Mark E. Ladd
German Cancer Research Center
Imaging phantomPhysicsRadiologyBiomedical engineeringMagnetic resonance imagingPsychologyTomographyNeuroscienceChemistryMaterials scienceRoentgenContrast (vision)CerebellumMr imagingNuclear medicineElectromagnetic coilComputer scienceNuclear magnetic resonanceImage qualityMedicine
Publications 365
#1Dominik LudwigH-Index: 1
#2Frederik Bernd LaunH-Index: 27
Last. Tristan Anselm Kuder (DKFZ: German Cancer Research Center)H-Index: 19
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Diffusion-weighted imaging (DWI) is a powerful non-invasive tool which is widely used in clinical routine. Mostly, apparent diffusion coefficient maps are acquired, which cannot be directly related to cellular structure. More recently it was shown that DWI is able to reconstruct pore shapes using a specialized magnetic field gradient scheme so that cell size distributions may be obtained. So far, artificial systems have been used for experimental demonstration without extraporal signal component...
#1Feng Jia (University of Freiburg)H-Index: 7
#2Sebastian Littin (University of Freiburg)H-Index: 6
Last. Maxim Zaitsev (Medical University of Vienna)H-Index: 38
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Abstract null null Diffusion-weighted imaging (DWI) in the female breast is a magnetic resonance imaging (MRI) technique that complements clinical routine protocols, and that might provide an independent diagnostic value for specific clinical tasks in breast imaging. To further improve specificity of DWI in the breast, stronger and faster diffusion weighting is advantageous. Here, a dedicated gradient coil is designed, targeted at diffusion weighting in the female breast, with the peak gradient ...
#1Tanja Platt (DKFZ: German Cancer Research Center)H-Index: 5
#2Mark E. LaddH-Index: 60
Last. Daniel PaechH-Index: 22
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ABSTRACT Ultrahigh magnetic fields offer significantly higher signal-to-noise ratio, and several magnetic resonance applications additionally benefit from a higher contrast-to-noise ratio, with static magnetic field strengths of B0 ≥ 7 T currently being referred to as ultrahigh fields (UHFs). The advantages of UHF can be used to resolve structures more precisely or to visualize physiological/pathophysiological effects that would be difficult or even impossible to detect at lower field strengths....
#1Julian Emmerich (DKFZ: German Cancer Research Center)H-Index: 5
#2P Bachert (Heidelberg University)H-Index: 13
Last. Sina Straub (DKFZ: German Cancer Research Center)H-Index: 7
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PURPOSE: A phantom is presented in this study that allows for an experimental evaluation of QSM reconstruction algorithms. The phantom contains susceptibility producing particles with dia- and paramagnetic properties embedded in an MRI visible medium and is suitable to assess the performance of algorithms that attempt to separate isotropic dia- and paramagnetic susceptibility at the sub-voxel level. METHODS: The phantom was built from calcium carbonate (diamagnetic) and tungsten carbide particle...
#1Simon Schmidt (DKFZ: German Cancer Research Center)
#2Martin Bruschewski (University of Rostock)H-Index: 5
Last. Sebastian Schmitter (German National Metrology Institute)H-Index: 24
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PURPOSE To develop a phase-contrast (PC) -based method for direct and unbiased quantification of the acceleration vector field by synchronization of the spatial and acceleration encoding time points. The proposed method explicitly aims at in-vitro applications, requiring high measurement accuracy, as well as the validation of clinically relevant acceleration-encoded sequences. METHODS A velocity-encoded sequence with synchronized encoding (SYNC SPI) was modified to allow direct acceleration mapp...
#2Peter Bachert (DKFZ: German Cancer Research Center)H-Index: 37
Abstract null null Purpose null In biological tissue, phase contrast is determined by multiple substances such as iron, myelin or calcifications. Often, these substances occur co-located within the same measurement volume. However, quantitative susceptibility mapping can solely measure the average susceptibility per voxel. To provide new insight in disease progression and mechanisms in neurological diseases, where multiple processes such as demyelination and iron accumulation occur simultaneousl...
#1Stephan Orzada (DKFZ: German Cancer Research Center)H-Index: 19
#2Thomas Fiedler (DKFZ: German Cancer Research Center)H-Index: 27
Last. Mark E. LaddH-Index: 60
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PURPOSE Compression of local specific absorption rate (SAR) matrices is essential for enabling SAR monitoring and efficient pulse calculation in parallel transmission. Improvements in compression result in lower error margin and/or lower number of virtual observation points (VOPs). The purpose of this work is to introduce two algorithms for post-processing of already compressed VOP sets. One calculates individual overestimation matrices for the VOPs to reduce overestimation, the other identifies...
#1Thomas Fiedler (DKFZ: German Cancer Research Center)H-Index: 27
#2Stephan Orzada (DKFZ: German Cancer Research Center)H-Index: 19
Last. Andreas K. Bitz (DKFZ: German Cancer Research Center)H-Index: 22
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The aim of the current study was to investigate the performance of integrated RF transmit arrays with high channel count consisting of meander microstrip antennas for body imaging at 7 T and to optimize the position and number of transmit elements. RF simulations using multiring antenna arrays placed behind the bore liner were performed for realistic exposure conditions for body imaging. Simulations were performed for arrays with as few as eight elements and for arrays with high channel counts o...
#1Till M. Schneider (Heidelberg University)H-Index: 4
#2Jackie Ma (Heinrich Hertz Institute)H-Index: 6
Last. Sina Straub (DKFZ: German Cancer Research Center)H-Index: 7
view all 9 authors...
Objectives: To characterize subcortical nuclei by multiparametric quantitative magnetic resonance imaging. Materials and Methods: The following quantitative multiparametric MR data of five healthy volunteers were acquired on a 7T MRI system: (1) 3D gradient echo (GRE) data for the calculation of quantitative susceptibility maps (QSM), (2) GRE sequences with and without off-resonant magnetic transfer pulse for magnetization transfer ratio (MTR) calculation, (3) a magnetization‐prepared 2 rapid ac...
#1Fabian J. Kratzer (DKFZ: German Cancer Research Center)H-Index: 1
#2Sebastian Flassbeck (DKFZ: German Cancer Research Center)H-Index: 4
Last. Armin M. Nagel (DKFZ: German Cancer Research Center)H-Index: 32
view all 10 authors...
PURPOSE To develop a framework for 3D sodium (23 Na) MR fingerprinting (MRF), based on irreducible spherical tensor operators with tailored flip angle (FA) pattern and time-efficient data acquisition for simultaneous quantification of T1 , T2l∗ , T2s∗ , and T2∗ in addition to ΔB0 . METHODS 23 Na-MRF was implemented in a 3D sequence and irreducible spherical tensor operators were exploited in the simulations. Furthermore, the Cramer Rao lower bound was used to optimize the flip angle pattern. A c...
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