Paula Ludovico
University of Minho
ChemistryApoptosisImmunologyAutophagyOxidative stressAcetic acidLongevitySaccharomyces cerevisiaeParacoccidioides brasiliensisYeastMitochondrionCell cycleProgrammed cell deathReactive oxygen speciesCancer researchGeneticsBiochemistryCell growthComputational biologyMedicineBiologyMicrobiologyCell biology
96Publications
33H-index
7,872Citations
Publications 95
Newest
#1Fernanda Marques (University of Minho)H-Index: 34
#2Luísa Pinto (University of Minho)H-Index: 29
Last. Paula Ludovico (University of Minho)H-Index: 33
view all 9 authors...
Medical students tend to have difficulties in developing a holistic view of metabolic pathway and hormone regulation. To address this issue, an interactive activity was implemented for first-year medical students at the School of Medicine, University of Minho, Portugal. Students' previous knowledge on metabolic pathways was evaluated by a pre-test followed by an interactive activity. In the supervised activity, students were challenged to elaborate a diagrammatic representation regarding enzymes...
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#1Isabel CastroH-Index: 4
Last. Paula LudovicoH-Index: 33
view all 10 authors...
Acute myeloid leukemia (AML) is the most common acute leukemia, characterized by a heterogeneous genetic landscape contributing, among others, to the occurrence of metabolic reprogramming. Autophagy, a key player on metabolism, plays an essential role in AML. Here, we examined the association of three potentially functional genetic polymorphisms in the ATG10 gene, central for the autophagosome formation. We screened a multicenter cohort involving 309 AML patients and 356 healthy subjects for thr...
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#1Juan SainzH-Index: 21
Last. Asta Försti (DKFZ: German Cancer Research Center)H-Index: 3
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The role of genetic variation in autophagy-related genes in modulating autophagy and cancer is poorly understood. Here, we comprehensively investigated the association of autophagy-related variants with colorectal cancer (CRC) risk and provide new insights about the molecular mechanisms underlying the associations. After meta-analysis of the genome-wide association study (GWAS) data from four independent European cohorts (8006 CRC cases and 7070 controls), two loci, DAPK2 (p = 2.19 × 10−5) and A...
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#1Daniel J. Klionsky (UM: University of Michigan)H-Index: 140
#2Amal Kamal Abdel-Aziz (Ain Shams University)H-Index: 12
Last. Abraham Acevedo-Arozena (Hospital Universitario de Canarias)H-Index: 19
view all 2923 authors...
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, ...
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#1Caroline Struyfs (Katholieke Universiteit Leuven)H-Index: 6
#2Tanne L. Cools (Katholieke Universiteit Leuven)H-Index: 8
Last. Karin Thevissen (Katholieke Universiteit Leuven)H-Index: 55
view all 9 authors...
Abstract The plant defensin HsAFP1 is characterized by broad-spectrum antifungal activity and induces apoptosis in Candida albicans. In this study, we performed a transcriptome analysis on C. albicans cultures treated with HsAFP1 to gain further insight in the antifungal mode of action of HsAFP1. Various genes coding for cell surface proteins, like glycosylphosphatidylinositol (GPI)-anchored proteins, and proteins involved in cation homeostasis, autophagy and in cell cycle were differentially ex...
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#1Sofia Oliveira-Pinto (University of Minho)H-Index: 2
#2Olívia Pontes (University of Minho)H-Index: 3
Last. Marta Costa (University of Minho)H-Index: 11
view all 13 authors...
Abstract A selection of new chromeno[2,3-b]pyridines was prepared from chromenylacrylonitriles and N-substituted piperazines, using a novel and efficient synthetic procedure. The compounds were tested for their anticancer activity using breast cancer cell lines MCF-7, Hs578t and MDA-MB-231 and the non-neoplastic cell line MCF-10A for toxicity evaluation. In general, compounds showed higher activity towards the luminal breast cancer subtype (MCF-7), competitive with the reference compound Doxorub...
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#1Magali HumbertH-Index: 11
#2María MoránH-Index: 2
Last. Mario P. TschanH-Index: 38
view all 18 authors...
Autophagy is a highly conserved degradation mechanism that is essential for maintaining cellular homeostasis. In human disease, autophagy pathways are frequently deregulated and there is immense interest in targeting autophagy for therapeutic approaches. Accordingly, there is a need to determine autophagic activity in human tissues, an endeavor that is hampered by the fact that autophagy is characterized by the flux of substrates whereas histology informs only about amounts and localization of s...
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#1Sílvia Lemos (UTAD: University of Trás-os-Montes and Alto Douro)H-Index: 2
#2Belém Sampaio-Marques (University of Minho)H-Index: 20
Last. Paula A. Oliveira (UTAD: University of Trás-os-Montes and Alto Douro)H-Index: 25
view all 9 authors...
OBJECTIVE(S): Different types of tumors often present an overexpression of cyclooxygenase-2. The aim of this study was to evaluate the effects of parecoxib (NSAID, cyclooxygenase-2 selective inhibitor) in the behavior of the human osteosarcoma MG-63 cell line, concerning several biological features. METHODS: Cells were exposed to several concentrations of parecoxib for 48 hours. Cell viability/proliferation, cyclooxygenase-2 expression, morphologic alterations, membrane integrity, cell cycle eva...
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#1Patrícia LageH-Index: 6
#2Belém Sampaio-Marques (University of Minho)H-Index: 20
Last. Ana Mendes-FerreiraH-Index: 18
view all 5 authors...
During vinification Saccharomyces cerevisiae cells are frequently exposed to high concentrations of sulfur dioxide (SO2) that is used to avoid overgrowth of unwanted bacteria or fungi present in the must. Up to now the characterization of the molecular mechanisms by which S. cerevisiae responds and tolerates SO2 was focused on the role of the sulfite efflux pump Ssu1 and investigation on the involvement of other players has been scarce, especially at a genome-wide level. In this work, we uncover...
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#1Isabel Castro (University of Minho)H-Index: 4
#2Belém Sampaio-Marques (University of Minho)H-Index: 20
Last. Paula Ludovico (University of Minho)H-Index: 33
view all 3 authors...
The cancer metabolic reprogramming allows the maintenance of tumor proliferation, expansion and survival by altering key bioenergetics, biosynthetic and redox functions to meet the higher demands of tumor cells. In addition, several metabolites are also needed to perform signaling functions that further promote tumor growth and progression. These metabolic alterations have been exploited in different cancers, including acute myeloid leukemia, as novel therapeutic strategies both in preclinical m...
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