/men,...
9 CitationsSource