Suraj P. Parihar
University of Cape Town
GeneInternal medicineEndocrinologyIntracellular parasiteMolecular biologyAntibodyProinflammatory cytokineRegulation of gene expressionPolyunsaturated fatty acidImmunologyVirusT cellBALB/cInflammationMycobacterium tuberculosisDendritic cellCutaneous leishmaniasisMacrophageLeishmania majorSpleenTuberculosisPhagosome maturationDNAMedicineBiologyImmune systemMicrobiologyCell biologyPharmacology
37Publications
14H-index
732Citations
Publications 32
Newest
#1Frank Ekow Atta Hayford (College of Health Sciences, Bahrain)H-Index: 3
#2Robin C Dolman (NWU: North-West University)H-Index: 6
Last. Suraj P. PariharH-Index: 14
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Some vulnerable population groups at risk for tuberculosis (TB) may have a low n-3 polyunsaturated fatty acid (PUFA) status. Our research previously showed that adjunct n-3 LCPUFA in TB are beneficial in n-3 PUFA sufficient C3HeB/FeJ mice. Here we investigated the effect of adjunct n-3 LCPUFA supplementation to TB-mice with a low, compared to a sufficient n-3 PUFA status. Mice were conditioned on an n-3 PUFA-deficient (n-3FAD) or n-3 PUFA-sufficient (n-3FAS) diet for six weeks prior to Mycobacte...
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#1Arista Nienaber (NWU: North-West University)H-Index: 2
#2Mumin Ozturk (International Centre for Genetic Engineering and Biotechnology)H-Index: 8
Last. Linda Malan (NWU: North-West University)H-Index: 8
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Intakes of the omega-3 essential fatty acids (n-3 EFAs) are low in the general adult population, with high n-6/n-3 polyunsaturated fatty acid (PUFA) ratios and the accompanying suboptimal n-3 PUFA status. Eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) have antibacterial and inflammation-resolving effects in tuberculosis (TB). However, whether switching to a diet with optimum n-3 EFA intake after the infection has comparable benefits has not been investigated. We aimed to compare the effec...
1 CitationsSource
#1Frank Ekow Atta Hayford (NWU: North-West University)H-Index: 3
#2Mumin Ozturk (International Centre for Genetic Engineering and Biotechnology)H-Index: 8
Last. Linda Malan (NWU: North-West University)H-Index: 8
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Advancement in the understanding of inflammation regulation during tuberculosis (TB) treatment has led to novel therapeutic approaches being proposed. The use of immune mediators like anti-inflammatory and pro-resolving molecules for such, merits attention. Drug repurposing is a widely used strategy that seeks to identify new targets to treat or manage diseases. The widely explored nonsteroidal anti-inflammatory drug (NSAID) ibuprofen and a more recently explored pharmaconutrition therapy using ...
1 CitationsSource
#1Arista Nienaber (NWU: North-West University)H-Index: 2
#2Mumin Ozturk (International Centre for Genetic Engineering and Biotechnology)H-Index: 8
Last. Linda Malan (NWU: North-West University)H-Index: 8
view all 13 authors...
Non-resolving inflammation is characteristic of tuberculosis (TB). Given their inflammation-resolving properties, omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) may support TB treatment. This research aimed to investigate the effects of n-3 LCPUFA on clinical and inflammatory outcomes of Mycobacterium tuberculosis (Mtb)-infected C3HeB/FeJ mice with either normal or low n-3 PUFA status before infection. Using a two-by-two design, uninfected mice were conditioned on either an n-3 PUFA...
1 CitationsSource
#1Uzma Saqib (IITI: Indian Institute of Technology Indore)H-Index: 8
#2Masood A. Khan (Qassim University)H-Index: 20
Last. Mirza S. Baig (IITI: Indian Institute of Technology Indore)H-Index: 10
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Atherosclerosis (AS) is a widespread pathological coronary heart disease (CHD), which, along with other cardiovascular diseases (CVDs), is the primary cause of global mortality. It is initiated by the accumulation of cholesterol-laden macrophages in the artery wall, thereby forming the foam-cells, the hallmark of AS. Increased influx of oxidized LDL and decreased efflux of free cholesterol from macrophages constitute major factors that mediate the progression of AS. Natural compounds treatment a...
1 CitationsSource
#4Julius Ebua Chia (International Centre for Genetic Engineering and Biotechnology)H-Index: 1
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#1Arista Nienaber (NWU: North-West University)H-Index: 2
#2Jeannine Baumgartner (NWU: North-West University)H-Index: 15
Last. Linda Malan (NWU: North-West University)H-Index: 8
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Progressive inflammation and anemia are common in tuberculosis (TB) and linked to poor clinical outcomes. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have inflammation-resolving properties, whereas iron supplementation in TB may have limited efficacy and enhance bacterial growth. We investigated effects of iron and EPA/DHA supplementation, alone and in combination, on inflammation, anemia, iron status markers and clinical outcomes in Mycobacterium tuberculosis-infected C3HeB/FeJ m...
4 CitationsSource
#1Sabelo Hadebe (South African Medical Research Council)H-Index: 3
#2Melissa Chengalroyen (UCT: University of Cape Town)
Last. Hlumani Ndlovu (UCT: University of Cape Town)H-Index: 8
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Tuberculosis (TB), caused by the highly infectious Mycobacterium tuberculosis , remains a leading cause of death worldwide, with an estimated 1.6 million associated deaths reported in 2017. In South Africa, an estimated 322,000 people were infected with TB in 2017, and a quarter of them lost their lives due to the disease. Bacille Calmette-Guerin (BCG) remains the only effective vaccine against disseminated TB, but its inability to confer complete protection against pulmonary TB in adolescents a...
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#9Santosh Kumar (International Centre for Genetic Engineering and Biotechnology)H-Index: 7
Basic leucine zipper transcription factor 2 (Batf2) activation is detrimental in Type 1-controlled infectious diseases, demonstrated during infection with Mycobacterium tuberculosis (Mtb) and Listeria monocytogenes Lm. In Batf2-deficient mice (Batf2−/−), infected with Mtb or Lm, mice survived and displayed reduced tissue pathology compared to infected control mice. Indeed, pulmonary inflammatory macrophage recruitment, pro-inflammatory cytokines and immune effectors were also decreased during tu...
7 CitationsSource
#1Suraj P. PariharH-Index: 14
#2Reto Guler (South African Medical Research Council)H-Index: 26
Last. Frank Brombacher (South African Medical Research Council)H-Index: 83
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Statins were first identified over 40 years ago as lipid-lowering drugs and have been remarkably effective in treating cardiovascular diseases. As research advanced, the protective effects of statins were additionally attributed to their anti-inflammatory, antioxidative, anti-thrombotic and immunomodulatory functions rather than lipid-lowering abilities alone. By promoting host defence mechanisms and inhibiting pathological inflammation, statins increase survival in human infectious diseases. At...
43 CitationsSource