Daisuke Takahashi
Hokkaido University
Internal medicineChemokineSurgeryMagnetic resonance imagingRetrospective cohort studyBone remodelingChemistryRheumatologyImmunologyDysplasiaOsteoclastOsteoarthritisDenosumabOsteotomyOsteoporosisThymidine phosphorylaseBone mineralArthritisRheumatoid arthritisAnkleFemoral headDeformityCartilagePathogenesisOsteolysisOrthodonticsNuclear medicineVarus osteotomyRadiographyCancer researchBone resorptionOrthopedic surgeryMedicineAcetabulumCell biology
45Publications
11H-index
343Citations
Publications 47
Newest
#1Shunichi Yokota (Hokkaido University)H-Index: 1
#2Gen Matsumae (Hokkaido University)H-Index: 2
Last. Masahiko Takahata (Hokkaido University)H-Index: 30
view all 13 authors...
Abstract null null A growing body of evidence suggests that immune factors that regulate osteoclast differentiation and bone resorption might be promising therapeutic agents for the treatment of osteoporosis. The expression of CLCF1, an immune cell-derived molecule, has been reported to be reduced in patients with postmenopausal osteoporosis. This suggests that it may be involved in bone remodeling. Thus, we explored the functional role of CLCF1 in osteoclastogenesis and bone loss associated wit...
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#1Takuya Ogawa (Hokkaido University)
#2Tomohiro Shimizu (Hokkaido University)H-Index: 11
Last. Daisuke Takahashi (Hokkaido University)H-Index: 11
view all 5 authors...
Abstract null null Background null While various predictors of treatment outcome of Pavlik harness have been reported, appropriate indications for treatment and relationships between patient characteristics and outcome are unclear. The present study aimed to identify radiological predictors for successful Pavlik harness treatment of DDH at the initiation of treatment and investigate the progression of radiological characteristics after successful treatment. null null null Methods null One-hundre...
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#1Gen Matsumae (Hokkaido University)H-Index: 2
#2Tomohiro Shimizu (Hokkaido University)H-Index: 11
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
view all 10 authors...
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#1Taku EbataH-Index: 2
Last. Norimasa IwasakiH-Index: 45
view all 13 authors...
Summary null Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA. In this study, we analyzed the molecular response of chondrocytes under condition of this type of stimulation to identify a molecular therapeutic target. Stimulated macrophages promoted hypertrophic changes in chondrocytes resulting in production of matrix-degrading enzymes of cartilage. Among the t...
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#1Gen MatsumaeH-Index: 2
#2Tomohiro ShimizuH-Index: 11
Last. Norimasa IwasakiH-Index: 45
view all 10 authors...
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#1Tomohiro Shimizu (Hokkaido University)H-Index: 11
#2Kosuke Arita (Hokkaido University)
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
view all 10 authors...
Purpose We aimed to investigate the longitudinal changes in bone metabolic markers and bone mineral density (BMD) after starting or switching from bisphosphonate (BP) to romosozumab (ROMO) or denosumab (DENO) therapies over 12 months and to determine predictors that establish associations with changes in BMD among the patients received the ROMO therapy. Methods Postmenopausal osteoporosis patients with a high risk of fracture-154 in total-were recruited; their therapies were switched to ROMO or ...
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#1Yumejiro Nakamura (Hokkaido University)H-Index: 1
#2Tomohiro Shimizu (Hokkaido University)H-Index: 11
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
view all 8 authors...
Introduction We aimed to compare the efficacy after switching from either bisphosphonates (BPs) or non-BPs (NBPs) to combination therapies of denosumab (DMAb) or zoledronic acid (Zol) with eldecalcitol (ELD) in bone mineral density (BMD) and bone metabolism and investigate the prognostic and risk factors of side effects of this therapy. Materials and methods One-hundred forty-eight patients with postmenopausal osteoporosis were recruited; their therapy was switched from BPs or NBPs to Zol or DMA...
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#1Gen Matsumae (Hokkaido University)H-Index: 2
#2Tomohiro Shimizu (Hokkaido University)H-Index: 11
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
view all 10 authors...
Background: Macrophage-derived factors are generally thought to play a key role in the pathogenesis of aseptic loosening though initiating periprosthetic inflammation and pathological bone resorption. Therefore, the aim of this study was to identify macrophage-derived factors that promote osteoclast differentiation and periprosthetic bone destruction. Methods: We examined the effects of 12 macrophage-derived factors that were identified by RNA sequencing analysis of stimulated macrophages on ost...
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#1Daisuke Takahashi (Hokkaido University)H-Index: 11
#2Yoshihiro NoyamaH-Index: 1
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
view all 7 authors...
BACKGROUND Internal fixation is recommended for treating Vancouver B1 periprosthetic femoral fractures. Although several fixation procedures have been developed with high fixation stability and union rates, long-term weight-bearing constructs are still lacking. Therefore, the aim of the present study was to evaluate the stability of a double-plate procedure using reversed contralateral locking compression-distal femoral plates for fixation of Vancouver B1 periprosthetic femoral fractures under f...
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BACKGROUND This study aimed to investigate the ability of whole-body bone scintigraphy (WB-BS) in the detection of multifocal osteonecrosis (ON) compared to whole-body magnetic resonance imaging (WB-MRI) and to clarify the characteristics of patients with multifocal ON among those with ON of the femoral head (ONFH) using WB-MRI. METHODS Forty-six patients who had symptomatic ONFH and underwent surgery in our hospital from April 2019 to October 2020 were included in the study. Data on patient dem...
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