Aiko Sakamoto
University of Tokyo
Angiotensin II receptor type 1EndocrinologyPathologyOdds ratioCardiologyReceptorAdipose tissueRenin–angiotensin systemRetroperitoneal fibrosisAortic aneurysmInsulin resistanceCoronary artery diseasePioglitazoneFibrosisAngiotensin IIRisk factorQuartileMedicineBiomarker (medicine)Gastroenterology
35Publications
8H-index
229Citations
Publications 35
Newest
#1Aiko SakamotoH-Index: 8
#2Nobukazu IshizakaH-Index: 34
Last. Issei KomuroH-Index: 90
view all 6 authors...
Background: Inflammation is a principal contributor to the progression of atherosclerosis. However, it remains unclear whether immunoglobulin G4 (IgG4)-related immuno-inflammation may directly prom...
#1Aiko SakamotoH-Index: 8
#2Nobukazu IshizakaH-Index: 34
Last. Issei KomuroH-Index: 90
view all 5 authors...
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) may contribute to the development of cardiovascular disease. However, the association of elevated serum PCSK9 levels with the incid...
#1Aiko SakamotoH-Index: 8
#2Nobukazu IshizakaH-Index: 34
Last. Issei KomuroH-Index: 90
view all 5 authors...
Background: Atherosclerotic coronary plaques with a large lipid core have a strong association with acute coronary syndrome. Although inflammatory processes contribute to the development of vulnera...
#1Aiko SakamotoH-Index: 8
#2Masae UeharaH-Index: 18
Last. Issei KomuroH-Index: 90
view all 5 authors...
Background: Ectopic fat deposition, such as pericardial adipose tissue (PAT) and intrathoracic adipose tissue (IAT), may mediate obesity-related cardiovascular disease. However, it remains unclear ...
#1Aiko Sakamoto (UTokyo: University of Tokyo)H-Index: 8
#2Tomofumi Tanaka (UTokyo: University of Tokyo)H-Index: 6
Last. Issei Komuro (UTokyo: University of Tokyo)H-Index: 90
view all 5 authors...
Immunoglobulin G4 (IgG4)-related disease is a systemic inflammatory disorder that was first described in patients with autoimmune pancreatitis. Although IgG4-related disease is thought to involve the cardiovascular system, case reports describing coronary artery involvement are relatively rare. We describe a patient who was previously diagnosed with autoimmune pancreatitis and found to have coronary periarteritis and luminal narrowing. After the initiation of steroid treatment, the patient's cor...
7 CitationsSource
#1Aiko SakamotoH-Index: 8
#2Masae UeharaH-Index: 18
Last. Issei KomuroH-Index: 90
view all 5 authors...
Background: Pericardial fat is recognized as a risk factor for coronary stenosis. However, it remains unclear whether ectopic fat deposition, such as pericardial fat and intrathoracic fat, is an in...
#1Aiko SakamotoH-Index: 8
#2Nobukazu IshizakaH-Index: 34
Last. Issei KomuroH-Index: 90
view all 5 authors...
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) may directly promote atherosclerosis. However, the long-term impact of elevated serum PCSK9 levels on the risk of cardiovascular ev...
#1Aiko Sakamoto (UTokyo: University of Tokyo)H-Index: 8
#2Nobukazu Ishizaka (Osaka Medical College)H-Index: 34
Last. Issei Komuro (UTokyo: University of Tokyo)H-Index: 90
view all 7 authors...
Abstract Background Immunoglobulin G4 (IgG4)-related immuno-inflammation has been suggested to affect the development of coronary artery atherosclerosis. The aim of this study was to analyze the association of serum IgG4 concentrations with calcified and non-calcified coronary plaques. Methods Serum IgG4 concentrations were measured in 263 patients who underwent 320-slice coronary computed tomographic (CT) angiography. Vulnerable coronary plaques were evaluated for CT plaque characteristics, inc...
3 CitationsSource
#1Aiko Sakamoto (UTokyo: University of Tokyo)H-Index: 8
#2Yasutomi Higashikuni (UTokyo: University of Tokyo)H-Index: 13
Last. Nobukazu Ishizaka (Osaka Medical College)H-Index: 34
view all 8 authors...
In an insulin-resistant state, excess lipids may accumulate in various non-adipose tissues, leading to histological and functional damage. It has been suggested that peroxisome proliferator-activated receptor-gamma (PPARγ) may ameliorate disorganized lipid balance. In the current study, we analyzed whether pioglitazone, an agonist of PPARγ, reduces angiotensin II-induced vascular lipid accumulation.Angiotensin II was infused into rats at doses of 0.7 mg/kg/day via a subcutaneously implanted osmo...
2 CitationsSource
#1Aiko SakamotoH-Index: 8
#2Masae UeharaH-Index: 18
Last. Issei KomuroH-Index: 90
view all 6 authors...
Background: Epicardial fat volume (EFV) is recognized as an independent risk factor for coronary atherosclerosis. However, it remains unclear whether the computed tomography (CT) attenuation value ...
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