Taehoon Chun
Korea University
GeneMessenger RNAInternal medicineEndocrinologyAntigenGene expressionMolecular biologyAntibodyChemistryComplementary DNAApoptosisImmunologyAutophagyT cellOpen reading frameCancer researchGeneticsBiochemistryCell growthMedicineCell cultureBiologyImmune systemCell biology
84Publications
22H-index
8,813Citations
Publications 86
Newest
#1Seok Jin Kang (KU: Korea University)H-Index: 3
#2In-Byung Park (KU: Korea University)
Last. Taehoon Chun (KU: Korea University)H-Index: 22
view all 0 authors...
Abstract null null A previous study has indicated that mRNA transcript of Rnf128 (Grail) is significantly increased in porcine epithelial cells expressing porcine circovirus type 2 (PCV2) open reading frame 5 (ORF5). RNF128 is an E3 ubiquitin ligase that can modulate the activity of target protein via ubiquitination of specific lysine residues. However, the function of RNF128 in PCV2-infected epithelial cells has not been well studied yet. Thus, the objective of the present study was to examine ...
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#1Min Kyeung Choi (Konkuk University)H-Index: 1
#2Minh Thong Le (Konkuk University)H-Index: 4
Last. Chankyu Park (Konkuk University)H-Index: 52
view all 11 authors...
Antimicrobial peptides (AMPs) are of interest as alternatives to antibiotics or immunomodulators. We generated and characterized the phenotypes of transgenic mice overexpressing protegrin 1 (PG1), a potent porcine cathelicidin. No obvious differences were observed between PG1 transgenic and wild-type mice in terms of growth, development, general behaviour, and the major immune cell population. However, PG1 transgenic mice intranasally infected with Staphylococcus aureus resulted in a reduction i...
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#1In Byung Park (KU: Korea University)H-Index: 1
#2Yong Chan Choi (KU: Korea University)H-Index: 1
Last. Taehoon Chun (KU: Korea University)H-Index: 22
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Porcine reproductive and respiratory syndrome virus (PRRSV) is a causative pathogen of PRRS, one of the most economically disastrous swine diseases. Non-structural protein 1 (NSP1) of PRRSV consists of NSP1α and NSP1β which exhibit papain like cysteine protease activity. Recent evidence demonstrates that PRRSV NSP1 may be participated in modulating host immunity, but very few host proteins were discovered as targets for NSP1. In this study, we used RNA-seq to investigate the functional role of P...
1 CitationsSource
#1In Byung Park (KU: Korea University)H-Index: 1
#2Taehoon Chun (KU: Korea University)H-Index: 22
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) is a causative pathogen of PRRS that has generated a serious adverse impact on current global pork production. PRRSV primarily infects pig alveolar macrophages, but poor induction of innate immunity after infection often leads to more severe complications. Defining the functional role of each PRRSV non structural protein (NSP) within host cells might be helpful in understanding how PRRSV induces poor innate immunity in host cel...
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#1Jeoung Eun LeeH-Index: 12
#2Ji Yoon LeeH-Index: 6
Last. Dong Ryul LeeH-Index: 21
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Summary Human pluripotent stem cells (PSCs) through somatic cell nuclear transfer (SCNT) may be an important source for regenerative medicine. The low derivation efficiency of stem cells and the accessibility of human oocytes are the main obstacles to their application. We previously reported that the efficiency of SCNT was increased by overexpression of H3K9me3 demethylase. Here, we applied a modified derivation method to the PSC line and first obtained human SCNT-PSC lines derived from both do...
2 CitationsSource
#1Seok Jin Kang (KU: Korea University)H-Index: 3
#2Taehoon Chun (KU: Korea University)H-Index: 22
Epigenetic regulation is mainly mediated by enzymes that can modify the structure of chromatin by altering the structure of DNA or histones. Proteins involved in epigenetic processes have been identified to study the detailed molecular mechanisms involved in the regulation of specific mRNA expression. Evolutionarily well-conserved polycomb group (PcG) proteins can function as transcriptional repressors by the trimethylation of histone H3 at the lysine 27 residue (H3K27me3) and the monoubiquitina...
5 CitationsSource
#1Joonbeom Bae (KU: Korea University)H-Index: 7
#2Sang Pil Choi (KU: Korea University)H-Index: 4
Last. Taehoon Chun (KU: Korea University)H-Index: 22
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The timely mobilization of hematopoietic stem and progenitor cells (HSPCs) is essential for maintaining hematopoietic and tissue leukocyte homeostasis. Understanding how HSPCs migrate between bone marrow (BM) and peripheral tissues is of great significance in the clinical setting, where therapeutic strategies for modulating their migration capacity determine the clinical outcome. Here, we identify an epigenetic regulator, Phc2, as a critical modulator of HSPC trafficking. The genetic ablation of...
5 CitationsSource
#1Chang Hee Lee (KU: Korea University)H-Index: 2
#2Taehoon Chun (KU: Korea University)H-Index: 22
: Macrophage is an important innate immune cell that not only initiates inflammatory responses, but also functions in tissue repair and anti-inflammatory responses. Regulating macrophage activity is thus critical to maintain immune homeostasis. Tyro3, Axl, and Mer are integral membrane proteins that constitute TAM family of receptor tyrosine kinases (RTKs). Growing evidence indicates that TAM family receptors play an important role in anti-inflammatory responses through modulating the function o...
10 CitationsSource
#1Hee Young Jeon (KU: Korea University)H-Index: 8
#2Seok Won Ham (KU: Korea University)H-Index: 7
Last. Hyunggee Kim (KU: Korea University)H-Index: 37
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Most glioblastomas frequently recur at sites of radiotherapy, but it is unclear if changes in the tumor microenvironment due to radiotherapy influence glioblastoma recurrence. Here, we demonstrate that radiation-induced senescent glioblastoma cells exhibit a senescence-associated secretory phenotype that functions through NFκB signaling to influence changes in the tumor microenvironment, such as recruitment of Ly6G+ inflammatory cells and vessel formation. In particular, Ly6G+ cells promote conv...
11 CitationsSource
#1Sang Pil Choi (KU: Korea University)H-Index: 4
#2Yong Chan Choi (KU: Korea University)H-Index: 1
Last. Taehoon Chun (KU: Korea University)H-Index: 22
view all 8 authors...
: The reproductive success of mammals is largely dependent on the interaction between maternal and foetal interfaces during early pregnancy. Particularly, immune cells which reside at the maternal endometrium can modulate the conception and placental vascularization. In this study, we analysed the transcription of genes involved in early pregnancy from endometrium and peripheral blood mononuclear cells (PBMCs) of pregnant pigs with different parity. Briefly, three groups of female pigs were divi...
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