Neeraj Chauhan
Rutgers University
CancerMutantCorpus albicansMolecular biologyVirologyChemistryApoptosisImmunologyOrmeloxifeneCervical cancerCurcuminHistidine kinasePancreatic cancerCandida albicansResponse regulatorCancer researchVirulenceCell growthMedicineBiologyMicrobiology
Publications 93
Health care facilities are facing serious threats by the recently emerging human fungal pathogen Candida auris owing to its pronounced antifungal multidrug resistance and poor diagnostic tools. Distinct C. auris clades evolved seemingly simultaneously at independent geographical locations and display both genetic and phenotypic diversity. Although comparative genomics and phenotypic profiling studies are increasing, we still lack mechanistic knowledge about the C. auris species diversification a...
1 CitationsSource
#1Benilde Adriano (University of Texas at Austin)H-Index: 1
#2Nycol M. Cotto (University of Texas at Austin)H-Index: 1
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 34
view all 6 authors...
Abstract Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles. Exosomes have proven to be excellent nanocarriers for carrying lipids, proteins, mRNAs, non-coding RNAs, and DNAs, and disseminating long-distance intercellular communications in various biological processes. Among various cell-line or biological fluid derived exosomes, milk exosomes are abundant in nature and exhibit many nanocarrier characte...
#1Neeraj Chauhan (University of Texas at Austin)H-Index: 24
#1Neeraj Chauhan (University of Texas at Austin)H-Index: 1
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 34
view all 4 authors...
The novel coronavirus (CoV) disease 2019 (COVID-19) is a viral infection that causes severe acute respiratory syndrome (SARS). It is believed that early reports of COVID-19 cases were noticed in De...
6 CitationsSource
#1Raju Shivarathri (RU: Rutgers University)H-Index: 3
#2Sabrina Jenull (Medical University of Vienna)H-Index: 8
Last. Neeraj Chauhan (RU: Rutgers University)H-Index: 24
view all 10 authors...
ABSTRACT Candida auris is an emerging multidrug-resistant human fungal pathogen refractory to treatment by several classes of antifungal drugs. Unlike other Candida species, C. auris can adhere to human skin for prolonged periods of time, allowing for efficient skin-to-skin transmission in the hospital environments. However, molecular mechanisms underlying pronounced multidrug resistance and adhesion traits are poorly understood. Two-component signal transduction and mitogen-activated protein (M...
#1Neeraj Chauhan (University of Texas at Austin)H-Index: 1
#1Neeraj Chauhan (University of Texas at Austin)H-Index: 24
Last. Murali M. YallapuH-Index: 34
view all 5 authors...
microRNAs (miRNAs) are a class of small non-coding RNAs that regulate the expression of their target mRNAs post transcriptionally. miRNAs are known to regulate not just a gene but the whole gene network (signaling pathways). Accumulating evidence(s) suggests that miRNAs can work either as oncogenes or tumor suppressors, but some miRNAs have a dual nature since they can act as both. miRNA 205 (miR-205) is one such highly conserved miRNA that can act as both, oncomiRNA and tumor suppressor. Howeve...
4 CitationsSource
#1Suraya Muzafar (RU: Rutgers University)H-Index: 1
#2Ravi Datta Sharma (Amity University)H-Index: 6
Last. Rajendra Prasad (Amity University)H-Index: 89
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ABSTRACT Alternative splicing (AS)—a process by which a single gene gives rise to different protein isoforms in eukaryotes—has been implicated in many basic cellular processes, but little is known about its role in drug resistance and fungal pathogenesis. The most common human fungal pathogen, Candida albicans, has introns in 4 to 6% of its genes, the functions of which remain largely unknown. Here, we report AS regulating drug resistance in C. albicans. Comparative RNA-sequencing of two differe...
1 CitationsSource
#1Vivek Kumar Kashyap (UTHSC: University of Tennessee Health Science Center)H-Index: 1
#1Vivek K. Kashyap (UTHSC: University of Tennessee Health Science Center)H-Index: 8
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 49
view all 14 authors...
Abstract In this study, we investigated the therapeutic efficacy of VERU-111 in vitro and in vivo model systems of cervical cancer. VERU-111 treatment inhibited cell proliferation and, clonogenic potential, induce accumulation of p53 and down regulated the expression of HPV E6/E7 expression in cervical cancer cells. In addition, VERU-111 treatment also decreased the expression of phosphorylation of Jak2 (TyR1007/1008) and STAT3 at Tyr705 and Ser727. VERU-111 treatment arrested cell cycle in the ...
2 CitationsSource
#1Neeraj Chauhan (University of Texas at Austin)H-Index: 24
#1Neeraj Chauhan (University of Texas at Austin)H-Index: 1
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 49
view all 6 authors...
Utilization of safe cytotoxic agents with precise anticancer activity is considered as the prime focus of cancer therapeutics research. A greater incentive for such agents arises from the molecules/drugs that are already being used for other indications. Ormeloxifene (ORM) is a nonsteroidal, nonhormonal selective estrogen receptor modulator (SERM), which has been in human use for contraception purposes. Although in the recent past, many reports have suggested its emerging role as an anticancer a...
#1Mohammed Sikander (UTHSC: University of Tennessee Health Science Center)H-Index: 7
#2Shabnam Malik (UTHSC: University of Tennessee Health Science Center)H-Index: 8
Last. Subhash C. ChauhanH-Index: 49
view all 11 authors...
Pancreatic cancer (PanCa) is one of the leading causes of death from cancer in the United States. The current standard treatment for pancreatic cancer is gemcitabine, but its success is poor due to the emergence of drug resistance. Natural products have been widely investigated as potential candidates in cancer therapies, and cucurbitacin D (Cuc D) has shown excellent anticancer properties in various models. However, there is no report on the therapeutic effect of Cuc D in PanCa. In the present ...
4 CitationsSource
#1Tanvi Govil (SDSM&T: South Dakota School of Mines and Technology)H-Index: 5
#2Wageesha Sharma (JUIT: Jaypee University of Information Technology)H-Index: 1
Last. Rajesh K. Sani (SDSM&T: South Dakota School of Mines and Technology)H-Index: 31
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Abstract Successful and efficient extraction of high quality, high molecular weight genomic DNA from the environmental samples is an essential primary step to understand the genetic, metabolic and evolutionary characteristics of the microbial communities. Deep mine biofilm samples that contain high amounts of mucoid exopolysaccharide often pose difficulties to obtaining refined community DNA. To circumvent this hindrance, we report our “MINES” method which we developed for optimal biofilm DNA re...
1 CitationsSource