Shinya Furukawa
Ehime University
Internal medicineEndocrinologyCross-sectional studyOdds ratioVirologyImmunologyNonalcoholic fatty liver diseaseType 2 diabetesCirrhosisFatty liverDiseasePregnancyBody mass indexUlcerative colitisMotilin receptorType 2 Diabetes MellitusIn patientHepatologyConfidence intervalRisk factorDiabetes mellitusMedicineGastroenterology
Publications 139
#1Teruki Miyake (Ehime University)H-Index: 19
#1Teruki Miyake (Ehime University)H-Index: 9
Last. Morikazu Onji (Ehime University)H-Index: 16
view all 13 authors...
Background Untreated nonalcoholic fatty liver disease (NAFLD) may progress to liver cirrhosis or failure and is associated with the development of hepatocellular carcinoma, diabetes, and cardiovascular disease. It is therefore essential to diagnose and treat NAFLD at an early stage. To assist in this effort, this retrospective study explored the risk factors for NAFLD, and derived new surrogates, a revised alanine aminotransferase (ALT) cutoff level and a novel NAFLD index, to identify previousl...
41 CitationsSource
#1Teruki Miyake (Ehime University)H-Index: 19
#1Teruki Miyake (Ehime University)H-Index: 9
Last. Morikazu Onji (Ehime University)H-Index: 16
view all 12 authors...
Branched-chain amino acid (BCAA) supplements have mainly been administered as a nutritional intervention for decompensated liver cirrhosis. Several studies have shown that short-term BCAA supplementation improves insulin and glucose tolerance in patients with liver cirrhosis. However, the long-term effects of BCAA supplementation on glucose tolerance and in patients with nonalcoholic steatohepatitis (NASH)-related liver cirrhosis are unknown. Herein, we report 2 cases of NASH-related liver cirrh...
25 CitationsSource
#2Shinya FurukawaH-Index: 26
Last. Morikazu OnjiH-Index: 62
view all 13 authors...
症例は25歳 女性.ダウン症候群と診断され,幼少期に心室中隔欠損症術を受けた際に輸血あり.20歳時にC型肝炎ウイルス(HCV)の感染を指摘された.肝機能異常あり,HCV genotype 2a,ウイルス量3.2 logIU/ml であった.インターフェロン適応ありと判断し,ペグインターフェロンα-2aを投与した.しかし白血球減少症を来し,以後インターフェロンβに切り替え投与した.その後合併症なく治療を完遂し,HCV-RNA陰性化およびトランスアミナーゼ正常化が得られた.ダウン症候群合併C型肝炎では,インターフェロンによるウイルス学的著効が得られる症例は稀とされている.また精神的な副作用を予測し難いため,治療をためらう事例も多い.しかし近年,ダウン症候群の余命は延長し,C型肝炎合併例では肝炎が予後を左右する場合もある.本症例は,ウイルス側および宿主側に著効し易い素因を持ち,かつインターフェロンβによる治療完遂が可能であった.この様な症例では積極的な抗ウイルス療法を考慮する必要がある.
#1Takashi Moritoyo (Ehime University)H-Index: 8
#2Tomoko Hasunuma (Kitasato University)H-Index: 9
Last. Masahiro Nomoto (Ehime University)H-Index: 18
view all 46 authors...
The effect of renal impairment on the pharmacokinetics of a single oral dose of me- mantine (10 mg) was determined in Japanese subjects. Subjects were assigned to four groups based on baseline creatinine clearance (CLCR): normal renal function (> 80 mL/min, n = 6), and mild (50 to ≤ 80 mL/min, n = 6), moderate (30 to < 50 mL/min, n = 6), and severe renal impair- ment (5 to < 30 mL/min, n = 7). Mean memantine maximum plasma concentration (Cmax) was similar in the groups (12.66, 17.25, 15.75, and ...
6 CitationsSource
#1Shinya Furukawa (Ehime University)H-Index: 26
#2Teru Kumagi (Ehime University)H-Index: 30
Last. Morikazu Onji (Ehime University)H-Index: 16
view all 10 authors...
Dipeptidyl peptidase-4 (DPP-4) inhibitors are a newer class of oral hypoglycemic agents for the management of diabetes that elevate the plasma concentration of active glucagon-like peptide-1 via inhibition of DPP-4. They effectively lower not only glycosylated hemoglobin levels, but also fasting and postprandial plasma glucose levels. Patients with diabetes occasionally consume an overdose of oral hypoglycemic agents in suicide attempts: the prevalence of depression is high in patients with diab...
13 CitationsSource
#1Maho Hamada (Ehime University)H-Index: 6
#2Masanori Abe (Ehime University)H-Index: 50
Last. Morikazu Onji (Ehime University)H-Index: 16
view all 9 authors...
Visceral adipose tissue (VAT) inflammation has been linked to the pathogenesis of insulin resistance and metabolic syndrome. VAT has recently been established as a new component of the immune system and is involved in the production of various adipokines and cytokines. These molecules contribute to inducing and accelerating systemic insulin resistance. In this report, we investigated the role of B cell-activating factor (BAFF) in the induction of insulin resistance. We investigated BAFF levels i...
36 CitationsSource
#1Ichiro Konishi (Ehime University)H-Index: 13
#2Yoichi Hiasa (Ehime University)H-Index: 53
Last. Morikazu Onji (Ehime University)H-Index: 16
view all 8 authors...
Aim: Hepatitis C virus infection often complicates glucose intolerance, which can be caused by insulin resistance. Aerobic exercise can improve insulin resistance and decrease body fat in patients with diabetes. The aim of the present study is to clarify whether aerobic exercise improves insulin resistance and decreases body fat in patients with chronic hepatitis C (CH-C). Methods: Seventeen patients with CH-C received nutrition education at entry and every two months thereafter. The following w...
29 CitationsSource
#1Takao Watanabe (Ehime University)H-Index: 10
#2Yoichi Hiasa (Ehime University)H-Index: 53
Last. Morikazu Onji (Ehime University)H-Index: 62
view all 16 authors...
A 77-year-old man with hypertension, diabetes mellitus, ischemic heart disease and a smoking habit presented at our hospital with sudden abdominal pain. Computed tomography indicated edematous swelling and pneumatosis of the intestinal wall in a localized area of the ascending colon with inflamed adipose tissue. Acute mesenteric ischemia was diagnosed. Abdominal angiography showed stenosis of the mesenteric arteries. Virtual histology–intravascular ultrasound imaging indicated a fibrous change i...
#1S. M. F. Akbar (Toshiba)H-Index: 6
#2Shinya Furukawa (Toshiba)H-Index: 26
Last. Morikazu Onji (Toshiba)H-Index: 16
view all 6 authors...
Summary. The immune modulator capacity of antigen-pulsed dendritic cells (DC) has been documented in patients with cancers and in animal models of chronic viral infections. Cancer antigen-pulsed DC are now used for treating patients with cancer. But viral antigen-pulsed DC are not used in chronic viral-infected patients because safety of antigen-pulsed DC has not been evaluated in these patients. DC were isolated from human peripheral blood mononuclear cells by culturing with human-grade granulo...
29 CitationsSource
#1Teruhisa UedaH-Index: 11
#2Bunzo MatsuuraH-Index: 31
Last. Morikazu OnjiH-Index: 16
view all 8 authors...
The Class A family of guanine nucleotide-binding protein (G protein)-coupled receptors that includes receptors for motilin, ghrelin, and growth hormone secretagogue (GHS) has substantial potential importance as drug targets. Understanding of the molecular basis of hormone binding and receptor activation should provide insights helpful in the development of such drugs. We previously reported that Cys residues and the perimembranous residues in the extracellular loops and amino-terminal tail of th...