Cecilia Marini
National Research Council
CancerInternal medicineRadiologyEndocrinologyPerfusionEndoplasmic reticulumBlood flowCardiologyCarbohydrate metabolismHemodynamicsChemistryIn vivoPositron emission tomographyDipyridamoleCoronary artery diseaseSkeletal muscleMetforminAngioplastyNuclear medicineIn patientMyocardial infarctionCancer researchIschemiaMedicineBiologyCancer cell
122Publications
28H-index
2,980Citations
Publications 117
Newest
#1Cecilia MariniH-Index: 28
#2Vanessa Cossu (UniGe: University of Genoa)H-Index: 7
Last. Carola Torazza (UniGe: University of Genoa)H-Index: 3
view all 21 authors...
Recent studies reported that the uptake of [18F]-fluorodeoxyglucose (FDG) is increased in the spinal cord (SC) and decreased in the motor cortex (MC) of patients with ALS, suggesting that the disease might differently affect the two nervous districts with different time sequence or with different mechanisms. Here we show that MC and SC astrocytes harvested from newborn B6SJL-Tg (SOD1G93A) 1Gur mice could play different roles in the pathogenesis of the disease. Spectrophotometric and cytofluorime...
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#1Cecilia MariniH-Index: 28
#2Matteo BaucknehtH-Index: 15
Last. Silvia MorbelliH-Index: 33
view all 14 authors...
Genome sharing between cancer and normal tissues might imply a similar susceptibility to chemotherapy toxicity. The present study aimed to investigate whether curative potential of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) is predicted by the metabolic response of normal tissues in patients with Hodgkin lymphoma (HL). METHODS: According to current guidelines, 86 patients with advanced-stage (IIB-IVB) HL, prospectively enrolled in the HD0607 trial (NCT00795613), underwent 18 F-f...
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#1Matteo BaucknehtH-Index: 15
#2Carlo Genova (UniGe: University of Genoa)H-Index: 22
Last. Silvia Chiola (UniGe: University of Genoa)
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An emerging clinical need is represented by identifying reliable biomarkers able to discriminate between responders and non-responders among patients showing imaging progression during the administration of immune checkpoints inhibitors for advanced non-small cell lung cancer (NSCLC). In the present study, we analyzed the prognostic power of peripheral-blood systemic inflammation indexes and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in this clinical set...
1 CitationsSource
#1Sara Sommariva (UniGe: University of Genoa)H-Index: 3
#2Mara Scussolini (UniGe: University of Genoa)H-Index: 4
Last. Michele Piana (UniGe: University of Genoa)H-Index: 30
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A recent result obtained by means of an in vitro experiment with cancer cultured cells has configured the endoplasmic reticulum as the preferential site for the accumulation of 2-deoxy-2-[18F]fluoro-D-glucose (FDG). Such a result is coherent with cell biochemistry and is made more significant by the fact that the reticular accumulation rate of FDG is dependent upon extracellular glucose availability. The objective of the present paper is to confirm in vivo the result obtained in vitro concerning...
1 CitationsSource
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#1Gianmario SambucetiH-Index: 48
#2Vanessa Cossu (UniGe: University of Genoa)H-Index: 7
Last. Cecilia MariniH-Index: 28
view all 9 authors...
3 CitationsSource
#1Matteo BaucknehtH-Index: 15
#2Stefano RaffaH-Index: 4
Last. Davide OrlandiH-Index: 17
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Musculoskeletal (MSK) pathologies are one of the leading causes of disability worldwide. However, treatment options and understanding of pathogenetic processes are still partially unclear, mainly due to a limited ability in early disease detection and response to therapy assessment. In this scenario, thanks to a strong technological advancement, structural imaging is currently established as the gold-standard of diagnosis in many MSK disorders but each single diagnostic modality (plain films, hi...
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#2Alberto MiceliH-Index: 4
Last. Silvia MorbelliH-Index: 33
view all 14 authors...
We aimed to evaluate the brain hypometabolic signature of persistent isolated olfactory dysfunction after SARS-CoV-2 infection. Twenty-two patients underwent whole-body [18F]-FDG PET, including a dedicated brain acquisition at our institution between May and December 2020 following their recovery after SARS-Cov2 infection. Fourteen of these patients presented isolated persistent hyposmia (smell diskettes olfaction test was used). A voxel-wise analysis (using Statistical Parametric Mapping softwa...
3 CitationsSource
#1Alberto MiceliH-Index: 4
#2Stefano RaffaH-Index: 4
Last. Matteo BaucknehtH-Index: 15
view all 8 authors...
Sarcoidosis is a systemic inflammatory disease of unknown etiology, pathologically characterized by non-caseating granulomas involving several organs and tissues. This pathological process can eventually affect the heart during his course leading to fibrosis associated with systolic dysfunction, conduction disturbance, and even sudden cardiac death. Due to this prognostic impact, diagnosis is crucial to optimize clinical management. The low sensitivity of endomyocardial biopsy and its invasive n...
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#1Vanessa CossuH-Index: 7
#2Marcella Bonanomi (University of Milano-Bicocca)
Last. Cecilia MariniH-Index: 28
view all 13 authors...
The relevant role of pentose phosphate pathway (PPP) in cancer metabolic reprogramming has been usually outlined by studying glucose-6-phosphate dehydrogenase (G6PD). However, recent evidence suggests an unexpected role for a less characterized PPP, triggered by hexose-6-phosphate dehydrogenase (H6PD) within the endoplasmic reticulum (ER). Studying H6PD biological role in breast and lung cancer, here we show that gene silencing of this reticular enzyme decreases cell content of PPP intermediates...
7 CitationsSource