Kenneth K.W. To
The Chinese University of Hong Kong
CytotoxicityDrug resistanceCancerMultiple drug resistanceMolecular biologyChemistryEffluxIn vivoCisplatinP-glycoproteinTyrosine-kinase inhibitorDoxorubicinATP-binding cassette transporterCancer researchAbcg2MedicineProtein kinase BBiologyCancer cellPharmacology
127Publications
32H-index
3,643Citations
Publications 122
Newest
#1Kenneth K.W. To (CUHK: The Chinese University of Hong Kong)H-Index: 32
#2William C. ChoH-Index: 37
INTRODUCTION Messenger RNA (mRNA)-based therapeutics and vaccines have emerged as a disruptive new drug class for various applications, including regenerative medicine, cancer treatment, and prophylactic and therapeutic vaccinations. AREAS COVERED This review provides an update about the rational structure-based design of various formats of mRNA-based therapeutics. The authors discuss the recent advances in the mRNA modifications that have been used to enhance stability, promote translation effi...
Source
#1Ziwei Li (CUHK: The Chinese University of Hong Kong)
#2Yuanfeng Lyu (CUHK: The Chinese University of Hong Kong)
Last. Zhong Zuo (CUHK: The Chinese University of Hong Kong)H-Index: 40
view all 8 authors...
Concurrent use of simvastatin (SV) and Gardenia jasminoides J. Ellis (GJ) was adopted in patients with multi-morbidity, such as stroke rehabilitation patients with NASH. Although hepatotoxicity has been reported in both of them and NASH could alter the pharmacokinetics of drugs/herbs, the interaction between SV and GJ and the related hepatotoxicity remained uninvestigated under neither healthy nor NASH condition. The current study aimed to evaluate the potential hepatotoxicity resulted from the ...
Source
#1Hong Zhang (SYSU: Sun Yat-sen University)H-Index: 5
#2Yuhui Xia (SYSU: Sun Yat-sen University)
Last. Liwu Fu (SYSU: Sun Yat-sen University)H-Index: 19
view all 14 authors...
Despite the great success of immunotherapy in a small subset of cancer patients, most colorectal cancer (CRC) patients do not respond to programmed cell death receptor 1 (PD-1) blockade immunotherapy. There is an urgent medical need to elucidate how cancer cells evade immune response and to develop novel means to boost the efficacy of immune checkpoint inhibitors. In this study, alcohol induces ligand programmed cell death receptor 1 (PD-L1) expression of CRC cells in vitro and in vivo. Alcohol ...
Source
#1Wei YanH-Index: 3
Last. Sharon Shui Yee LeungH-Index: 19
view all 4 authors...
Source
#1Wei Yan (CUHK: The Chinese University of Hong Kong)H-Index: 3
#2Parikshit Banerjee (CUHK: The Chinese University of Hong Kong)H-Index: 6
Last. Sharon Sy Leung (CUHK: The Chinese University of Hong Kong)H-Index: 1
view all 9 authors...
Abstract With the emergence of multidrug resistance (MDR) bacteria, wound infection continues to be a challenging problem and represents a considerable healthcare burden. This study aims to evaluate the applicability of a phage loaded thermosensitive hydrogel in managing wound infections caused by MDR Acinetobacter baumannii, using IME-AB2 phage and MDR-AB2 as the model phage and bacteria, respectively. Excellent storage stability of the IME-AB2 phage in a ∼18 wt% Poloxamer 407 (P407) hydrogel s...
Source
#1Kenneth K.W. To (CUHK: The Chinese University of Hong Kong)H-Index: 32
#2William C. ChoH-Index: 37
Drug resistance is the major reason accounting for the treatment failure in cancer chemotherapy. Dysregulation of the epigenetic machineries is known to induce chemoresistance. It was reported that numerous genes encoding the key mediators in cancer proliferation, apoptosis, DNA repair, and drug efflux are dysregulated in resistant cancer cells by aberrant DNA methylation. The imbalance of various enzymes catalyzing histone post-translational modifications is also known to alter chromatin config...
Source
#1Zi-wei Li (CUHK: The Chinese University of Hong Kong)H-Index: 7
#2Jun Zhang (CUHK: The Chinese University of Hong Kong)H-Index: 1
Last. Zhong Zuo (CUHK: The Chinese University of Hong Kong)H-Index: 40
view all 11 authors...
BACKGROUND AND PURPOSE Altered drug pharmacokinetics is a significant concern in non-alcoholic steatohepatitis (NASH) patients. Although high-fat high-cholesterol (HFHC) diet-induced NASH (HFHC-NASH) rats could simulate the typical dysregulation of cholesterol in NASH patients, experimental investigation on the altered drug pharmacokinetics in this model are limited. Thus, the present study comprehensive investigates the nature of such altered pharmacokinetics using simvastatin as the model drug...
Source
#1Shaocong Wu (SYSU: Sun Yat-sen University)H-Index: 2
#2Min Luo (SYSU: Sun Yat-sen University)H-Index: 5
Last. Liwu Fu (SYSU: Sun Yat-sen University)H-Index: 19
view all 10 authors...
BACKGROUND Epidermal growth factor receptor (EGFR)-mutated lung cancer constitutes a major subgroup of non-small cell lung cancer (NSCLC) and osimertinib is administrated as first-line treatment. However, most patients with osimertinib treatment eventually relapse within one year. The underlying mechanisms of osimertinib resistance remain largely unexplored. METHODS Exosomes isolation was performed by differential centrifugation. Co-culture assays were conducted to explore the alteration of drug...
1 CitationsSource
#1Xu Wu (CUHK: The Chinese University of Hong Kong)H-Index: 4
#1Xu Wu (CUHK: The Chinese University of Hong Kong)H-Index: 15
Last. Ge Lin (CUHK: The Chinese University of Hong Kong)H-Index: 55
view all 11 authors...
Abstract Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which...
Source
#1Winnie Fong (CUHK: The Chinese University of Hong Kong)H-Index: 3
#2Kenneth K.W. To (CUHK: The Chinese University of Hong Kong)H-Index: 32
BACKGROUND Drug repurposing is emerging as an attractive strategy with lower attrition rate, lower cost and shorter timeframe than traditional drug discovery methods. Chloroquine (CQ) and its analogs are old drugs originally indicated for malaria treatment. Serendipitous discovery in early years revealed its anti-inflammatory properties, thus allowing its repositioned use in autoimmune diseases. Recent evidence also suggested its potential therapeutic use for anticancer therapy. OBJECTIVE This a...
Source