Fitz Roy E Curry
University of California, Davis
AnatomyVascular permeabilityPermeability (electromagnetism)Endothelial stem cellBiophysicsInternal medicineMicrocirculationEndocrinologyPerfusionChemistryCapillary actionIn vivoAlbuminMicrovesselEndotheliumGlycocalyxCalciumBiochemistryBiologyCell biology
163Publications
60H-index
6,397Citations
Publications 155
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#2Katharina SchusterH-Index: 1
Last. Mariya Y. RadevaH-Index: 11
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Epac1 (exchange protein activated by cAMP) stabilizes the endothelial barrier, but detailed studies are limited by the side effects of pharmacological Epac1 modulators and transient transfections. Here, we compare the key properties of barriers between endothelial cells derived from wild-type (WT) and Epac1-knockout (KO) mice myocardium. We found that KO cell layers, unlike WT layers, had low and cAMP-insensitive trans-endothelial resistance (TER). They also had fragmented VE-cadherin staining d...
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#1C. Charles Michel (Imperial College London)H-Index: 18
#2Tom WoodcockH-Index: 12
Last. Fitz Roy E Curry (UC Davis: University of California, Davis)H-Index: 60
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The Starling Principle states that fluid movements between blood and tissues are determined by differences in hydrostatic and colloid osmotic (oncotic) pressures between plasma inside microvessels and fluid outside them. The Revised Starling Principle recognizes that, because microvessels are permeable to macromolecules, a balance of pressures cannot halt fluid exchange. In most tissues, steady oncotic pressure differences between plasma and interstitial fluid depend on low levels of steady filt...
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#1Kathrine Sivertsen Åsrud (University of Bergen)H-Index: 4
#2Ronja Bjørnstad (University of Bergen)H-Index: 5
Last. Stein Ove Døskeland (University of Bergen)H-Index: 65
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AIM: The cAMP-mediator Epac1 (RapGef3) has high renal expression. Preliminary observations revealed increased diuresis in Epac1(-/-) mice. We hypothesized that Epac1 could restrict diuresis by promoting transcellular collecting duct (CD) water and urea transport or by stabilizing CD paracellular junctions to reduce osmolyte loss from the renal papillary interstitium. METHODS: In Epac1(-/-) and Wt C57BL/6J mice, renal papillae, dissected from snap-frozen kidneys, were assayed for the content of k...
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#1Fitz Roy E Curry (UC Davis: University of California, Davis)H-Index: 60
#2Torfinn Taxt (University of Bergen)H-Index: 29
Last. Rolf K. Reed (University of Bergen)H-Index: 68
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Author(s): Curry, Fitz-Roy E; Taxt, Torfinn; Rygh, Cecilie Brekke; Pavlin, Tina; Bjonrstad, Ronja; Doskeland, Stein Ove; Reed, Rolf K | Abstract: AIM:Epac1-/- mice, but not Epac2-/- mice have elevated baseline permeability to albumin. This study extends the investigations of how Epac-dependent pathways modulate transvascular exchange in response to the classical inflammatory agent histamine. It also evaluates the limitations of models of blood-to-tissue exchange in transgenic mice in DCE-MRI mea...
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#1Fitz Roy E Curry (UC Davis: University of California, Davis)H-Index: 60
#2C. Charles Michel (Imperial College London)H-Index: 18
BACKGROUND: Ultrastructural investigations of the endothelial glycocalyx reveal a layer adjacent to the cell surface with a structure consistent with the primary ultrafilter of vascular walls. Theory predicts this layer can be no greater than 200-300 nm thick, a result to be reconciled with observations that red cells and large macromolecules are excluded from a region 1 micrometer or more from the cell membrane. OBJECTIVE: To determine whether this apparent inconsistency might be accounted for ...
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#1Fitz Roy E Curry (UC Davis: University of California, Davis)H-Index: 60
There has been rapid progress over the past decade to extend the concept that a quasiperiodic inner endothelial glycocalyx layer (EGL, <300 nm thick, with key components associated with the endothelial cell membrane) forms the primary molecular filter between circulating blood and the body tissues. The EGL is common to both continuous and fenestrated microvessels. The revised Starling Principle describing steady-state fluid exchange across the EGL describes new ways to understand transvascular e...
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#1Brett Z. Fite (UC Davis: University of California, Davis)H-Index: 15
#2Azadeh Kheirolomoom (UC Davis: University of California, Davis)H-Index: 26
Last. Katherine W. Ferrara (UC Davis: University of California, Davis)H-Index: 73
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Abstract Temperature-sensitive liposomal formulations of chemotherapeutics, such as doxorubicin, can achieve locally high drug concentrations within a tumor and tumor vasculature while maintaining low systemic toxicity. Further, doxorubicin delivery by temperature-sensitive liposomes can reliably cure local cancer in mouse models. Histological sections of treated tumors have detected red blood cell extravasation within tumors treated with temperature-sensitive doxorubicin and ultrasound hyperthe...
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#1Fitz Roy E Curry (UC Davis: University of California, Davis)H-Index: 60
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