Chang-Mu Chen
National Taiwan University
RadiologyEndocrinologySurgeryChemistryVestibular systemNeuroprotectionOxidative stressVestibular evoked myogenic potentialKidney diseaseBrain ischemiaKidneyReperfusion injuryRadiosurgeryAudiometrySchwannomaRenal fibrosisIschemiaAudiologyMedicinePharmacology
Publications 23
#1Chang-Mu ChenH-Index: 11
#2Yao-Pang Chung (NTU: National Taiwan University)H-Index: 3
Last. Shing-Hwa LiuH-Index: 44
view all 8 authors...
1 CitationsSource
#1Chang-Mu Chen (NTU: National Taiwan University)H-Index: 11
#2Min-Ni Chung (NTU: National Taiwan University)H-Index: 1
Last. Kuo-Cheng Lan (NDMC: National Defense Medical Center)H-Index: 9
view all 5 authors...
Arsenic is a toxic metalloid. Infants with a low birth-weight have been observed in areas with high-level arsenic in drinking water ranging from 463 to 1025 μg/L. A distal muscular atrophy side effect has been observed in acute promyelocytic leukemia patients treated with arsenic trioxide (As2O3) for therapy. The potential of As2O3 on muscle atrophy remains to be clarified. In this study, the myoatrophic effect of arsenic was evaluated in normal mice and sciatic nerve denervated mice exposed wit...
#1Sheng-Che Chou (NTU: National Taiwan University)H-Index: 2
#2Meng-Fai Kuo (NTU: National Taiwan University)H-Index: 17
Last. Shih-Hung Yang (NTU: National Taiwan University)H-Index: 15
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INTRODUCTION: Pediatric spinal tumors are unique pathologies treated by pediatric neurosurgeons. Special attention is required for the preservation of neural function and bony alignment. We reported our experience in the management of these challenging lesions. METHODS: A total of 75 pediatric patients with spinal tumors treated at the National Taiwan University Hospital from 1998 to 2018 were identified retrospectively. Clinical data, radiographic image, and pathological report were reviewed fo...
#1Cheng-Tien Wu (PRC: China Medical University (PRC))H-Index: 14
#2Ting-Hua Yang (NTU: National Taiwan University)H-Index: 10
Last. Chang-Mu Chen (NTU: National Taiwan University)H-Index: 11
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The incidence of stroke recurrence is still higher despite the advanced progression of therapeutic treatment and medical technology. Low intensity pulsed ultrasound (LIPUS) has been demonstrated to possess therapeutic effects on neuronal diseases and stroke via brain-derived neurotrophic factor (BDNF) induction. In this study, we hypothesized that LIPUS treatment possessed therapeutic benefits for the improvement of stroke recurrence. Adult male C57BL/6J mice were subjected to a middle cerebral ...
3 CitationsSource
#1Hsin‐An A. Chen (TMU: Taipei Medical University)H-Index: 1
#2Chang Mu Chen (NTU: National Taiwan University)H-Index: 1
Last. Shing-Hwa Liu (NTU: National Taiwan University)H-Index: 44
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Abstract Background The pathology change of renal tubulointerstitial fibrosis is a critical feature of chronic kidney disease (CKD), regardless of the primary insults. The infiltration of inflammatory cells and the consecutive secretion of profibrotic factors are frequently and conspicuously observed during the development of renal fibrosis. Icariin, an active polyphenol of the Epimedium genus, has been found to alleviate the symptoms of chronic diseases like diabetes, neurodegeneration, and hea...
18 CitationsSource
#1Chang-Mu ChenH-Index: 11
#2Chien-Hao WuH-Index: 1
Last. Yi-Ho YoungH-Index: 18
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#1Chien-Hao Wu (Memorial Hospital of South Bend)H-Index: 1
#2Chang-Mu Chen (NTU: National Taiwan University)H-Index: 11
Last. Yi-Ho Young (NTU: National Taiwan University)H-Index: 18
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Abstract Objective This study reviewed our experience in treating patients with vestibular schwannoma (VS) who had acute sensorineural hearing loss (ASHL) early after radiosurgery. Patients and methods Seventy VS patients underwent cyberknife radiosurgery. Of them, 6 patients had ASHL early ( Results The mean hearing level of Group A was 39 ± 16 dB before radiosurgery, which deteriorated to 67 ± 14 dB at the onset of ASHL after radiosurgery. Three months after treatment for ASHL, hearing improve...
2 CitationsSource
#1Chang-Mu Chen (NTU: National Taiwan University)H-Index: 11
#2Cheng-Tien Wu (NTU: National Taiwan University)H-Index: 14
Last. Feng-Yi Yang (NYMU: National Yang-Ming University)H-Index: 20
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Stroke is known as the top 10 causes of death worldwide. Development of effectively neuroprotective or preventive strategies for ischemia stroke is imperative. For the purpose of stroke prevention, we tested the neuroprotective effects of low-intensity pulsed ultrasound (LIPUS) on ischemic stroke. Adult C57BL/6 mice were used to daily treatment with LIPUS for 5 days on left hemisphere before middle cerebral artery occlusion (MCAO)-induced cerebral ischemia/reperfusion injury. Western blotting an...
26 CitationsSource
#1Chang-Mu Chen (NTU: National Taiwan University)H-Index: 11
#2Cheng-Tien Wu (NTU: National Taiwan University)H-Index: 14
Last. Shing-Hwa Liu (NTU: National Taiwan University)H-Index: 44
view all 6 authors...
Defective activation and proliferation in microglial cells has been suggested to be associated with the increase of cerebral ischemia/reperfusion injury. We investigated the protection and molecular mechanism of green tea catechin on hypoxia/reperfusion-induced microglial cell injury in vitro. Microglial cells were cultured in hypoxia condition (O2 < 1%) and then re-incubated to the complete normal culture medium (reperfusion). Hypoxia/reperfusion obviously decreased cell viability and induced a...
23 CitationsSource
#1Chun-Wei Wang (NTU: National Taiwan University)H-Index: 12
#2Yin-Chun Lin (NTU: National Taiwan University)H-Index: 1
Last. Sung-Hsin Kuo (NTU: National Taiwan University)H-Index: 23
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Introduction The accuracy of radiation delivery is increasingly important as radiotherapy technology continues to develop. The goal of this study was to evaluate intrafractional motion during intracranial radiosurgery and the relationship between motion change and treatment time.
9 CitationsSource