Eleanor Evans
University of Cambridge
Imaging phantomBolus (medicine)Temporal resolutionPhysicsCorrection for attenuationBiomedical engineeringIterative reconstructionMagnetic resonance imagingAttenuation coefficientAttenuationMaterials scienceMedical physicsStandardized uptake valueImage resolutionRadiofrequency coilPositron emission tomographyTRACERVentricleImage (category theory)Flip angleMouse HeartArterial input functionPartial volume correctionBlood samplingNuclear medicineDirect evaluationRat brainBody regionMr imagesPet tracerGold standard (test)Nuclear magnetic resonanceVoxelPoint spread functionMedicinePartial volumeReproducibility
6Publications
2H-index
10Citations
Publications 5
Newest
#1Eleanor Evans (University of Cambridge)H-Index: 2
#2Guido Buonincontri (University of Cambridge)H-Index: 14
Last. Stephen J. Sawiak (University of Cambridge)H-Index: 26
view all 6 authors...
Attenuation correction (AC) must be applied to provide accurate measurements of PET tracer activity concentrations. Due to the limited space available in PET/MR scanners, MR-derived AC (MRAC) is used as a substitute for transmission source scanning. In preclinical PET/MR, there has been limited exploration of MRAC, as the magnitude of AC in murine imaging is much smaller than that required in clinical scans. We investigated if a simple 2 class (air and tissue) segmentation-based MRAC approach co...
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#1Eleanor Evans (University of Cambridge)H-Index: 2
#2Guido Buonincontri (University of Cambridge)H-Index: 14
Last. Stephen J. Sawiak (University of Cambridge)H-Index: 26
view all 9 authors...
Accurate kinetic modelling using dynamic PET requires knowledge of the tracer concentration in plasma, known as the arterial input function (AIF). AIFs are usually determined by invasive blood sampling, but this is prohibitive in murine studies due to low total blood volumes. As a result of the low spatial resolution of PET, image-derived input functions (IDIFs) must be extracted from left ventricular blood pool (LVBP) ROIs of the mouse heart. This is challenging because of partial volume and sp...
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#1Eleanor Evans (University of Cambridge)H-Index: 2
#2Guido Buonincontri (University of Cambridge)H-Index: 14
Last. Stephen J. Sawiak (University of Cambridge)H-Index: 26
view all 9 authors...
Kinetic modelling in PET requires the arterial input function (AIF), defined as the time-activity curve (TAC) in plasma. This measure is challenging to obtain in mice due to low blood volumes, resulting in a reliance on image-based methods for AIF derivation. We present a comparison of PET- and MR-based region-of-interest (ROI) analysis to obtain image-derived AIFs from the left ventricle (LV) of a mouse model. ROI-based partial volume correction (PVC) was performed to improve quantification. MR...
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#1Eleanor Evans (University of Cambridge)H-Index: 2
#2Stephen J. Sawiak (University of Cambridge)H-Index: 26
Last. T. Adrian Carpenter (University of Cambridge)H-Index: 46
view all 6 authors...
Accurate kinetic modelling of in vivo physiological function using positron emission tomography (PET) requires determination of the tracer time–activity curve in plasma, known as the arterial input function (AIF). The AIF is usually determined by invasive blood sampling methods, which are prohibitive in murine studies due to low total blood volumes. Extracting AIFs from PET images is also challenging due to large partial volume effects (PVE). We hypothesise that in combined PET with magnetic res...
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#1Eleanor Evans (University of Cambridge)H-Index: 2
#2Stephen J. Sawiak (University of Cambridge)H-Index: 26
Last. T. Adrian Carpenter (University of Cambridge)H-Index: 46
view all 3 authors...
Abstract Simultaneous PET–MR acquisition provides the high temporal and spatial resolution of MRI with the specificity of PET. In PET, accurate modelling of physiological function in vivo requires the time-activity curve of tracer in blood plasma, known as the arterial input function (AIF). As the gold standard method of blood sampling is inherently prohibitive in the small animal case, here we discuss how we prepare to rapidly sample MRI signals from gadolinium-doped tracer to obtain the tracer...
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