Vincent Khoo
National Health Service
CancerInternal medicineRadiologyUrologySurgeryOncologyRandomized controlled trialMedical physicsProstateChemotherapyProstate cancerBladder cancerRectumProstate-specific antigenToxicityNuclear medicineConformal radiotherapyPlanning target volumeStereotactic body radiotherapyRadiation therapyMedicine
Publications 280
#1Emily Day (Imperial College London)H-Index: 2
#2A Toby Prevost ('KCL': King's College London)H-Index: 43
Last. Vincent Khoo (The Royal Marsden NHS Foundation Trust)H-Index: 62
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BACKGROUND Randomised controlled trials (RCTs) for surgical interventions have often proven difficult with calls for innovative approaches. The Imperial Prostate (IP4) Comparative Health Research Outcomes of Novel Surgery in prostate cancer (IP4-CHRONOS) study aims to deliver level 1 evidence on outcomes following focal therapy which involves treating just the tumour rather than whole-gland surgery or radiotherapy. Our aim is to test the feasibility of two parallel RCTs within an overarching str...
#1Robert Huddart (ICR: Institute of Cancer Research)H-Index: 83
#2Shaista Hafeez (ICR: Institute of Cancer Research)H-Index: 13
Last. Hybrid InvestigatorsH-Index: 1
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Purpose Hypofractionated radiation therapy can be used to treat patients with muscle-invasive bladder cancer unable to have radical therapy. Toxicity is a key concern, but adaptive plan-of the day (POD) image-guided radiation therapy delivery could improve outcomes by minimizing the volume of normal tissue irradiated. The HYBRID trial assessed the multicenter implementation, safety, and efficacy of this strategy. Methods HYBRID is a Phase II randomized trial that was conducted at 14 UK hospitals...
8 CitationsSource
#1Daryl Lim Joon (Monash University, Clayton campus)
Last. Vincent Khoo (National Health Service)H-Index: 62
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To assess visibility and artifact characteristics of polymer fiducials compared to standard gold fiducials for radiotherapy CT and MRI simulation. Three gold and three polymer fiducials were inserted into a CT and MRI tissue-equivalent phantom that approximated the prostate cancer radiotherapy configuration. The phantom and fiducials were imaged on CT and MRI. Images were assessed in terms of fiducial visibility and artifact. ImageJ was employed to quantify the pixel gray-scale of each fiducial ...
#1Martin J. ConnorH-Index: 10
#2Taimur T. Shah (Imperial College London)H-Index: 14
Last. Hashim U. AhmedH-Index: 62
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Introduction Survival in men diagnosed with de novo synchronous metastatic prostate cancer has increased following the use of upfront systemic treatment, using chemotherapy and other novel androgen receptor targeted agents, in addition to standard androgen deprivation therapy (ADT). Local cytoreductive and metastasis-directed interventions are hypothesised to confer additional survival benefit. In this setting, IP2-ATLANTA will explore progression-free survival (PFS) outcomes with the addition o...
1 CitationsSource
#1C. Chau (QA: Queen Alexandra Hospital)H-Index: 5
#1Caroline Chau (University Hospital Southampton NHS Foundation Trust)H-Index: 2
Last. Simon J. Crabb (University of Southampton)H-Index: 30
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BACKGROUND Small cell carcinoma of the bladder (SCCB) is rare, accounting for under 1% of all bladder carcinomas. It is aggressive and outcomes are poor due to early metastatic spread. Owing to its rarity, there are limitations on data to propose standardised management pathways. PATIENTS AND METHODS We conducted a retrospective analysis of patients presenting with pure or predominant histology SCCB to 26 UK institutions between 2006 and 2016. Data cut-off date was 1/2/2018. We report on patient...
1 CitationsSource
#1Martin J. Connor (Imperial College Healthcare)H-Index: 10
#2Vincent Khoo (The Royal Marsden NHS Foundation Trust)H-Index: 62
Last. Hashim U. Ahmed (Imperial College London)H-Index: 62
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#1Simon J. Crabb (University of Southampton)H-Index: 30
#2Gareth Griffiths (University of Southampton)H-Index: 30
Last. Robert Jones (Beatson West of Scotland Cancer Centre)H-Index: 47
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PURPOSECapivasertib is a pan-AKT inhibitor. Preclinical data indicate activity in metastatic castration-resistant prostate cancer (mCRPC) and synergism with docetaxel.PATIENTS AND METHODSProCAID wa...
4 CitationsSource
#1Daryl Lim JoonH-Index: 17
#2Michael ChaoH-Index: 9
Last. Vincent Khoo (Monash University)H-Index: 62
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INTRODUCTION Guidelines recommend that the proximal seminal vesicles (PrSV) should be included in the clinical target volume for locally advanced prostate cancer patients undergoing radiotherapy. Verification and margins for the prostate may not necessarily account for PrSV displacement. The purpose was to determine the inter-fraction displacement of the PrSV relative to the prostate during radiotherapy. METHODS Fiducials were inserted into the prostate, and right and left PrSV (RSV and LSV) in ...
#1Daryl Lim Joon (Monash University)H-Index: 17
Last. Vincent Khoo (Monash University)H-Index: 62
view all 17 authors...
Abstract Background and purpose Image-guidance with fiducials has been shown to improve pelvic radiotherapy outcome. However, bladder fiducials using ethiodized oil (EO) alone can disperse widely, and gold causes Computed Tomography scan (CT) metal artifacts. The study's purpose was to investigate the ability to deliver EO-tissue glue fiducials and compare them to gold for bladder radiotherapy image guidance. Materials and methods A fluid-filled porcine bladder model was used to assess the abili...