Marco Del Chiaro
Anschutz Medical Campus
CancerInternal medicineRadiologySurgeryPathologyOncologySerous fluidRetrospective cohort studyDysplasiaIntraductal papillary mucinous neoplasmCarcinomaPancreatectomyPancreasPancreaticoduodenectomyMEDLINEPancreatic ductPancreatic cancerAdenocarcinomaIn patientGeneral surgeryMedicineGastroenterology
Publications 240
#1Marcus Holmberg (Karolinska University Hospital)
#2Poya Ghorbani (Karolinska University Hospital)H-Index: 2
Last. Ernesto Sparrelid (Karolinska University Hospital)H-Index: 11
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BACKGROUND/OBJECTIVES Resections for intraductal papillary mucinous neoplasm (IPMN) have increased last decades. Overall survival (OS) for conventional pancreatic ductal adenocarcinoma (PDAC) is well known but OS for invasive IPMN (inv-IPMN) is not as conclusive. This study aims to elucidate potential differences in clinicopathology and OS between these tumor types and to investigate if the raised number of resections have affected outcome. METHODS Consecutive patients ≥18 years of age resected ...
#1Caroline S. Verbeke (Oslo University Hospital)H-Index: 39
Last. Sanjay Kakar (UCSF: University of California, San Francisco)H-Index: 53
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Background and objectives null Current guidelines for the pathology reporting on pancreatic cancer differ in certain aspects, resulting in divergent reporting practice and a lack of comparability of data. Here we report on a new international dataset for the pathology reporting of resection specimens with cancer of the exocrine pancreas (ductal adenocarcinoma and acinar cell carcinoma). The dataset was produced under the auspices of the International Collaboration on Cancer Reporting (ICCR), a g...
#1Nikolaos MachairasH-Index: 2
#2Dimitri A. RaptisH-Index: 32
Last. Charles J. YeoH-Index: 155
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OBJECTIVE The aim of this study was to evaluate whether neoadjuvant therapy (NAT) critically influenced microscopically complete resection (R0) rates and long-term outcomes for patients with pancreatic ductal adenocarcinoma who underwent pancreatoduodenectomy (PD) with portomesenteric vein resection (PVR) from a diverse, world-wide group of high-volume centers. SUMMARY BACKGROUND DATA Limited size studies suggest that NAT improves R0 rates and overall survival compared to upfront surgery in rese...
#1Marco Del Chiaro (Anschutz Medical Campus)H-Index: 31
#2Robert J. Torphy (Anschutz Medical Campus)H-Index: 10
Last. Richard D. Schulick (Anschutz Medical Campus)H-Index: 104
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The incidence of pancreatic incidentalomas (PI) detected in otherwise asymptomatic patients is growing with the increasing quality and use of advanced imaging techniques. PI can present as isolated main pancreatic duct dilation or as a solid or cystic lesion. While historically thought to be relatively rare, PI are rather common, particularly cystic lesions of the pancreas, which can be detected in up to 49% of the general population. With the poor prognosis of pancreatic cancer, PI are an oppor...
#1S.J. Zakem (University of Colorado Denver)H-Index: 4
#2Adam C. Mueller (University of Colorado Denver)H-Index: 11
Last. Karyn A. Goodman (University of Colorado Denver)H-Index: 57
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Abstract Background The role of neoadjuvant stereotactic body radiation therapy (SBRT) in patients with borderline resectable pancreas cancer (BRPC) and locally advanced pancreas cancer (LAPC) remains controversial. Methods We retrospectively evaluated BRPC and LAPC patients treated at our institution who underwent 2–3 months of chemotherapy followed by SBRT to a dose of 30–33 Gy. Overall survival (OS) and recurrence-free survival (RFS) were estimated and compared by Kaplan–Meier and log-rank me...
1 CitationsSource
#1Pascal Probst (Heidelberg University)H-Index: 22
#2Felix J Hüttner (Heidelberg University)H-Index: 16
Last. Marco Del Chiaro (Anschutz Medical Campus)H-Index: 31
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BACKGROUND Pancreatic surgery is associated with considerable morbidity and, consequently, offers a large and complex field for research. To prioritize relevant future scientific projects, it is of utmost importance to identify existing evidence and uncover research gaps. Thus, the aim of this project was to create a systematic and living Evidence Map of Pancreatic Surgery. METHODS PubMed, the Cochrane Central Register of Controlled Trials, and Web of Science were systematically searched for all...
1 CitationsSource
#1Y. H. Andrew Wu (Anschutz Medical Campus)H-Index: 1
Last. Marco Del ChiaroH-Index: 31
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Intraductal papillary mucinous neoplasms (IPMN) are common but difficult to manage since accurate tools for diagnosing malignancy are unavailable. This study tests the diagnostic value of the main pancreatic duct (MPD) diameter for detecting IPMN malignancy using a meta-analysis of published data of resected IPMNs. Collected from a comprehensive literature search, the articles included in this analysis must report malignancy cases (high-grade dysplasia (HGD) and invasive carcinoma (IC)) and MPD ...
1 CitationsSource
#1Stefano CrippaH-Index: 60
Last. Marco Del Chiaro (Anschutz Medical Campus)H-Index: 31
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Abstract Background 2017 International and 2018 European guidelines are the most recent guidelines for intraductal papillary mucinous neoplasms management. Aim to evaluate the diagnostic accuracy of these guidelines in identifying malignant IPMN. Methods data from resected patients with IPMN were collected in two referral centers. Features of risk associated to cancerous degeneration described in International and European guidelines were retrospectively applied. Sensitivity, specificity, positi...
#1Hyeong Seok Kim (New Generation University College)H-Index: 4
#2Wookyeong Song (UPR-RP: UPRRP College of Natural Sciences)
Last. Jin-Young Jang (New Generation University College)H-Index: 54
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BACKGROUND Although we previously proposed a nomogram to predict malignancy in intraductal papillary mucinous neoplasms (IPMN) and validated it in an external cohort, its application is challenging without data on tumor markers. Moreover, existing nomograms have not been compared. This study aimed to develop a nomogram based on radiologic findings and to compare its performance with previously proposed American and Korean/Japanese nomograms. METHODS We recruited 3708 patients who underwent surgi...