Alexandra L. Whittaker
University of Adelaide
WelfareInternal medicineEndocrinologyDevelopmental psychologySurgerySocial statusPsychologyCognitionPolitical scienceIntensive care medicinePersonalityCognitive biasJudgementChemotherapyAnimal Welfare (journal)LegislationSalinePain assessmentSpace (commercial competition)MucositisTest (assessment)Quality (business)EnforcementLaw enforcementAnimal lawChemotherapy inducedAnesthesiaReliability (statistics)Animal welfareAnimal husbandryMedicineLegislatureBiologyGastroenterology
54Publications
11H-index
328Citations
Publications 52
Newest
#1Rebecca P. George (University of Adelaide)H-Index: 2
#2Ines Semendric (University of Adelaide)H-Index: 1
Last. Alexandra L. Whittaker (University of Adelaide)H-Index: 11
view all 6 authors...
Patients diagnosed with cancer are often plagued with debilitating side effects post-chemotherapy treatment. One such side effect is chemotherapy-induced cognitive impairment or 'chemobrain'. Rodent models are commonly used to investigate pathogenesis and potential therapeutic strategies. However, concerns have been raised regarding inadequacies in reporting of animal studies rendering them unreliable and irreproducible. The aim of this systematic review was to assess compliance with the ARRIVE ...
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#1Clifford WarwickH-Index: 11
#2Rachel Grant (LSBU: London South Bank University)H-Index: 1
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Snakes are sentient animals and should be subject to the accepted general welfare principles of other species. However, they are also the only vertebrates commonly housed in conditions that prevent them from adopting rectilinear behavior (ability to fully stretch out). To assess the evidence bases for historical and current guidance on snake spatial considerations, we conducted a literature search and review regarding recommendations consistent with or specifying ≥1 × and <1 × snake length enclo...
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#1Daniel Mota-RojasH-Index: 22
#2Fabio NapolitanoH-Index: 31
Last. Alexandra L. WhittakerH-Index: 11
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We pose, based on a neurobiological examination, that events that occur around the time of slaughter have the potential to intensify the pain response, through the processes of sensitisation and enhanced transmission. Sensitisation, or an enhanced response to painful stimuli, is a well-discussed phenomenon in the human medical literature, which can arise from previous injury to an area, inflammatory reactions, or previous overstimulation of the stress axes. A number of events that occur prior to...
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Last. Timothy Hugh BarkerH-Index: 7
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The Mouse Grimace Scale (MGS) was developed 10 years ago as a method for assessing pain through the characterisation of changes in five facial features or action units. The strength of the technique is that it is proposed to be a measure of spontaneous or non-evoked pain. The time is opportune to map all of the research into the MGS, with a particular focus on the methods used and the technique’s utility across a range of mouse models. A comprehensive scoping review of the academic literature wa...
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#1Rebecca P. George (University of Adelaide)H-Index: 2
#2Ines Semendric (University of Adelaide)H-Index: 1
Last. Alexandra L. Whittaker (University of Adelaide)H-Index: 11
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Abstract Background Chemotherapy-induced cognitive impairment (CICI) is a debilitating side effect arising from chemotherapy treatments. The condition is characterised by a range of cognitive deficits including impairment to memory, attention, and concentration. Whilst the underlying mechanisms that contribute to CICI remain unclear, neuroinflammation has been suggested as one key contributor. Method A comprehensive systematic search of EMBASE and Medline via PubMed was conducted to identify stu...
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#1Rochelle Morton (University of Adelaide)H-Index: 2
#2Michelle L. Hebart (University of Adelaide)H-Index: 14
Last. Alexandra L. Whittaker (University of Adelaide)H-Index: 11
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Animal welfare is not included in the Australian Constitution, rendering it a residual power of the states and territories. Commentators have suggested that inconsistencies exist between the state and territory statutes, and that a uniform approach would be beneficial. However, there has been no comprehensive assessment of the nature or extent of these purported inconsistencies. This review addresses this gap by providing a state-by-state comparison of animal protection statutes based on key pro...
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Last. Timothy Hugh BarkerH-Index: 7
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#1Alexandra L. Whittaker (University of Adelaide)H-Index: 11
#2Timothy Hugh Barker (University of Adelaide)H-Index: 7
Abstract The assessment of positive emotional states in animals has been advanced considerably through the use of judgement bias testing. JBT methods have now been reported in a range of species. Generally, these tests show good validity as ascertained through use of corroborating methods of affective state determination. However, published reports of judgement bias task findings can be counter-intuitive and show high inter-individual variability. It is proposed that these outcomes may arise as ...
1 CitationsSource
Animals' facial expressions are widely used as a readout for emotion. Scientific interest in the facial expressions of laboratory animals has centered primarily on negative experiences, such as pain, experienced as a result of scientific research procedures. Recent attempts to standardize evaluation of facial expressions associated with pain in laboratory animals has culminated in the development of "grimace scales". The prevention or relief of pain in laboratory animals is a fundamental require...
3 CitationsSource
#1Daniel Mota-RojasH-Index: 22
Last. Alexandra L. WhittakerH-Index: 11
view all 6 authors...
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