Javier Sastre
Hospital Clínico San Carlos
CancerInternal medicineSurgeryOncologyImmunologyAsthmaChemotherapyBevacizumabCapecitabineIrinotecanFluorouracilOxaliplatinKRASRegimenPopulationIn patientColorectal cancerClinical trialMedicineGastroenterology
316Publications
56H-index
7,780Citations
Publications 316
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#1N. MigueresH-Index: 1
#2Olivier Vandenplas (UCL: Université catholique de Louvain)H-Index: 55
Last. F. de BlayH-Index: 26
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Resume Contexte Bien que l’evaluation de l’inflammation bronchique, par expectoration induite, permette d’identifier differents phenotypes, chez les patients asthmatiques, il n’y a que peu d’informations sur le determinant du pattern d’inflammation bronchique chez les patients presentant un asthme professionnel par sensibilisation. Objectif Determiner si le pattern d’inflammation bronchique, determine par expectoration induite, permet de definir des phenotypes cliniques distincts. Methode Cette ...
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#9Gema DuránH-Index: 3
#10Javier Sastre (Hospital Clínico San Carlos)H-Index: 56
Last. Enrique Aranda (ISCIII: Carlos III Health Institute)H-Index: 35
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BACKGROUND Biologicals, in combination with chemotherapy, are recommended as first-line treatment of metastatic colorectal cancer (mCRC); however, evidence guiding the appropriate management of older patients with mCRC is limited. OBJECTIVE This study was undertaken to compare the efficacy and safety outcomes in older versus younger patients with mCRC who received first-line biological therapy. METHODS This retrospective analysis used pooled data from five trials undertaken by the Spanish Cooper...
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#2Isam Alobid (University of Barcelona)H-Index: 39
Last. Javier SastreH-Index: 56
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Airway examination techniques are procedures that can potentially transmit infectious diseases to both patients and healthcare professionals who perform them, by various mechanisms. The pandemic situation due to the COVID-19 disease has practically halted most of the activity of the clinics and laboratories of pulmonary and nasal function, with clear recommendations in this regard. Being already in the early stages after the peak of the pandemic, we still do not know for sure what its consequenc...
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#1Marta BenaventH-Index: 10
#2Javier SastreH-Index: 56
Last. Javier GallegoH-Index: 17
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BACKGROUND AND OBJECTIVE Patient-reported outcome measures can provide clinicians with valuable information to improve doctor-patient communication and inform clinical decision-making. The aim of this study was to evaluate the physician-perceived utility of the QLQ-GINET21 in routine clinical practice in patients with gastrointestinal neuroendocrine tumours (GI-NETs). Secondary aims were to explore the patient, clinician, and/or centre-related variables potentially associated with perceived clin...
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#1Enrique Aranda (ISCIII: Carlos III Health Institute)H-Index: 35
#2Jose María VieitezH-Index: 13
Last. Eduardo Díaz-Rubio (Hospital Clínico San Carlos)H-Index: 67
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ABSTRACT Purpose 5-Fluorouracil/leucovorin, oxaliplatin, irinotecan (FOLFOXIRI) plus bevacizumab is more effective than doublets plus bevacizumab as first-line therapy for metastatic colorectal cancer, but is not widely used because of concerns about toxicity and lack of predictive biomarkers. This study was designed to explore the role of circulating tumour cell (CTC) count as a biomarker to select patients for therapy with FOLFOXIRI-bevacizumab. Patients and methods VISNU-1 was a multicentre, ...
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#1Javier Sastre (Hospital Clínico San Carlos)H-Index: 56
#2Virginia de la Orden (Hospital Clínico San Carlos)H-Index: 8
Last. Enrique Aranda (ISCIII: Carlos III Health Institute)H-Index: 35
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ABSTRACT This is a post-hoc analysis of biomarkers from a large cohort of chemo-naive metastatic colorectal cancer. Both high baseline circulating tumor cell count and RASmut (RAS mutated) were associated with clinical or pathologic features classically associated with poor prognosis. Selection of high- and low-risk populations may help to individualize approaches in the future. Background Clinicopathologic characteristics and prognostic and predictive factors offer valuable guidance when select...
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