Yiyue Zhang
South China University of Technology
HaematopoiesisUbiquitin ligaseMutantProgenitor cellImmunologyZebrafishLeukemiaMyeloid leukemiaMyeloidArabidopsisAbscisic acidStem cellMutationCancer researchGeneticsBotanyBiologyCell biologyMyelopoiesis
56Publications
19H-index
2,507Citations
Publications 61
Newest
#1Yan Zhao (SCUT: South China University of Technology)
#2Mei Wu (SCUT: South China University of Technology)H-Index: 2
Last. Yiyue Zhang (SCUT: South China University of Technology)H-Index: 19
view all 10 authors...
Hematopoietic stem cells (HSCs) possess the potential for self-renew and the capacity, throughout life, to differentiate into all blood cell lineages. Yet, the mechanistic basis for HSC development remains largely unknown. In this study, we characterized a zebrafish smu471 mutant with hematopoietic stem/progenitor cell (HSPC) defects and found that sart3 was the causative gene. RNA expression profiling of the sart3smu471 mutant revealed spliceosome and p53 signaling pathway to be the most signif...
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#1Mei Wu (SCUT: South China University of Technology)H-Index: 2
#2Yue Xu (SCUT: South China University of Technology)
Last. Jin Xu (SCUT: South China University of Technology)H-Index: 15
view all 11 authors...
Neutrophils are the most abundant vertebrate leukocytes and they are essential to host defense. Despite extensive investigation, the molecular network controlling neutrophil differentiation remains incompletely understood. GFI1 is associated with several myeloid disorders, but its role and the role of its co-regulators in granulopoiesis and pathogenesis are far from clear. Here, we demonstrate that zebrafish gfi1aa deficiency induces excessive neutrophil progenitor proliferation, accumulation of...
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#1Qing Lin (SCUT: South China University of Technology)
#2Riyang Zhou (SCUT: South China University of Technology)
Last. Yiyue Zhang (SCUT: South China University of Technology)H-Index: 19
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Platelets play an essential role in thrombosis and hemostasis. Abnormal hemostasis can cause spontaneous or severe post-traumatic bleeding. Bernard-Soulier syndrome (BSS) is a rare inherited bleeding disorder caused by a complete quantitative deficiency in the GPIb-IX-V complex. Multiple mutations in GP9 lead to the clinical manifestation of BSS. Understanding the roles and underlying mechanisms of GP9 in thrombopoiesis and establishing a proper animal model of BSS would be valuable to understan...
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#1Siting Lai (Southern Medical University)
#2Ankita Kumari (SCUT: South China University of Technology)H-Index: 2
Last. Jin Xu (SCUT: South China University of Technology)H-Index: 15
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The Metronidazole (MTZ)/nitroreductase (NTR)-mediated cell ablation system is the most commonly used chemical-genetic cell ablation method in zebrafish. This system can specifically ablate target cells under spatial and temporal control. The MTZ/NTR system has become a widely used cell ablation system in biological, developmental, and functional studies. However, the inadequate cell-ablation ability of some cell types and the side effects of high concentration MTZ impede extensive applications o...
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#1Shuo Gao (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Zixuan Wang (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Wenqing Zhang (SCUT: South China University of Technology)H-Index: 21
view all 12 authors...
The ubiquitin-proteasome system plays important roles in various biological processes as it degrades the majority of cellular proteins. Adequate proteasomal degradation of crucial transcription regulators ensures the proper development of neutrophils. The ubiquitin E3 ligase of Growth factor independent 1 (GFI1), a key transcription repressor governing terminal granulopoiesis, remains obscure. Here we report that the deficiency of the ring finger protein Interferon regulatory factor 2 binding pr...
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#1Jiakui Chen (Southern Medical University)H-Index: 2
#2Gaofei Li (SCUT: South China University of Technology)
Last. Yiyue Zhang (Southern Medical University)H-Index: 19
view all 9 authors...
Hematopoietic stem and progenitor cells (HSPCs) are able to self-renew and can give rise to all blood lineages throughout their lifetime, yet the mechanisms regulating HSPC development have yet to be discovered. In this study, we characterized a hematopoiesis defective zebrafish mutant line named smu07, which was obtained from our previous forward genetic screening, and found the HSPC expansion deficiency in the mutant. Positional cloning identified that slc20a1b, which encodes a sodium phosphat...
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#1Xiao Fang (SCUT: South China University of Technology)H-Index: 1
#2Song'en Xu (SCUT: South China University of Technology)H-Index: 1
Last. Wenqing Zhang (SCUT: South China University of Technology)H-Index: 21
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ASXL1 is one of the most frequently mutated genes in malignant myeloid diseases. In patients with myeloid malignancies, ASXL1 mutations are usually heterozygous frameshift or nonsense mutations leading to C-terminal truncation. Current disease models have predominantly total loss of ASXL1 or overexpressed C-terminal truncations. These models cannot fully recapitulate leukemogenesis and disease progression. We generated an endogenous C-terminal-truncated Asxl1 mutant in zebrafish that mimics huma...
1 CitationsSource
#1Ruimeng Yang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Ming Zhan (SJTU: Shanghai Jiao Tong University)
Last. Jun Zhu (SJTU: Shanghai Jiao Tong University)H-Index: 19
view all 11 authors...
Microglia are the primary immune cells in the central nervous system, which plays a vital role in neuron development and neurodegenerative diseases. Microglial precursors in peripheral hematopoietic tissues colonize the central nervous system during early embryogenesis. However, how intrinsic and extrinsic signals integrate to regulate microglia’s differentiation remains undefined. In this study, we identified the cerebral white matter hyperintensities susceptibility gene, programmed cell death ...
3 CitationsSource
#1Zhibin Huang (SCUT: South China University of Technology)H-Index: 7
#2Kemin Chen (SCUT: South China University of Technology)H-Index: 1
Last. Yiyue Zhang (SCUT: South China University of Technology)H-Index: 19
view all 8 authors...
Abstract Neutrophils play an essential role in the innate immune defense system in vertebrates. During hematopoiesis, the full function of neutrophils involves maturation of granules and related enzymes. Yet, transcription regulators that promote neutrophil maturation remain largely undefined. Here, two hematopoiesis-defective zebrafish mutants, runx1w84x and c-mybhkz3, were used to investigate the in vivo roles of Runx1 in cooperation with c-Myb in regulating neutrophil maturation. Loss of runx...
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#1Jing Li (Southern Medical University)
#2Panpan Meng (Southern Medical University)
Last. Qing Lin (SCUT: South China University of Technology)
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Abstract Famciclovir (FCV) is an antiviral drug that is often utilized after bone marrow transplantation to prevent viral infection. Yet, its role in hematopoiesis is poorly understood. Here, by utilizing a zebrafish model, we found that FCV exposure led to hematopoietic failure by impairing the proliferation of hematopoietic stem and progenitor cell (HSPC) and inducing HSPC apoptosis. On the other hand, FCV treatment could effectively relieve myeloid malignancies in the c-mybhyper MDS-like fish...
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