D Giannini
University of Pisa
AirwayInternal medicineImmunologyAllergyPlaceboAsthmaRespiratory diseaseBronchial hyperresponsivenessSputumSalmeterolInhalationEosinophilAllergenBronchoconstrictionBronchodilatorMethacholineHypertonic salineAnesthesiaMedicinePulmonary function testingEosinophil cationic proteinGastroenterology
43Publications
22H-index
1,075Citations
Publications 43
Newest
#1Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
#2D GianniniH-Index: 22
Last. M. Zingoni (UniPi: University of Pisa)H-Index: 5
view all 8 authors...
Abstract In order to assess whether the administration of salmeterol/fluticasone propionate combination (50/250 mcg by Diskus) for 1 week induces tolerance to the bronchoprotective effect of salmeterol on allergen challenge, a single-blind, cross-over study was carried out. We studied nine subjects (eight men and one woman; mean age±SD: 31.3±11.0 yr) with mild intermittent allergic asthma, never treated with regular beta2-agonists or inhaled corticosteroids. In a previous allergen challenge all ...
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#1Nicolino AmbrosinoH-Index: 66
#2Soo-Kyung StrambiH-Index: 6
Last. D GianniniH-Index: 22
view all 6 authors...
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#1Fl Dente (UniPi: University of Pisa)H-Index: 19
#2Elena Bacci (UniPi: University of Pisa)H-Index: 27
Last. Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
view all 9 authors...
Abstract Salmeterol is an effective long-acting β 2 -agonist bronchodilator, able to inhibit, as a single dose, asthmatic responses induced by several stimuli including allergen, and the subsequent increase in sputum eosinophilia. Aim of the present study was to investigate whether these effects of salmeterol persisted after 1 week of continuous treatment, or whether a loss of the bronchoprotective effects of salmeterol can occur over time. We investigated in a cross-over double blind placebo-co...
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#10Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
In the aim to evaluate the relationship between sputum eosinophil percentages and eosinophil cationic protein (ECP) concentrations, as markers of airway inflammation, and different levels of asthma severity, we examined 223 patients consecutively observed in our asthma clinic. Diagnosis of asthma was made according to internationally accepted criteria. Asthma severity was evaluated according to frequency of symptoms, FEV1, peak expiratory flow variability and level of asthma treatment needed to ...
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#1D Giannini (UniPi: University of Pisa)H-Index: 22
#2Antonella Di Franco (UniPi: University of Pisa)H-Index: 14
Last. Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
view all 9 authors...
Abstract The aim of this study was to assess the distribution of the occurrence of tolerance to the protective effect of salmeterol on allergen challenge in a large sample of asthmatic subjects. We investigated 53 subjects (45 male and eight female), mean age 24±8.2 years, with mild intermittent asthma, in stable phase of the disease, never previously treated with regular β 2 -agonists. All subjects with a previous positive early airway response (EAR) to a screening allergen challenge underwent,...
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#1M Tonelli (UniPi: University of Pisa)H-Index: 5
#2M. Zingoni (UniPi: University of Pisa)H-Index: 5
Last. Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
view all 9 authors...
Abstract In a single blind study, the short-term efficacy of the addition of leukotriene receptor antagonists (LTRA: montelukast 10 mg o.d. in 15 subjects, zafirlukast 20 mg b.i.d. in 11 subjects) to the current therapy was evaluated in severe asthmatics, unstable under regular treatment with high dose inhaled corticosteroids, bronchodilators and, in seven of them, oral corticosteroids. Each subject monitored symptoms, PEF and rescue medication during two weeks with the addition of placebo, and ...
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#1D Giannini (UniPi: University of Pisa)H-Index: 22
#2A Di Franco (UniPi: University of Pisa)H-Index: 19
Last. Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
view all 10 authors...
Abstract Twenty-seven subjects with moderate asthma at the time of diagnosis, well controlled under regular fluticasone propionate (FP) (250 μg b.i.d.) for 6 months at least, were randomized to receive in double-blind fashion: FP 125 μg b.i.d. (Group 1) or FP 50 μg b.i.d. (Group 2) or placebo (Group 3) for 3 months or until symptom recurrence. Daily symptom score and peak expiratory flow were monitored. At the beginning and at the end of the study, subjects underwent methacholine challenge and s...
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#1Antonella Di Franco (UniPi: University of Pisa)H-Index: 14
#2Maria Laura Bartoli (UniPi: University of Pisa)H-Index: 14
Last. Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
view all 10 authors...
Background. Acute airway inflammation is considered to characterize asthma exacerbations, but its specific cellular pattern has not yet been completely evaluated. Aim. To evaluate the prevalence of sputum eosinophilia during acute asthma exacerbations of moderate severity, compared with a stable phase of the disease, and to assess the concordance between changes in pulmonary function and sputum eosinophilia in the period between exacerbation and post exacerbation. Methods. We compared sputum and...
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#1Barbara Vagaggini (UniPi: University of Pisa)H-Index: 29
#2M TaccolaH-Index: 13
Last. Pierluigi PaggiaroH-Index: 55
view all 10 authors...
We investigated whether exposure to ozone (O3) 24 hours after an allergen challenge test would increase airway eosinophilia induced by allergen in subjects with mild asthma with late airway response. Twelve subjects with mild atopic asthma participated in a randomized, single-blind study. Subjects underwent allergen challenge 24 hours before a 2 hour exposure to O3 (0.27 ppm) or filtered air. Pulmonary function was monitored during the allergen challenge and after the exposure to O3 or air. Six ...
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#1Elena Bacci (UniPi: University of Pisa)H-Index: 27
#2Silvana CianchettiH-Index: 23
Last. Pierluigi PaggiaroH-Index: 55
view all 9 authors...
To evaluate the reproducibility of induced sputum analysis, and to estimate the sample size required to obtained reliable results, sputum was induced by hypertonic saline inhalation in 29 asthmatic subjects on two different days. The whole sample method was used for analysis, and inflammatory cells were counted on cytospin slides. Reproducibility, expressed by intra-class correlation coefficients, was good for macrophages (+0.80), neutrophils (+0.85), and eosinophils (+0.87), but not for lymphoc...
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