Indal Park
Kosin University
Drug resistanceInterleukin 6SurgeryProinflammatory cytokineMinimum inhibitory concentrationTumor necrosis factor alphaChemistrySplenocyteImmunologyUreaplasma urealyticumMycobacterium smegmatisCiprofloxacinMoxifloxacinMethylene blueTetracyclineLevofloxacinPhotodynamic therapyGene mutationAntibioticsMedicineBiologyMicrobiologyAntibiotic resistancePharmacology
Publications 15
#1Jung Youb Kang (Kosin University)
#2Woonhyoung Lee (Kosin University)H-Index: 12
Last. Sang Joon Lee (Kosin University)H-Index: 11
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Staphylococcus epidermidis is the most common pathogen in postoperative endophthalmitis and causes various infectious eye diseases. However, there is very little information on fluoroquinolone antibiotic resistance to S. epidermidis identified in conjunctival microbe and analysis of related genes. Here, the authors investigated the rate of resistance to fluoroquinolones of Staphylococcus epidermidis isolated from normal conjunctival microbes and mutations in the quinolone-resistance determining ...
#1Jiyeun Kate Kim (Kosin University)H-Index: 2
#2Ki Yup Nam (CNU: Chungnam National University)H-Index: 10
Last. Sang Joon Lee (Kosin University)H-Index: 11
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Postoperative endophthalmitis (PE) is the devastating complication that frequently results in vision loss. Recently, enterococcus have emerged as a major cause of PE in several countries and result...
1 CitationsSource
#1Insoo Shim (Kosin University)H-Index: 1
#2Myungwon Choi (Kosin University)H-Index: 3
Last. Indal Park (Kosin University)H-Index: 3
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Tuberculosis (TB) patients are normally treated with a combination of antibiotics. However, with improper or incomplete treatment of antibiotics, the disease may progress to multidrug-resistant TB (MDR-TB). The treatment of MDR-TB is very costly and inefficient. Therefore, there is a great demand of new therapeutic approaches for MDR-TB such as photodynamic therapy. In this study, we tried to optimize the conditions for photodynamic inactivation of TB using methylene blue as a photosensitizer. D...
3 CitationsSource
Abstract Purpose: The aim of this study was to investigate the factors that affect the precipitation of vancomycin and ceftazidime which are currently used in intravitreal injections for infectious endophthalmitis. Methods: The minimum concentration required for precipitation of the 2 antibiotics was estimated by 2-fold dilution. In addition, the amount of the precipitate that formed was measured at 4, 3, 2, and 1 mL volumes, temperatures (37°C or 4°C), and in different medias (balanced salt sol...
5 CitationsSource
#1Myungwon Choi (Kosin University)H-Index: 3
#2Indal Park (Kosin University)H-Index: 3
Recently, polymerase chain reaction (PCR)-based methods have been used to reclassify Ureaplasma urealyticum into two independent species (spp.), designating U. parvum and U. urealyticum. In the current study, we aim to reclassify U. urealyticum and to analyze the correlation between the presence of a genetic marker and an antibiotic resistance of U. urealyticum. Susceptibility test against tetracycline, levofloxain or moxifloxacin was performed by broth microdilution method. The presence of tet(...
2 CitationsSource
#1Myungwon Choi (Kosin University)H-Index: 3
#2Indal Park (Kosin University)H-Index: 3
Last. Kwang Hyuk Kim (Kosin University)H-Index: 1
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: In this study, we investigated the effects of β-lapachone (β-lap) on the production of cytokines in C57BL/6 mice. The culture supernatants of splenocytes exposed to β-lap plus lipopolysaccharide or concanavalin A (Con A) were harvested to determine Th1 (tumor necrosis factor-α, interferon-γ, interleukin [IL]-1β, IL-2, IL-17A, and IL-12) and Th2 (IL-4, IL-5, IL-6, and IL-10) cytokines. IL-2, a Th1 cytokine, was expressed at higher levels in splenocytes treated with β-lap and with lipopolysaccha...
1 CitationsSource
#1Myungwon ChoiH-Index: 3
#2Indal ParkH-Index: 3
Last. Park,Kun-YoungH-Index: 2
view all 3 authors...
#1Indal Park (Kosin University)H-Index: 3
#2Myungwon ChoiH-Index: 3
g/ml) in GyrB. These substitutions seem to have an impact on resistance to MF, and GyrB change was found only in the highest concentration and seems to be associated with high-level resistance to MF. This, as far as we know, is the first description of a relationship between MF resistance phenotype and genotype.Keywords : Mycoplasma hominis, moxifloxacin, resistance, QRDRs, mutations