Hede Yan
Wenzhou Medical College
AnatomyUrologySoft tissueSurgeryPerfusionRetrospective cohort studyPhysical therapyCohort studySurvival rateCochrane LibraryContractureNeuropathic painInclusion and exclusion criteriaNeuromaPerforator flapsFree flapAbdomenAngiogenesisElbowFlap survivalAnesthesiaNecrosisRange of motionMedicine
40Publications
9H-index
234Citations
Publications 41
Newest
#1Junling Liu (WMU: Wenzhou Medical College)H-Index: 1
#2Baoxia Chen (WMU: Wenzhou Medical College)
Last. Hede Yan (WMU: Wenzhou Medical College)H-Index: 9
view all 10 authors...
Arterialized venous flap (AVF) is limited in clinical application because its survival remains inconsistent and its exact survival mechanism is still unclear. Hirudin is an effective thrombin specific inhibitor, which is isolated from the salivary gland secretions of the leech. Our study evaluated the impact of hirudin on the viability of AVFs in rabbits. Thirty-six rabbits were randomly divided into three groups: sham group (physiological perfusion), control group (AVF), and hirudin group (AVF ...
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#1Kaizong Yuan (WMU: Wenzhou Medical College)H-Index: 2
#2Feng ZhangH-Index: 155
Last. Hede YanH-Index: 5
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BACKGROUND The purpose of this study was to compare the reconstructive outcomes of soft-tissue defects around foot and ankle with local or free flaps and attempt to provide an optimal strategy for these patients in comparison with the conventional guidelines. METHODS A retrospective review of all continuous patients with foot and ankle reconstruction using different flaps from 2010 to 2018 was performed. Based on the flap types, the patients were divided into 2 groups: local flap group and free ...
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#1Tianli Huang (WMU: Wenzhou Medical College)
#2Jialu Shi (WMU: Wenzhou Medical College)
Last. Bin Zhao (WMU: Wenzhou Medical College)H-Index: 5
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Abstract Objective The investigation and practice of physical therapy in flap surgery are still scare. The purpose of this study is to evaluate the impact of different microneedling interventions on survival of random pattern flaps in rats, attempting to determine the optimal microneedling protocols for improvement of flap survival. Methods 80 male Sprague-Dawley rats were randomly divided into 4 groups, with 20 in each group (group A, B, C and D). A 3cm × 9 cm rectangular random flap as the McF...
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#1Xiaobin Luo (WMU: Wenzhou Medical College)H-Index: 1
#2Bin Zhao (WMU: Wenzhou Medical College)H-Index: 5
Last. Hede Yan (WMU: Wenzhou Medical College)H-Index: 9
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Background The application of random pattern skin flaps is limited in plastic surgery reconstruction due to necrosis. Trans-cinnamaldehyde has antibacterial, anticancer, and antioxidant properties. In this study, we aimed to investigate the effect of trans-cinnamaldehyde on skin flap survival and its possible mechanism regarding nitric oxide. Materials and Methods One hundred forty male Sprague-Dawley rats were randomly divided into seven groups (n = 20 each group). After the dorsal flap was rai...
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#1Zeyuan Jin (WMU: Wenzhou Medical College)H-Index: 1
#2Xiaobin Luo (WMU: Wenzhou Medical College)H-Index: 1
Last. Hede Yan (WMU: Wenzhou Medical College)H-Index: 9
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BACKGROUND An arterialized venous flap (AVF) is an ideal choice of flap with which to repair wounds. However, the survival of these flaps remains the source of some concern. This study used metabolomic analysis to investigate the mechanisms underlying survival in AVF flaps in order to guide the clinical application of these flaps. METHODS Thirty-six male Japanese rabbits were randomly divided into a sham group and an AVF group. They were used for histology and hemodynamic investigations. Three d...
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#1Xiaobin Luo (WMU: Wenzhou Medical College)H-Index: 1
#2Hongyu Chen (WMU: Wenzhou Medical College)H-Index: 1
Last. Hede Yan (WMU: Wenzhou Medical College)H-Index: 9
view all 8 authors...
Background: Neuropathic pain, produced by symptomatic neuromas, is an important problem following peripheral nerve injury. Anastomosing the stump nerves end-to-end for peripheral nerve injury is a well-established but can’t avoid neuroma in-continuity forming efficiently. Methods: Seventy-two rats were randomly divided into four groups: rats with anastomosis sites supported by silicone tubes represented the internal nerve splinting (INS, n = 18) group, rats with simple anastomosis represented th...
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#1Baolong Li (WMU: Wenzhou Medical College)H-Index: 1
#1Baolong LiH-Index: 2
Last. Hede YanH-Index: 9
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Multiterritory perforator flap is an important plastic surgery technique, yet its efficacy can be limited by partial necrosis at the chokeⅡzone. Butylphthalide (NBP) has been used in many diseases, but has not been studied in the multiterritory perforator flap. With the effect of NBP, we observed increasing in capillary density, inhibition of autophagy and oxidative stress, and a reduction in apoptosis of cells, all consistent with increased flap survival. However, the protective effect of NBP o...
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#1Xiaobin Luo (WMU: Wenzhou Medical College)H-Index: 1
#2Bin Zhao (WMU: Wenzhou Medical College)H-Index: 5
Last. Hede Yan (WMU: Wenzhou Medical College)H-Index: 9
view all 7 authors...
Abstract Perforator flaps have been widely used in clinical Settings, however, unexpected necrosis was still commonly encountered in the distal portions of multiterritory flaps known as Choke zone III. In this study, we introduced a novel hybrid perfusion technique which is different from the established one of arterial supercharging or venous superdrainage to improve multiterritory flap survival with success. In order to ensure the entire flap survival of multiterritory flaps extending to choke...
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#1Tokai B Cooper (WMU: Wenzhou Medical College)H-Index: 3
#2Keshav Poonit (WMU: Wenzhou Medical College)H-Index: 4
Last. Hede Yan (WMU: Wenzhou Medical College)H-Index: 9
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Background:We intend to assess the efficacies and limitations of collagenase clostridium histolyticum (CCH) and fasciectomy in treating Dupuytren’s contracture, and the associated complications and...
2 CitationsSource
#1Xijie ZhouH-Index: 4
#2Bin ZhaoH-Index: 5
Last. Hede YanH-Index: 9
view all 7 authors...
OBJECTIVE: Traumatic neuromas represent a prevalent source of neuropathic pain. As of yet, there has been no single treatment method that can guarantee permanent relief of symptoms. Although nerve-capping techniques have shown promise, their exact mechanisms remain elusive. The authors' aim was to examine the role of the RhoA/ROCK signaling pathway in the prevention of neuroma formation after neurectomy utilizing a nerve-capping technique. METHODS: An aligned nanofiber tube was fabricated to cap...
2 CitationsSource