Stephen Kennedy
John Radcliffe Hospital
Internal medicineObstetricsEndocrinologyGenotypeSurgeryPhysical therapyPediatricsGestational ageDiseasePregnancyEndometriosisPelvic painPopulationGynecologyAllele frequencyGestationGeneticsMedicineBiology
Publications 358
BackgroundParental involvement is a critical pillar in the provision of quality care for preterms, especially given their increased risk of compromised neurodevelopment.1 However, parental opinions, experiences and preferences regarding neurodevelopmental follow-up of preterms have hardly been studied or considered in healthcare planning.ObjectivesTo understand what parents know about neurodevelopmental outcomes for children born preterm.To describe parents’ experiences, satisfaction and recomme...
#10Abdullah Al Mahmud (International Centre for Diarrhoeal Disease Research, Bangladesh)H-Index: 13
Background null Selenium (Se), an essential trace mineral, has been implicated in preterm birth (PTB). We aimed to determine the association of maternal Se concentrations during pregnancy with PTB risk and gestational duration in a large number of samples collected from diverse populations. null Methods null Gestational duration data and maternal plasma or serum samples of 9946 singleton live births were obtained from 17 geographically diverse study cohorts. Maternal Se concentrations were deter...
1 CitationsSource
#1Thomas Tapmeier (John Radcliffe Hospital)H-Index: 1
#2Nilufer Rahmioglu (University of Oxford)H-Index: 21
Last. Ronald A. Harris (BCM: Baylor College of Medicine)H-Index: 6
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Endometriosis is a common chronic inflammatory condition causing pelvic pain and infertility in women, with limited treatment options and 50% heritability. We leveraged genetic analyses in two species with spontaneous endometriosis, humans and the rhesus macaque, to uncover treatment targets. We sequenced DNA from 32 human families contributing to a genetic linkage signal on chromosome 7p13-15 and observed significant overrepresentation of predicted deleterious low-frequency coding variants in N...
2 CitationsSource
#1Elizabeth M Curtis (University of Southampton)H-Index: 19
#2Camille Parsons (University of Southampton)H-Index: 11
Last. Aris T. Papageorghiou (John Radcliffe Hospital)H-Index: 76
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Background null The pattern of change in maternal bone turnover throughout pregnancy is poorly characterized. null Objective null We investigated changes across pregnancy in a marker of maternal bone resorption, urinary C-terminal telopeptide of type I collagen (CTX), the influence of gestational vitamin D supplementation, and associations between CTX and maternal postnatal bone indices. null Design null The Maternal Vitamin D Osteoporosis Study (MAVIDOS) is a randomized, double-blind, placebo-c...
#1José Villar (Green Templeton College)H-Index: 68
#2María C. Restrepo-Méndez (Green Templeton College)H-Index: 1
Last. Stephen Kennedy (Green Templeton College)H-Index: 82
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It is unclear whether prior endemic coronavirus infections affect COVID-19 severity. Here, we show that in cases of fatal COVID-19, antibody responses to the SARS-COV-2 spike are directed against epitopes shared with endemic beta-coronaviruses in the S2 subunit of the SARS-CoV-2 spike protein. This immune response is associated with the compromised production of a de novo SARS-CoV-2 spike response among individuals with fatal COVID-19 outcomes. Funding: This work was supported by the Georg and E...
#1Stephen Kennedy (University of Oxford)H-Index: 82
#1Josephine Agyeman-Duah (University of Oxford)H-Index: 1
#2Stephen Kennedy (University of Oxford)H-Index: 82
Last. Giancarlo Natalucci (UZH: University of Zurich)H-Index: 12
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Introduction: Prematurity (birth before 37 +0 weeks’ gestation) is associated with wide-ranging neurodevelopmental impairment. Prognosis among moderate to late (32 +0 to <37 +0 weeks’ gestation) preterm infants (MLPT) is better compared to their counterparts born very preterm (<32 +0 weeks’ gestation). However the risk of developmental impairment among MLPT, who make up about 84% of all preterm infants, is 2-3 times higher when compared to infants born at term. Early interventions have aimed to ...