Filippo Piatti
Polytechnic University of Milan
Internal medicineBiomedical engineeringMagnetic resonance imagingBlood flowCardiologySystoleHemodynamicsMaterials scienceShear stressThoracic aortaAscending aortaAortaAortic valveBicuspid aortic valveAortic flowFlow (mathematics)Computer scienceDiastoleMedicineFluid dynamics
Publications 30
#1Kristina Haase (MIT: Massachusetts Institute of Technology)H-Index: 13
#2Filippo Piatti (Polytechnic University of Milan)H-Index: 7
Last. Roger D. Kamm (MIT: Massachusetts Institute of Technology)H-Index: 108
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Hemodynamics play a central role in the health and disease of the coronary and peripheral vascular systems. Vessel-lining endothelial cells are known mechanosensors, responding to disturbances in flow - with mechanosensitivity hypothesized to change in response to metabolic demands. The health of our smallest microvessels have been lauded as a prognostic marker for cardiovascular health. Yet, despite numerous animal models, studying these small vessels has proved difficult. Microfluidic technolo...
#2Hector I. Michelena (Mayo Clinic)H-Index: 47
Last. Amalia ForteH-Index: 15
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Abstract The current management of aortic dilatation associated with congenital bicuspid aortic valve (BAV aortopathy) is based on dimensional parameters (diameter of the aneurysm, growth of the diameter over time) and few other criteria. The disease is however heterogeneous in terms of natural and clinical history and risk of acute complications, i.e. aortic dissection. Dimensional criteria are now admitted to have limited value as predictors of such complications. Thus, novel principles for ri...
15 CitationsSource
#1Monica Emendi (SBU: Stony Brook University)H-Index: 1
#2Francesco SturlaH-Index: 11
Last. Danny Bluestein (SBU: Stony Brook University)H-Index: 41
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Congenital bicuspid aortic valve (BAV) consists of two fused cusps and represents a major risk factor for calcific valvular stenosis. Herein, a fully coupled fluid-structure interaction (FSI) BAV model was developed from patient-specific magnetic resonance imaging (MRI) and compared against in vivo 4-dimensional flow MRI (4D Flow). FSI simulation compared well with 4D Flow, confirming direction and magnitude of the flow jet impinging onto the aortic wall as well as location and extension of seco...
6 CitationsSource
#1Francesco SturlaH-Index: 11
#2Filippo PiattiH-Index: 7
Last. Massimo LombardiH-Index: 61
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Abstract Purpose We exploited 4-dimensional flow magnetic resonance imaging (4D Flow), combined with a standardized in vitro setting, to establish a comprehensive benchmark for the systematic hemodynamic comparison of surgical aortic bioprosthetic valves (BPVs). Materials and methods 4D Flow analysis was performed on two small sizes of three commercialized pericardial BPVs (Trifecta™ GT, Carpentier-Edwards PERIMOUNT Magna and Crown PRT®). Each BPV was tested over a clinically pertinent range of ...
#1Simone Saitta (Imperial College London)H-Index: 3
#2Selene Pirola (Imperial College London)H-Index: 7
Last. Alberto Redaelli (Polytechnic University of Milan)H-Index: 49
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Abstract Severity of aortic coarctation (CoA) is currently assessed by estimating trans-coarctation pressure drops through cardiac catheterization or echocardiography. In principle, more detailed information could be obtained non-invasively based on space- and time-resolved magnetic resonance imaging (4D flow) data. Yet the limitations of this imaging technique require testing the accuracy of 4D flow-derived hemodynamic quantities against other methodologies. With the objective of assessing the ...
13 CitationsSource
#1Silvia PicaH-Index: 12
#2Filippo PiattiH-Index: 7
Last. Massimo LombardiH-Index: 61
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#1Igor Nesteruk (Kyiv Polytechnic Institute)H-Index: 11
#2Filippo PiattiH-Index: 7
Last. Alberto Redaelli (Polytechnic University of Milan)H-Index: 49
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Magnetic resonance imaging (MRI) using three-dimensional velocity encoding phase contrast methods offers the opportunity to quantify time-resolved 3D flow patterns in vivo. This technique can have a breakthrough impact on the evaluation, risk stratification and surgical planning in hemodynamic-related pathologies, e.g., cardiac valve diseases, arterial stenos or insufficiency, dilation, dissection or coartaction. Nevertheless, the limited time and space resolution of 4D MRI data restricts the ac...
1 CitationsSource
#1Mario Gaudino (Cornell University)H-Index: 39
#2Filippo Piatti (Polytechnic University of Milan)H-Index: 7
Last. Ruggero De PaulisH-Index: 29
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Abstract Objectives This study applied advanced 4-dimensional flow magnetic resonance imaging processing to assess differences in aortic flow dynamics after valve sparing root replacement, with and without reconstruction of the Valsalva sinuses. Methods We enrolled patients after valve sparing root replacement with a straight tubular prosthesis (n = 10) or with a prosthesis with Valsalva neosinuses (n = 10); age-matched subjects without cardiovascular diseases served as controls (n = 10). 4-Dime...
23 CitationsSource
#1Filippo PiattiH-Index: 7
#2Antonia CamporealeH-Index: 7
Last. Massimo LombardiH-Index: 61
view all 11 authors...