Vikram Deshpande
University of Cambridge
Ultimate tensile strengthCancerFinite element methodPathologyDislocationComposite materialBeam (structure)Materials scienceDiseaseIgG4-related diseaseDeformation (mechanics)Cancer researchCarbon nanotubeMechanicsStructural engineeringMedicinePlasticitySandwich-structured compositeBiologyGastroenterology
816Publications
100H-index
34.7kCitations
Publications 826
Newest
#1Lipika Goyal (Harvard University)H-Index: 27
#2Christopher T. Chen (Harvard University)H-Index: 2
Last. Vikram Deshpande (Harvard University)H-Index: 100
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A Woman with Cholangiocarcinoma A 34-year-old woman was evaluated in the oncology clinic for the management of recurrent, metastatic intrahepatic cholangiocarcinoma. Before evaluation, an extended ...
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#1Siamak Soleymani Shishvan (University of Cambridge)H-Index: 10
#2Norman A. Fleck (University of Cambridge)H-Index: 89
Last. Vikram Deshpande (University of Cambridge)H-Index: 100
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Abstract We analyse the initiation of void growth in the Li electrode during the stripping phase of an Li-ion cell with a solid (ceramic) electrolyte. We first show that standard Butler-Volmer kinetics fails to predict the observed void formation. This motivated us to recognise that void initiation/growth involves power-law creep of the Li electrode that is linked to the motion of dislocations. We show, via thermodynamic considerations, that dislocations significantly affect the interface kineti...
1 CitationsSource
#1Elia Aguado-Fraile (Agios Pharmaceuticals)H-Index: 2
#2Ania Tassinari (Agios Pharmaceuticals)
Last. Vikram Deshpande (Harvard University)H-Index: 100
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Background:IDH1 mutations occur in approximately 13% of intrahepatic cholangiocarcinomas (IHCCs). The oral, targeted, mutant IDH1 (mIDH1) inhibitor ivosidenib (AG-120) suppresses production of the oncometabolite D-2-hydroxyglutarate, promoting disease stabilization and improved progression-free survival (PFS) in mIDH1 IHCC. Materials & methods: Harnessing matched baseline and on-treatment biopsies, we investigate the potential mechanisms underlying ivosidenib's efficacy. Results: mIDH1 inhibitio...
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#1Eric M. Przybyszewski (Harvard University)
#1Eric M. Przybyszewski (Harvard University)H-Index: 3
Last. Amiko M Uchida (Harvard University)
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#1Ashwin N. Ananthakrishnan (Harvard University)H-Index: 58
#2Vikram Deshpande (Harvard University)H-Index: 100
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#1Vikram Deshpande (University of Cambridge)H-Index: 100
#2Antonio DeSimoneH-Index: 39
Last. Pierre Recho (UGA: University of Grenoble)H-Index: 12
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While it is commonly observed that the shape dynamics of mammalian cells can undergo large random fluctuations, theoretical models aiming at capturing cell mechanics often focus on the deterministic part of the motion. In this paper, we present a framework that couples an active gel model of the cell mechanical scaffold with the complex cell metabolic system stochastically delivering the chemical energy needed to sustain an active stress in the scaffold. Our closure assumption setting the magnit...
#1P SeilerH-Index: 6
#2Kan LiH-Index: 11
Last. Norman A. FleckH-Index: 89
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1 CitationsSource
#1Kan Li (University of Cambridge)H-Index: 11
#2P Seiler (University of Cambridge)H-Index: 6
Last. Norman A. Fleck (University of Cambridge)H-Index: 89
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Abstract We propose a local reinforcement technique for lattices in the vicinity of a stress-raiser such as a notch, in order to elevate the macroscopic strength and ductility. A spatially non-uniform waviness distribution of sinusoidally-shaped struts is assumed in the vicinity of the notch, and the sensitivity of macroscopic tensile response to strut waviness distribution is studied by finite element analysis. Optimized lattice structures are determined in order to maximise the macroscopic ten...
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