Hui-Ying Chang
Rutgers University
SurgeryPathologyMolecular biologyGap junctionChemistryNitrogen mustardKeratin 17HairlessConnexinWound healingBifunctionalSulfur mustardAntisense therapySkin blistersSkin InjuryDynamic modulationSkin woundAntisense oligodeoxynucleotidesEpitheliumDNAMedicineCell adhesion
Publications 3
#1Yoke-Chen ChangH-Index: 7
#2Hui-Ying ChangH-Index: 2
Last. Donald R. GereckeH-Index: 19
view all 6 authors...
Sulfur mustard (SM) and its analog nitrogen mustard (NM) are potent bifunctional alkylating agents that induce skin blisters. They crosslink proteins and DNA and alter cell adhesion of basement membrane molecules. Dermal toxicity of the mustard agents includes separation of the epidermis and dermis, a strong inflammatory response, and prolonged wound healing. Matricellular proteins (MPs) including SPARC and hevin (aka SPARC-like 1) are secreted proteins that are incorporated into the provisional...
#1Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
#2Hui-Ying Chang (RU: Rutgers University)H-Index: 2
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 19
view all 7 authors...
Connexin 43 (Cx43) antisense treatment accelerates diabetic skin wound repair. Cx43 expression and its phosphorylation (pCx43) alters gap junction communication during skin wound repair. Vesicant induced skin injury results in prolonged wound healing similar to diabetic wounds. We performed a time course study using Cx43 antisense oligodeoxynucleotides (asODN) on nitrogen mustard (NM) injured SKH-1 hairless mouse dorsal skin to evaluate wound progression and Cx expression. Immunofluorescent (IF)...
#1Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
#2James D. Wang (RU: Rutgers University)H-Index: 2
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 19
view all 6 authors...
Gap junction communication is tightly regulated in skin wound healing. Studies showed that targeting of connexin43 (Cx43) improves skin wound repair in diabetes. Vesicant induced skin injury result...
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