Christine Fennema-Notestine
University of California, San Diego
PsychiatryInternal medicineMagnetic resonance imagingBrain morphometryPsychologyHeritabilityTwin studyNeuroscienceCognitionNeurocognitiveAlzheimer's Disease Neuroimaging InitiativeCerebral cortexAtrophyWhite matterAlzheimer's diseaseBrain mappingAudiologyNeuroimagingMedicineBiology
175Publications
56H-index
12.9kCitations
Publications 168
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#1Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
#2Olivia K. Puckett (UCSD: University of California, San Diego)H-Index: 1
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 30 authors...
INTRODUCTION The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep-wake cycle, modulating cognitive function, and AD progression. METHODS Participants were 481 men (ages 62 to 71.7) from the Vietnam Era Twin Study of Aging. LC structural integrity was indexed by neuromelanin-sensitive magnetic resonance imaging (MRI) contrast-to-noise ratio (LCCNR ). We examined LCCNR , cognition, amnestic mild cognitive imp...
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#1Hillary L Ditmars (BU: Boston University)H-Index: 1
#2Mark W. Logue (BU: Boston University)H-Index: 33
Last. Michael J. Lyons (BU: Boston University)H-Index: 85
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Background Clarifying the relationship between depression symptoms and cardiometabolic and related health could clarify risk factors and treatment targets. The objective of this study was to assess whether depression symptoms in midlife are associated with the subsequent onset of cardiometabolic health problems. Methods The study sample comprised 787 male twin veterans with polygenic risk score data who participated in the Harvard Twin Study of Substance Abuse ('baseline') and the longitudinal V...
1 CitationsSource
#1Graham M.L. Eglit (UCSD: University of California, San Diego)H-Index: 7
#2Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
Last. William S. KremenH-Index: 70
view all 26 authors...
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#1McKenna E. Williams (UCSD: University of California, San Diego)
#1McKenna E. Williams (UCSD: University of California, San Diego)H-Index: 1
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 13 authors...
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#1Christine Fennema-Notestine (UCSD: University of California, San Diego)H-Index: 56
#2Tricia A. Thornton-Wells (Vandy: Vanderbilt University)H-Index: 22
Last. Asha R. Kallianpur (Cleveland Clinic Lerner College of Medicine)H-Index: 24
view all 11 authors...
The pathogenesis of HIV-associated neurocognitive impairment (NCI) may involve iron dysregulation. In 243 HIV-seropositive adults without severe comorbidities, we therefore genotyped 250 variants in 20 iron-related genes and evaluated their associations with magnetic resonance imaging measures of brain structure and metabolites, including measures previously linked to NCI. Multivariable regression analyses examined associations between genetic variants and neuroimaging measures, adjusting for re...
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#1Carol E. Franz (UCSD: University of California, San Diego)H-Index: 48
#2Sean N. Hatton (UCSD: University of California, San Diego)H-Index: 22
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 20 authors...
Posttraumatic stress disorder (PTSD) is known to persist, eliciting early medical co-morbidity, and accelerated aging. Although PTSD diagnosis has been found to be associated with smaller volume in multiple brain regions, posttraumatic stress (PTS) symptoms and their associations with brain morphometry are rarely assessed over long periods of time. We predicted that persistent PTS symptoms across ~24 years would be inversely associated with hippocampal, amygdala, anterior cingulate volumes, and ...
6 CitationsSource
#1Nicola J. Armstrong (Murdoch University)H-Index: 41
#2Karen A. Mather (UNSW: University of New South Wales)H-Index: 39
Last. Paul A. Nyquist (NIH: National Institutes of Health)H-Index: 24
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Background and Purpose: Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause. In the first st...
11 CitationsSource
#1Laura M Campbell (UCSD: University of California, San Diego)H-Index: 7
#2Christine Fennema-Notestine (UCSD: University of California, San Diego)H-Index: 56
Last. Robert K. HeatonH-Index: 119
view all 18 authors...
Objective: Frascati international research criteria for HIV-associated neurocognitive disorders (HAND) are controversial; some investigators have argued that Frascati criteria are too liberal, resulting in a high false positive rate. Meyer et al. recommended more conservative revisions to HAND criteria, including exploring other commonly used methodologies for neurocognitive impairment (NCI) in HIV including the global deficit score (GDS). This study compares NCI classifications by Frascati, Mey...
3 CitationsSource
#1Alessandro LivelliH-Index: 1
#1A Livelli (UNITO: University of Turin)H-Index: 5
Last. Mengesha TeshomeH-Index: 5
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Summary Background Few large projects have evaluated the factors that influence the HIV RNA concentrations (viral load) in cerebrospinal fluid (CSF) during antiretroviral therapy (ART) over time. We aimed to determine the correlates of HIV RNA in CSF in a large cohort. Methods We analysed longitudinal data from adults living with HIV in the US CHARTER cohort. Participants in the CHARTER study were recruited from six US academic medical centres—in Baltimore (MD), Galveston (TX), New York (NY), St...
9 CitationsSource