Shiwen Xu
Northeast Agricultural University
Messenger RNAInternal medicineEndocrinologyMolecular biologyChemistryApoptosisImmunologySuperoxide dismutaseOxidative stressSelenoproteinInflammationCommon carpGlutathione peroxidaseSelenium deficiencySelenoprotein WSeleniumBiochemistryBiologyImmune systemCell biology
180Publications
52H-index
5,160Citations
Publications 186
Newest
#1Zhiying Miao (NEAU: Northeast Agricultural University)
#2Zhiruo Miao (NEAU: Northeast Agricultural University)
Last. Shiwen Xu (NEAU: Northeast Agricultural University)H-Index: 52
view all 4 authors...
Abstract null null Chlorpyrifos (CPF), a widely used organophosphorus pesticide has caused water pollution, threatening aquatic organisms. MicroRNAs (miRNAs) highly conserved noncoding RNAs, that regulate various cell death processes, including pyroptosis. To investigate the effect of CPF exposure on epithelioma papulosum cyprini (EPC) cell pyroptosis and the role of the miR-124-3p/CAPN1 axis, we established miR-124 overexpression and inhibition EPC cell models of CPF exposure. The target of the...
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#1Qianru Chi (NEAU: Northeast Agricultural University)H-Index: 7
#2Xueyuan Hu (NEAU: Northeast Agricultural University)H-Index: 9
Last. Shu Li (NEAU: Northeast Agricultural University)H-Index: 29
view all 7 authors...
Abstract null null Hydrogen sulfide (H2S) is a common toxic gas in chicken houses that endangers the health of poultry. Harbin has a cold climate in winter, and the conflict between heat preservation and ventilation in poultry houses is obvious. In this study, we investigated the H2S content in chicken houses during winter in Harbin and found that the H2S concentration exceeded the national standard in individual chicken houses. Then, a model of H2S exposure was established in an environmental s...
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#1Yilin Yin (NEAU: Northeast Agricultural University)
#2Jinming Guo (NEAU: Northeast Agricultural University)
Last. Shufang Zheng (NEAU: Northeast Agricultural University)H-Index: 10
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Selenium (Se) is an essential trace element found in the body. Se deficiency and M1/M2 imbalance are closely related to inflammation. Heat stress can decrease immune function and cause inflammation. In order to investigate whether Se deficiency can aggravate pneumonia caused by heat stress and the role of M1/M2 imbalance in the occurrence of pneumonia, 100 AA broilers were divided into two groups and fed the conventional diet (0.2 mg/kg Se) and the Se-deficient diet (0.03 mg/kg Se). After 40 day...
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#1Yujie Yao (NEAU: Northeast Agricultural University)H-Index: 1
#2Xia Zhao (NEAU: Northeast Agricultural University)H-Index: 10
Last. Shiwen Xu (NEAU: Northeast Agricultural University)H-Index: 52
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Abstract null null Cadmium (Cd) is a widely distributed environmental pollutant with immunotoxicity and endocrine toxicity. M1/M2 macrophages participate in the immune response and exert an essential influence on fibrosis. Nevertheless, whether Cd can induce porcineadrenal fibrosis by affecting the polarization of M1/M2 macrophages and its potential regulatory mechanism have not been explored. We added 20 mg/kg CdCl2 to the pig diet for 40 days to investigate the fibrogenic effect of subacute Cd...
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#1Zhiruo Miao (NEAU: Northeast Agricultural University)
#2Zhiying Miao (NEAU: Northeast Agricultural University)
Last. Shiwen Xu (NEAU: Northeast Agricultural University)H-Index: 52
view all 5 authors...
Abstract null null Imidacloprid (IMI) is widely used in agriculture, and is toxic to non-target aquatic species. Quercetin (Que) is a flavonoid abundant in fruits and vegetables that exhibits anti-oxidant activity. In the present study, we treated grass carp hepatocytes (L8824) with 0.1 μM Que and/or 1 mM IMI for 24 h to explore the effect of Que on IMI-induced mitochondrial apoptosis. We found that IMI exposure enhanced reactive oxygen species (ROS) generation, inhibiting the activities of SOD,...
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#1Bing Wang (NEAU: Northeast Agricultural University)H-Index: 2
#2Yuan Cui (NEAU: Northeast Agricultural University)H-Index: 5
Last. Shiwen Xu (NEAU: Northeast Agricultural University)H-Index: 52
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Selenium (Se) was involved in many physiological processes in humans and animals. microRNAs (miRNAs) also played important roles in lung diseases. However, the regulatory mechanism of miRNA in chicken lungs and the mechanism of lipopolysaccharide (LPS)-induced pneumonia remained unclear. To further study these mechanisms, we established a supplement of selenomethionine (SeMet) and/or LPS-treated chicken model and a cell model of LPS and/or high and low expression of miR-15a in chicken hepatocell...
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#1Qianru Chi (NEAU: Northeast Agricultural University)H-Index: 7
#2Qing Zhang (NEAU: Northeast Agricultural University)
Last. Shu Li (NEAU: Northeast Agricultural University)H-Index: 29
view all 6 authors...
ABSTRACT Selenium (Se) deficiency and poor plasma Se levels can cause cardiovascular diseases by decreasing selenoprotein levels. Neutrophil extracellular traps (NETs) may be the vicious cycle center of inflammation in vasculitis. Here, we show that Se deficiency induced arteritis mainly by reducing selenoprotein S (SelS), and promoted the progression of arteritis by regulating the recruitment of neutrophils and NET formation. Silencing SelS induced chicken arterial endothelial cells (PAECs) to ...
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#1Linfei Jiao (NEAU: Northeast Agricultural University)
#2Zichan He (NEAU: Northeast Agricultural University)
Last. Shiwen Xu (NEAU: Northeast Agricultural University)H-Index: 52
view all 5 authors...
Selenium (Se) is an essential trace element in creatures which deficiency can cause necroptosis and inflammation of multiple tissues. MicroRNAs (miRNAs) have been identified to participate multiple biological processes by regulating the expression of target genes. In the present study, the Se-deficient pig cerebellar model was established and conducted by light microscopy, qRT-PCR, and Western blot. Morphological observation exhibited necrosis-like lesions and inflammatory infiltration in the ce...
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#1Hao Wu (NEAU: Northeast Agricultural University)
#2Shufang Zheng (NEAU: Northeast Agricultural University)H-Index: 10
Last. Zhiruo Miao (NEAU: Northeast Agricultural University)
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Abstract Cadmium (Cd), an environmental pollutant, causes several adverse reactions in animals. High dose of Cd has serious cytotoxicities, including the induction of programmed cell necrosis, autophagy and apoptosis, which has aroused wide public concern. The balance of cytokine network is affected by Th1/Th2 balance which is closely related to immune response and the occurrence, development, treatment and outcome of various diseases. Cd can induce severe apoptosis, but the relationship between...
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#1Nuan SongH-Index: 1
#2Wei Wang (NEAU: Northeast Agricultural University)H-Index: 7
Last. Meng-yao GuoH-Index: 1
view all 6 authors...
Abstract Hydrogen sulfide (H2S) is an environmental contaminant to cause the airway damage. The release of macrophage extracellular traps (METs) is the mechanism of immune protection to harmful stimulation via microRNAs, but excessive METs cause the injury. However, few studies have attempted to interpret the mechanism of an organism injury due to H2S via METs in chickens. Here, we investigated the transcriptome profiles, pathological morphologic changes and METs release from chicken trachea aft...
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