Robin F. Chan
Virginia Commonwealth University
GeneGenome-wide association studyFramingham Risk ScorePsychiatryEpigenomicsInternal medicineEndocrinologyMental healthCpG siteOncologyEconometricsGene expressionSingle-nucleotide polymorphismDifferentially methylated regionsNeuroscienceGene knockdownAlleleGenetic associationBisulfite sequencingDNA methylationImmunologySensitivity (control systems)InflammationDepression (differential diagnoses)Drug toleranceMajor depressive disorderDrosophila melanogasterEthanolAlcoholReplicatePopulationMethylationEpigeneticsGeneticsAnxietyClinical psychologyComputational biologyMedicineBiology
34Publications
13H-index
426Citations
Publications 35
Newest
#1Shaunna L. Clark (A&M: Texas A&M University)H-Index: 24
#2Robin F. Chan (VCU: Virginia Commonwealth University)H-Index: 13
Last. Edwin J.C.G. van den Oord (VCU: Virginia Commonwealth University)H-Index: 48
view all 8 authors...
Using an integrative, multi-tissue design, we sought to characterize methylation and hydroxymethylation changes in blood and brain associated with alcohol use disorder (AUD). First, we used epigenomic deconvolution to perform cell-type-specific methylome-wide association studies within subpopulations of granulocytes/T-cells/B-cells/monocytes in 1132 blood samples. Blood findings were then examined for overlap with AUD-related associations with methylation and hydroxymethylation in 50 human post-...
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#1Robin F. Chan (VCU: Virginia Commonwealth University)H-Index: 13
#2William E. Copeland (University of Vermont Medical Center)H-Index: 53
Last. Edwin J.C.G. van den Oord (VCU: Virginia Commonwealth University)H-Index: 48
view all 7 authors...
BACKGROUND Women are 1.5-3 times more likely to suffer from depression than men. This sex bias first emerges during puberty and then persists across the reproductive years. As the cause remains largely elusive, we performed a methylation-wide association study (MWAS) to generate novel hypotheses. METHODS We assayed nearly all 28 million possible methylation sites in blood in 595 blood samples from 487 participants aged 9-17. MWASs were performed to identify methylation sites associated with incr...
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#1Shaunna L. Clark (A&M: Texas A&M University)H-Index: 24
#2Robin F. Chan (UVM: University of Vermont)H-Index: 13
Last. Edwin J.C.G. van den Oord (VCU: Virginia Commonwealth University)H-Index: 48
view all 7 authors...
Abstract Objective The impact of adolescent cannabis use is a pressing public health question due to the high rates of use and links to negative outcomes. Here we consider the association between problematic adolescent cannabis use and methylation. Method Using an enrichment-based sequencing approach, we performed a methylome-wide association study (MWAS) of problematic adolescent cannabis use in 703 adolescent samples from the Great Smoky Mountain Study. Using epigenomic deconvolution, we perfo...
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#1Shaunna L. Clark (A&M: Texas A&M University)H-Index: 24
#2Robin F. ChanH-Index: 13
Last. Edwin J.C.G. van den Oord (VCU: Virginia Commonwealth University)H-Index: 48
view all 8 authors...
Background: Using a three-stage, multi-tissue design we sought to characterize methylation and hydroxymethylation changes in blood and brain associated with alcohol use disorder (AUD). Methods: In the discovery stage, we used epigenomic deconvolution to perform cell-type specific methylome-wide association studies within subpopulations of granulocytes/T-cells/B-cells/monocytes in 1,132 blood samples. Blood findings were examined for overlap with AUD-related methylation and hydroxymethylation in ...
Source
#1Shaunna L. Clark (VCU: Virginia Commonwealth University)H-Index: 24
#2Mohammad W. Hattab (VCU: Virginia Commonwealth University)H-Index: 6
Last. Edwin J.C.G. van den Oord (VCU: Virginia Commonwealth University)H-Index: 48
view all 14 authors...
Recurrent and chronic major depressive disorder (MDD) accounts for a substantial part of the disease burden because this course is most prevalent and typically requires long-term treatment. We associated blood DNA methylation profiles from 581 MDD patients at baseline with MDD status 6 years later. A resampling approach showed a highly significant association between methylation profiles in blood at baseline and future disease status (P = 2.0 × 10−16). Top MWAS results were enriched specific pat...
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#1Karolina A. Aberg (VCU: Virginia Commonwealth University)H-Index: 27
#2Brian Dean (Centre for Mental Health)H-Index: 65
Last. Edwin J.C.G. van den Oord (VCU: Virginia Commonwealth University)H-Index: 48
view all 13 authors...
We present the first large-scale methylome-wide association studies (MWAS) for major depressive disorder (MDD) to identify sites of potential importance for MDD etiology. Using a sequencing-based approach that provides near-complete coverage of all 28 million common CpGs in the human genome, we assay methylation in MDD cases and controls from both blood (N = 1132) and postmortem brain tissues (N = 61 samples from Brodmann Area 10, BA10). The MWAS for blood identified several loci with P ranging ...
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#1Jerry Guintivano (UNC: University of North Carolina at Chapel Hill)H-Index: 6
#2Andrey A. Shabalin (UofU: University of Utah)H-Index: 26
Last. Edwin J.C.G. van den Oord (VCU: Virginia Commonwealth University)H-Index: 48
view all 8 authors...
Recent years have seen a surge of methylome-wide association studies (MWAS). We observed that many of these studies suffer from test statistic inflation that is most likely caused by commonly used ...
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#1Karolina A. Aberg (VCU: Virginia Commonwealth University)H-Index: 27
#2Robin F. Chan (VCU: Virginia Commonwealth University)H-Index: 13
Last. Edwin J.C.G. van den Oord (VCU: Virginia Commonwealth University)H-Index: 48
view all 3 authors...
AbstractThe majority of methylome-wide association studies (MWAS) have been performed using commercially available array-based technologies such as the Infinium Human Methylation 450K and the Infin...
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#1Robin F. Chan (VCU: Virginia Commonwealth University)H-Index: 13
#2Gustavo Turecki (Douglas Mental Health University Institute)H-Index: 113
Last. Edwin J.C.G. van den Oord (VCU: Virginia Commonwealth University)H-Index: 48
view all 12 authors...
ABSTRACT Background We sought to characterize methylation changes in brain and blood associated with major depressive disorder (MDD). As analyses of bulk tissue may obscure association signals and hamper the biological interpretation of findings, these changes were studied on a cell-type-specific level. Methods In three collections of human postmortem brain (N=206) and one collection of blood samples (N=1,132) of MDD cases and controls, we used epigenomic deconvolution to perform cell-type-speci...
Source
#1Robin F. Chan (VCU: Virginia Commonwealth University)H-Index: 13
#2Andrey A. Shabalin (VCU: Virginia Commonwealth University)H-Index: 26
Last. Karolina A. Aberg (VCU: Virginia Commonwealth University)H-Index: 27
view all 10 authors...
Methylome-wide association studies (MWASs) are promising complements to sequence variation studies. We used existing sequencing-based methylation data, which assayed the majority of all 28 million CpGs in the human genome, to perform an MWAS for schizophrenia in blood, while controlling for cell-type heterogeneity with a recently generated platform-specific reference panel. Next, we compared the MWAS results with findings from 3 existing large-scale array-based schizophrenia methylation studies ...
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