Ru-Hua Tian
Guangzhou University of Chinese Medicine
PhosphorylationCancerEndocrinologyLipogenesis3T3-L1Cell signalingGlucose transporterK562 cellsHigh-performance liquid chromatographyIn vivoAdipocyteChemosensitizerPaclitaxelHeLaInsulin resistanceCajanusFlavonoidToxicityPI3K/AKT/mTOR pathwayPharmacology
Publications 3
#1Rong Tang (Guangzhou University of Chinese Medicine)H-Index: 3
#2Ru-Hua Tian (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Ying-Jie Hu (Guangzhou University of Chinese Medicine)H-Index: 6
view all 6 authors...
AbstractContext: The leaves of Cajanus cajan (L.) Millsp. (Fabaceae) have diverse bioactivities, but little safety data are reported.Objective: This study examines the toxicological profiles of C. cajan leaf extracts.Materials and methods: The leaves were extracted by water or 90% ethanol to obtain water or ethanol extract (WEC or EEC). EEC was suspended in water and successively fractionated into dichloroform and n-butanol extracts (DEC and BEC). Marker compounds of the extracts were monitored ...
6 CitationsSource
#1Ji-Huan Qin (Guangzhou University of Chinese Medicine)H-Index: 2
#2Jun-Zeng Ma (CAS: Chinese Academy of Sciences)H-Index: 7
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
view all 10 authors...
a-Hydroxylup-20(29)-en-3-on-28-oic acid (1), a natural triterpenoid, was found to possess the ability in a dose-dependent manner inhibiting hormone-induced adipocyte differentiation in 3T3-L1 preadipocytes, and restoring glucose consuming ability in dexamethasone (DXM)-induced insulin resistant 3T3-L1 adipocytes. Compound 1 was also found to ameliorate DXM-induced adipocyte dysfunction in lipolysis and adipokine secretion. Mechanistic studies revealed that 1 inhibited adipocyte differentiation i...
8 CitationsSource
#1Rui-Jing ZhuH-Index: 1
#2Xiao-Ling ShenH-Index: 7
Last. Ying-Jie Hu (Guangzhou University of Chinese Medicine)H-Index: 3
view all 7 authors...
Marsdeniae tenacissimae Caulis (MTC) is a Chinese herbal medicine used mainly for treatment of cancer, whose pharmacologically active constituents responsible for its in vivo activity and clinical efficacy have not been clearly elucidated. In this study, total aglycones of MTC (ETA) showed the ability to sensitize KB-3-1, HeLa, HepG2 and K562 cells to paclitaxel treatment. More inspiringly, ETA markedly enhanced the antitumor activity of paclitaxel in nude mice bearing HeLa or KB-3-1 xenografts....
14 CitationsSource
Close Researchers