Giuseppe Remuzzi
Mario Negri Institute for Pharmacological Research
Internal medicineUrologyEndocrinologySurgeryPathologyRenal functionIntensive care medicineImmunologyKidney diseaseDiseaseProteinuriaKidneyKidney transplantationNephropathyTransplantationNephrologyDiabetes mellitusMedicineBiologyGastroenterology
Publications 1,317
#1Boris Bikbov (Mario Negri Institute for Pharmacological Research)H-Index: 48
#2María José Soler (Autonomous University of Barcelona)H-Index: 29
Last. Gaye Hafez (Istanbul Kemerburgaz University)
view all 13 authors...
Kidney dysfunction can profoundly influence many organ systems, and recent evidence suggests a potential role for increased albuminuria in the development of mild cognitive impairment (MCI) or dementia. Epidemiological studies conducted in different populations have demonstrated that the presence of increased albuminuria is associated with a higher relative risk of MCI or dementia both in cross-sectional analyses and in studies with long-term follow-up. The underlying pathophysiological mechanis...
#1Muh Geot Wong (The George Institute for Global Health)H-Index: 18
#2Jicheng Lv (PKU: Peking University)H-Index: 37
Last. Vlado Perkovic (The George Institute for Global Health)H-Index: 94
view all 27 authors...
INTRODUCTION Despite optimal current care, up to 30% of individuals suffering from immunoglobulin A nephropathy (IgAN) will develop kidney failure requiring dialysis or kidney transplantation. The Therapeutic Evaluation of STeroids in IgA Nephropathy Global (TESTING) study was designed to assess the benefits and risks of steroids in people with IgAN. We report the trial design as well as the baseline characteristics of study participants. METHODS It is an investigator-initiated, multicenter, dou...
#1Carmine ZoccaliH-Index: 113
#2Alberto Ortiz (Leipzig University)
Last. Francesca MallamaciH-Index: 74
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Neuropeptide Y (NPY) is a 36-amino-acid peptide member of a family also including peptide YY and pancreatic polypeptide which are all ligands to Gi/Go coupled receptors. NPY regulates several fundamental biologic functions including appetite/satiety, sex and reproduction, learning and memory, cardiovascular and renal function and the immune function. The mesenteric circulation is a major source of NPY in the blood in man and this peptide is considered a key regulator of the gut-brain cross-talk....
#1Fabiola Carrara (Mario Negri Institute for Pharmacological Research)H-Index: 15
#2Piero Ruggenenti (Mario Negri Institute for Pharmacological Research)H-Index: 93
Last. Aneliya Parvanova (Mario Negri Institute for Pharmacological Research)H-Index: 14
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AIMS Investigating whether and to what extent changes in glomerular hemodynamic parameters, beyond glomerular hyperfiltration, could predict glomerular filtration rate (GFR) decline in hypertensive, non-proteinuric type 2 diabetic patients. MATERIALS AND METHODS We estimated baseline afferent (Ra) and efferent (Re) arteriolar resistances and glomerular hydrostatic pressure in 60 consecutive patients from DEMAND study, using the Gomez' equations. Baseline renal plasma flow was measured by para-am...
#1Marina Noris (Mario Negri Institute for Pharmacological Research)H-Index: 78
#2Erica Daina (Mario Negri Institute for Pharmacological Research)H-Index: 19
Last. Giuseppe Remuzzi (Mario Negri Institute for Pharmacological Research)H-Index: 196
view all 3 authors...
Membranoproliferative glomerulonephritis (MPGN) is a pattern of glomerular injury that may be primary or secondary to infections, autoimmune diseases and haematological disorders. Primary C3G and IC-MPGN are rare and the prognosis is unfavourable. Based on immunofluorescence findings, MPGN has been classified into complement-mediated C3 glomerulopathy (C3G), and immune complex-mediated MPGN (IC-MPGN). However, this classification leaves a number of issues unresolved. The finding of genetic and a...
#1Jorge R LedesmaH-Index: 6
#2Jianing MaH-Index: 3
Last. Hmwe H KyuH-Index: 45
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Summary null null Background null Tuberculosis is a major contributor to the global burden of disease, causing more than a million deaths annually. Given an emphasis on equity in access to diagnosis and treatment of tuberculosis in global health targets, evaluations of differences in tuberculosis burden by sex are crucial. We aimed to assess the levels and trends of the global burden of tuberculosis, with an emphasis on investigating differences in sex by HIV status for 204 countries and territo...
Summary null Background null The effects of pharmacological blood-pressure-lowering on cardiovascular outcomes in individuals aged 70 years and older, particularly when blood pressure is not substantially increased, is uncertain. We compared the effects of blood-pressure-lowering treatment on the risk of major cardiovascular events in groups of patients stratified by age and blood pressure at baseline. null Methods null We did a meta-analysis using individual participant-level data from randomis...
#1Katherine Paulson (UW: University of Washington)H-Index: 12
#2Aruna M Kamath (UW: University of Washington)H-Index: 3
Last. Sherief M Abd-ElsalamH-Index: 1
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Summary null Background null Sustainable Development Goal 3.2 has targeted elimination of preventable child mortality, reduction of neonatal death to less than 12 per 1000 livebirths, and reduction of death of children younger than 5 years to less than 25 per 1000 livebirths, for each country by 2030. To understand current rates, recent trends, and potential trajectories of child mortality for the next decade, we present the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 ...
#1Norberto Perico (Mario Negri Institute for Pharmacological Research)H-Index: 95
#2Luca Perico (Mario Negri Institute for Pharmacological Research)H-Index: 16
Last. Giuseppe Remuzzi (Mario Negri Institute for Pharmacological Research)H-Index: 196
view all 4 authors...
Clinical Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread globally from late 2019, reaching pandemic proportions. Epidemiology: The related disease, COVID-19, exacerbates and progresses due to patients' abnormal inflammatory/immune responses, widespread endothelial damage, and complement-induced blood clotting with microangiopathy. COVID-19 manifests mainly as a respiratory illness. In cases of severe viral pneumonia, it may lead to acute respirat...
#1Giuseppe Remuzzi (Mario Negri Institute for Pharmacological Research)H-Index: 196
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