In Sik Kim
Eulji University
ChemokineImmunoglobulin EMolecular biologyChemistryApoptosisImmunologyInflammationEosinophilBronchoalveolar lavageHouse dust miteCytokineMonocyteCancer researchChemotaxisMAPK/ERK pathwayMedicineBiologyCell biologyPharmacology
Publications 101
S100 calcium-binding protein A8 (S100A8), a danger-associated molecular pattern, has emerged as an important mediator of the pro-inflammatory response. Some S100 proteins play a prominent role in neuroinflammatory disorders and increase the secretion of pro-inflammatory cytokines in microglial cells. The aim of this study was to determine whether S100A8 induced neuronal apoptosis during cerebral hypoxia and elucidate its mechanism of action. In this study, we reported that the S100A8 protein exp...
#8Eun Ju Yang (Daegu Haany University)H-Index: 2
#1Min Hwa HongH-Index: 4
#2Ayesha KashifH-Index: 6
Last. In Sik KimH-Index: 17
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Background: The house dust mite (HDM) is the most common cause of allergic diseases, and TLR4 acts as an overarching receptor for allergic responses. This study aimed to identify novel allergen binding to TLR4 in HDMs and unveil its unique role in allergic responses. Methods: Der p 38 was purified and characterized by LC-MS/MS-based peptide mapping. Biolayer interferometry and structure modeling unveiled TLR4-binding activity and the structure of recombinant Der p 38. The allergenicity of Der p ...
#1Hye-Rim Choi (Konyang University)H-Index: 3
#2Ji Sun Ha (Konyang University)H-Index: 2
Last. Seung-Ju Yang (Konyang University)H-Index: 10
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알츠하이머 병은 인지 기능 저하로 인한 치매 발생으로 설명할 수 있는 만성 및 진행성 신경 퇴행성 질환이다. 알츠하이머 병의 특징은 세포 외 및 세포 내 아밀로이드 플라크의 형성이다. 아밀로이드 베타는 알츠하이머 병의 특징이며 미세아교세포는 아밀로이드 베타의 존재하에 활성화될 수 있다. 활성화된 미세아교세포는 전 염증성 사이토카인을 분비한다. 게다가, S100A9는 염증의 중요한 선천성 전 염증 기여자이며 알츠하이머 병에 잠재적인 기여자로 알려져 있다. 이 연구는 아밀로이드 베타 및 S100A9이 처리된 BV-2 세포에서 염증반응 및 NLRP3 인플라마솜 활성화에 대한 메트포르민 및 알파리포산의 효과를 조사했다. 메트포르민과 알파-리포산은 종양 괴사 인자-알파 및 일터루킨-6와 같은 염증성 사이토카인을 약화시킨다. 또한 메트포르민과 알파-리포산은 JNK, ERK, p38의 인산화를 억제하고, NF-kB 경로 및 NLRP3 인플라마솜의 활성화를 억제했다. 또한 메트포르민과 알파-리포산...
#1Ji-Sook LeeH-Index: 18
#2Na Rae LeeH-Index: 5
Last. In Sik KimH-Index: 17
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S100A8 and S100A9 function as essential factors in inflammation, and also exert anti-tumor or tumorigenic activity depending on the type of cancer. Chronic eosinophilic leukemia (CEL) is a rare hematological malignancy having elevated levels of eosinophils, and characterized by the presence of the FIP1L1-PDGFRA fusion gene. In this study, we examined the pro-apoptotic mechanisms of S100A8 and S100A9 in FIP1L1-PDGFRα+ eosinophilic cells and hypereosinophilic patient cells. S100A8 and S100A9 induc...
#1Gi Tae Kim (Eulji University)H-Index: 2
#2In Sik Kim (Eulji University)H-Index: 17
Last. Jae Woong Sull (Eulji University)H-Index: 10
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고혈압은 종종 심혈관 질환 및 신장 질환으로 이어지며 전 세계적으로 중요한 문제이다. 유전적으로 많은 단일 염기 다형성이 고혈압과 관련이 있다. 많은 GWAS 연구에서 ATP2B1 유전자가 혈압과 연관성이 높다는 것을 발견했다. 본 연구에서는 한국인 994명을 대상으로 수축기 혈압, 이완기 혈압과 ATP2B1 유전자의 SNP와 연관성을 분석하였다. 또한, BMI수치에 따라 하위그룹으로 계층화하여 차이가 있는지 확인하고자 하였다. 다중선형회귀분석에서 수축기 혈압 및 이완기 혈압과 가장 높은 통계적 유의성을 보인 SNP를 선정하였다. 수축기 혈압과 이완기 혈압에서의 one-way analysis of variance를 시행하였고, 고혈압 발생 위험에 대한 다중로지스틱회귀분석을 시행하였다. 다중로지스틱회귀분석은 연령 기준으로 구분하여 시행하였으며, 연령, BMI, 공복 시 혈당을 통제한 방법에서 비교하였다. 수축기 혈압에서는 4개의 SNP (rs10506974, rs7136259, rs1...
#1Gi Tae KimH-Index: 2
#2In Sik KimH-Index: 17
Last. Jae Woong SullH-Index: 10
view all 4 authors...
#1Da Hye Kim (Eulji University)H-Index: 5
#2Ayoung Gu (Eulji University)H-Index: 5
Last. In Sik Kim (Eulji University)H-Index: 17
view all 10 authors...
S100A8 and S100A9 are important proteins in the pathogenesis of allergy. Asthma is an allergic lung disease, characterized by bronchial inflammation due to leukocytes, bronchoconstriction, and allergen-specific IgE. In this study, we examined the role of S100A8 and S100A9 in the interaction of cytokine release from bronchial epithelial cells, with constitutive apoptosis of neutrophils. S100A8 and S100A9 induce increased secretion of neutrophil survival cytokines such as MCP-1, IL-6 and IL-8. Thi...
#1Ji Yeong Ahn (Eulji University)H-Index: 1
#2In Sik Kim (Eulji University)H-Index: 17
Last. Ji-Sook Lee (Health Science University)H-Index: 18
view all 3 authors...
#1Kyung-Jae Cha (Eulji University)H-Index: 3
#2Chang-Seob SongH-Index: 1
Last. In Sik Kim (Eulji University)H-Index: 17
view all 7 authors...
Chaenomeles sinensis Koehne (CS) has been used in a traditional oriental medicine for treating throat diseases, anaphylaxis, viral infection, and inflammation. This study investigated the underlying mechanism of anti-allergic effect of CS. Leaves of CS plants were dried, powdered, and then underwent extraction with DMSO. Both ELISA and western blotting were performed to evaluate cytokine concentration and the expression and activation of filaggrin and JNK. Five-week-old female NC/Nga mice were u...
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