Yusuke Mimura
BlackRock
Binding siteCrystal structureFragment crystallizable regionInternal medicineSurgeryAntigenMolecular biologyAntibodyReceptorChemistryImmunologyGlycanLung cancerSurvival rateExacerbationGlycosylationOligosaccharideIdiopathic pulmonary fibrosisHemoperfusionFc fragmentAnesthesiaCancer researchPlasma protein bindingBiochemistryMedicineCrystallographyBiologyGastroenterology
35Publications
14H-index
2,469Citations
Publications 34
Newest
#1Catherine M. Radcliffe (University of Oxford)H-Index: 23
#2James N. Arnold (University of Oxford)H-Index: 19
Last. Freda K. Stevenson (University of Southampton)H-Index: 80
view all 19 authors...
Expression of surface immunoglobulin appears critical for the growth and survival of B-cell lymphomas. In follicular lymphoma, we found previously that the Ig variable (V) regions in the B-cell receptor express a strikingly high incidence of N-glycosylation sequons, NX(S/T). These potential glycosylation sites are introduced by somatic mutation and are lymphoma-specific, pointing to their involvement in tumor pathogenesis. Analysis of the V region sugars from lymphoma-derived IgG/IgM reveals tha...
125 CitationsSource
#1Yusuke Mimura (University of Oxford)H-Index: 14
#2Denise Golgher (University of Southampton)H-Index: 7
Last. Tim Elliott (University of Southampton)H-Index: 55
view all 6 authors...
Class II molecules of the major histocompatibility complex (MHC class II molecules) bind peptides derived from protein antigens delivered into endocytic compartments and present these peptides to CD4+ T cells (Cresswell, 1994; Germain, 1994). In the endocytic pathway antigens are unfolded and cleaved into fragments during transport through the increasingly acidic endosomal network, from early endosomes to lysosomes. Newly synthesized MHC class II molecules associated with the invariant chains (I...
Source
#1Daniel A. Calarese (Scripps Research Institute)H-Index: 10
Last. Ian A. WilsonH-Index: 171
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Human antibody 2G12 neutralizes a broad range of human immunodeficiency virus type 1 (HIV-1) isolates by binding an unusually dense cluster of carbohydrate moieties on the “silent” face of the gp120 envelope glycoprotein. Crystal structures of Fab 2G12 and its complexes with the disaccharide Manα1-2Man and with the oligosaccharide Man9GlcNAc2 revealed that two Fabs assemble into an interlocked VH domain-swapped dimer. Further biochemical, biophysical, and mutagenesis data strongly support a Fab-...
895 CitationsSource
#1Stephan Krapp (MPG: Max Planck Society)H-Index: 9
#2Yusuke Mimura (University of Birmingham)H-Index: 14
Last. Peter Sondermann (MPG: Max Planck Society)H-Index: 2
view all 5 authors...
Antibodies may be viewed as adaptor molecules that provide a link between humoral and cellular defence mechanisms. Thus, when antigen-specific IgG antibodies form antigen/antibody immune complexes the effectively aggregated IgG can activate a wide range of effector systems. Multiple effector mechanisms result from cellular activation mediated through a family of IgG-Fc receptors differentially expressed on leucocytes. It is established that glycosylation of IgG-Fc is essential for recognition an...
827 CitationsSource
#1Stephan KrappH-Index: 9
#2Yusuke MimuraH-Index: 14
Last. Peter SondermannH-Index: 2
view all 5 authors...
Source
#1Stephan KrappH-Index: 9
#2Yusuke MimuraH-Index: 14
Last. Peter SondermannH-Index: 26
view all 5 authors...
Source
#1Stephan KrappH-Index: 9
#2Yusuke MimuraH-Index: 14
Last. Peter SondermannH-Index: 26
view all 5 authors...
Source
#1Stephan KrappH-Index: 9
#2Yusuke MimuraH-Index: 14
Last. Peter SondermannH-Index: 2
view all 5 authors...
Source
#1Yusuke Mimura (University of Birmingham)H-Index: 14
#1Y. Mimura (University of Birmingham)H-Index: 1
Last. Royston Jefferis (University of Birmingham)H-Index: 52
view all 6 authors...
Source
#1Yusuke Mimura (University of Birmingham)H-Index: 14
#1Y. Mimura (University of Birmingham)H-Index: 1
Last. Roy Jefferis (University of Birmingham)H-Index: 28
view all 7 authors...
Abstract Engagement of Fcγ receptors (FcγRs) with the Fc region of IgG elicits immune responses by leukocytes. The recent crystal structure of FcγRIII in complex with IgG-Fc has provided details of molecular interactions between these components (Sondermann, P., Huber, R., Oosthuizen, V., and Jacob, U. (2000) Nature406, 267–273). One of the most intriguing issues is that glycosylation of IgG-Fc is essential for the recognition by FcγRs although the carbohydrate moieties are on the periphery of t...
324 CitationsSource